Basic Research

Our investigations of the basic mechanisms behind such processes as fibrosis, tissue engineering, regenerative medicine, and angiogenesis are ultimately leading to better outcomes for surgical patients.

To learn more, please click on a research program below.

Adipose Determinants of Breast Cancer Progression

This collaborative program studies ASC contributions to breast cancer progression. The goal is to identify therapies for targeting ASC signaling pathways that contribute to breast cancer initiation/progression.

Bioengineering and Regenerative Medicine

This research initiative seeks to harness the angiogenic potential of adipose-derived stem cells, which may have application to ischemic flaps and acellular materials.

Fibrosis and Wound Healing

This laboratory investigates the mechanisms of fibrosis and tissue remodeling and aims to develop a novel small molecule inhibitor to prevent fibrocontractile disease progression. There is a large unmet need for an effective pharmaceutical to prevent fibrosis.

Skin Regeneration and Wound Healing

This research program seeks to understand the mechanisms of skin regeneration in zebrafish in order to develop novel regenerative strategies for human wound healing and diseases of the skin.

Vascularized Composite Allotransplantation

Vascularized composite allotransplantation (VCA) refers to the transplantation of multiple tissues, such as skin, muscle, tendon, nerve, and bone, as a functional unit (e.g. a hand). This laboratory aims to facilitate the translation of VCA from the bench to the bedside.