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Basic and Translational Research

Our basic research activities seek to improve patient outcomes by studying the mechanisms involved in several diseases and by developing new therapeutics.

Our mechanistic research includes efforts to understand:

  • Barriers in solid organ transplantation
  • Fundamental mechanisms of apoptosis
  • Events in several major cancer signaling pathways
  • Cellular immune biomarkers predictive of human disease outcomes
  • Host-pathogen interactions in HIV 

Novel therapeutics under development include:

  • Tumor-targeting reagents
  • Novel vaccines to fight cancer and viral infections 

Research Programs

Cancer Genetics and Biology

Labs

Several laboratories in the division investigate questions in cancer genetics and cancer biology.

Applied Therapeutics
Identifying, quantifying and eliminating local disease while preserving and optimizing functional recovery

Devi Research Lab
Studying basic and fundamental mechanisms of apoptosis, or programmed cell death

Endocrine Neoplasia Laboratory
Investigating how tumor-specific dysregulation of the pRB signaling pathway affects downstream gene expression and the cellular response to DNA damage

Nair Research Lab
Designing and testing novel vaccines against cancer and viral infections in murine and human systems

Cardiovascular Biology Laboratory
Developing novel, safe, and effective nucleic acid therapeutics

Individual Faculty

The following faculty members also conduct research in cancer genetics and biology:

Francis Ali-Osman, DSc
Jeffrey Marks, PhD

Immunology

The immunology program is centered on dendritic cell antigen presentation platforms and an extensive repertoire of immune monitoring technologies to support the development and clinical testing of novel immune-based therapies.

Labs

Laboratory for AIDS Vaccine Research and Development (Montefiori Lab) 
Identifies immunogens that generate broadly cross-reactive neutralizing antibodies against HIV-1 for inclusion in vaccines

Nair Research Lab
Designs and tests novel vaccines against cancer and viral infections in murine and human systems

Immune Dysfunction and Evolutionary Mismatch
Focuses on the immune system and its role in biology and disease

Immune Responses and Virology
Works to understand host-pathogen interactions in HIV

Immunologic Signatures Laboratory
Develops innovative immune therapeutic approaches that apply to patients with HIV, emerging infections, and solid tumors

Individual Faculty

The following faculty members also conduct immunology research:

Chin Ho Chen, PhD
Guido Ferrari, MD

Molecular and Nano Therapeutics

Our researchers apply these state-of-the-art technologies to the development of novel therapeutic strategies for cancer and autoimmune and infectious diseases.

Labs

Devi Research Lab
Studying basic and fundamental mechanisms of apoptosis, or programmed cell death

Endocrine Neoplasia Laboratory
Investigating how tumor-specific dysregulation of the pRB signaling pathway affects downstream gene expression and the cellular response to DNA damage

Cardiovascular Biology Laboratory
Developing novel, safe, and effective nucleic acid therapeutics

Individual Faculty

Chin Ho Chen, PhD

Transplantation

This program aims to understand barriers in solid organ transplantation, particularly abdominal organ transplants.

Parker Research Lab
Investigating a particular interest in the broad scientific issues surrounding abdominal organ transplants