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Christopher Ritchie Mantyh, MD

Chief, Section of Gastrointestinal and Colorectal Surgery
Professor of Surgery
Office: 7676 Hosp North Hafs Building, Durham, NC 27710
Campus Mail: DUMC Box 3117 Med Ctr, Durham, NC 27710

Neurogenic inflammation
Ulcerative colitis
Crohn's disease
Vanilloid receptor
Substance P
Intestinal motility
Colorectal cancer outcomes
Colon cancer
Rectal cancer

Education and Training

  • Resident, Surgery, Duke University, 1991 - 1998
  • M.D., University of Wisconsin - Madison, 1991


Freischlag, Kyle, L. Olivere, M. Turner, M. Adam, C. Mantyh, and J. Migaly. “Does Fragmentation of Care in Locally Advanced Rectal Cancer Increase Patient Mortality?” J Gastrointest Surg 25, no. 5 (May 2021): 1287–96.

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Terrando, Niccolò, John J. Park, Michael Devinney, Cliburn Chan, Mary Cooter, Pallavi Avasarala, Joseph P. Mathew, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep 11, no. 1 (February 4, 2021): 3047.

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VanDusen, Keith W., Yi-Ju Li, Victor Cai, Ashley Hall, Sarah Hiles, J Will Thompson, M Arthur Moseley, et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis 80, no. 3 (2021): 1281–97.

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Gilmore, Brian, Mohamed A. Adam, Kristen Rhodin, Megan C. Turner, Brian Ezekian, Christopher R. Mantyh, and John Migaly. “Evolution of minimally invasive surgery for rectal cancer: update from the national cancer database.” Surg Endosc 35, no. 1 (January 2021): 275–90.

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Somarelli, Jason A., Roham Salman Roghani, Ali Sanjari Moghaddam, Beatrice C. Thomas, Gabrielle Rupprecht, Kathryn E. Ware, Erdem Altunel, et al. “A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer.” Mol Cancer Ther 19, no. 12 (December 2020): 2516–27.

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Corrigan, K. L., C. D. Jacobs, H. Williamson, S. Behrens, S. D. Hsu, C. G. Willett, C. R. Mantyh, G. Suneja, and B. Czito. “Differences in Clinicopathologic Features and Response to Neoadjuvant Radiotherapy for Early- Versus Late-Onset Stage II-III Rectal Adenocarcinoma.” In International Journal of Radiation Oncology Biology Physics, 108:E623–E623, 2020.


PelvEx Collaborative, L Ebony. “Simultaneous pelvic exenteration and liver resection for primary rectal cancer with synchronous liver metastases: results from the PelvEx Collaborative.” Colorectal Dis 22, no. 10 (October 2020): 1258–62.

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PelvEx Collaborative, D. C. “The impact of the COVID-19 pandemic on the Management of Locally Advanced Primary/Recurrent Rectal Cancer.” Br J Surg 107, no. 11 (October 2020): e547–48.

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