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Christopher Ritchie Mantyh, MD

Chief, Section of Gastrointestinal and Colorectal Surgery
Professor of Surgery
Division: 
Surgical Oncology
Section: 
Colorectal Surgery
Program: 
Complex General Surgical Oncology Fellowship
General Surgery Residency Program
Reconstructive Urology and Genitourinary Cancer Survivorship Fellowship
Office: 7676 Hosp North Hafs Building, Durham, NC 27710
Campus Mail: DUMC Box 3117 Med Ctr, Durham, NC 27710

Neurogenic inflammation
Ulcerative colitis
Crohn's disease
Neuropeptides
Receptors
Vanilloid receptor
Substance P
Intestinal motility
Colorectal cancer outcomes
Colon cancer
Rectal cancer

Education and Training

  • Resident, Surgery, Duke University, 1991 - 1998
  • M.D., University of Wisconsin - Madison, 1991

Selected Grants

Publications

Somarelli, Jason A., Roham Salman Roghani, Ali Sanjari Moghaddam, Beatrice C. Thomas, Gabrielle Rupprecht, Kathryn E. Ware, Erdem Altunel, et al. “A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer.” Mol Cancer Ther, November 6, 2020. https://doi.org/10.1158/1535-7163.MCT-20-0454.

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PelvEx Collaborative, Lawrence. “Simultaneous pelvic exenteration and liver resection for primary rectal cancer with synchronous liver metastases: results from the PelvEx Collaborative.” Colorectal Dis 22, no. 10 (October 2020): 1258–62. https://doi.org/10.1111/codi.15064.

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Kelly, M. E., A. Agj, N. Abdul Aziz, N. Abecasis, M. Abraham-Nordling, T. Akiyoshi, W. Alberda, et al. “The global cost of pelvic exenteration: in-hospital perioperative costs.” British Journal of Surgery 107, no. 11 (October 1, 2020): e470–71. https://doi.org/10.1002/bjs.11924.

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Chok, A. Y., C. Kontovounisios, S. Rasheed, M. E. Kelly, A. Agj, N. Abdul Aziz, N. Abecasis, et al. “The impact of the COVID-19 pandemic on the Management of Locally Advanced Primary/Recurrent Rectal Cancer.” British Journal of Surgery 107, no. 11 (October 1, 2020): e547–48. https://doi.org/10.1002/bjs.11893.

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Freischlag, Kyle, L. Olivere, M. Turner, M. Adam, C. Mantyh, and J. Migaly. “Does Fragmentation of Care in Locally Advanced Rectal Cancer Increase Patient Mortality?” J Gastrointest Surg, August 4, 2020. https://doi.org/10.1007/s11605-020-04760-x.

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PelvEx Collaborative, Michael D. “Predicting outcomes of pelvic exenteration using machine learning.” Colorectal Disease : The Official Journal of the Association of Coloproctology of Great Britain and Ireland, July 5, 2020. https://doi.org/10.1111/codi.15235.

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Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.

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Turner, M. C., O. Jawitz, M. A. Adam, E. Srinivasan, D. Niedzwiecki, J. Migaly, D. A. Fisher, and C. R. Mantyh. “Comparison of survival of stage I-III colon cancer by travel distance and hospital volume.” Techniques in Coloproctology 24, no. 7 (July 2020): 703–10. https://doi.org/10.1007/s10151-020-02207-8.

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Aronson, Solomon, Gavin Martin, Padma Gulur, Mike E. Lipkin, Sandhya A. Lagoo-Deenadayalan, Christopher R. Mantyh, David E. Attarian, Joseph P. Mathew, and Allan D. Kirk. “Preoperative Optimization: A Continued Call to Action.” Anesth Analg 130, no. 4 (April 2020): 808–10. https://doi.org/10.1213/ANE.0000000000004492.

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Gilmore, Brian, Mohamed A. Adam, Kristen Rhodin, Megan C. Turner, Brian Ezekian, Christopher R. Mantyh, and John Migaly. “Evolution of minimally invasive surgery for rectal cancer: update from the national cancer database.” Surg Endosc, February 28, 2020. https://doi.org/10.1007/s00464-020-07393-y.

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