Skip to main content

Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Gastrell, Philip, Jinny Cho, and Bruce Klitzman. “472. Low-Shear Sodding of an Implantable Expanded Polytetrafluoroethylene Scaffold with a Rat Adipose-Derived Stromal-Vascular Fraction.” In Molecular Therapy, 23:S187–S187. Elsevier BV, 2015. https://doi.org/10.1016/s1525-0016(16)34081-3.

Full Text

Boico, Alina, Eugenia Cho, Lynne Liao, Janna Register, Andrew Fales, Natalie Wisnewski, Sulolit Pradhan, Tuan Vo-Dihn, Gregory Palmer, and Bruce Klitzman. “Characterization of Inflammatory Cell Response to Implanted Porous P-HEMA in the Dermis Vs Subcutaneous Tissue.” In Faseb Journal, Vol. 29. FEDERATION AMER SOC EXP BIOL, 2015.

Scholars@Duke

Gastrell, Philip, Jinny Cho, and Bruce Klitzman. “Low-shear Sodding of an Implantable Expanded Polytetrafluoroethylene Scaffold with a Rat Adipose-derived Stromal-vascular Fraction.” In Faseb Journal, Vol. 29, 2015.

Scholars@Duke

Liao, Lin, Eugenia Cho, Alina Boico, Janna Register, Andrew Fales, Kristen Helton, Natalie Wisniewski, Tuan Vo-Dinh, Gregory Palmer, and Bruce Klitzman. “Vascularization of Porous PolyHEMA Scaffolds.” In Faseb Journal, Vol. 29. FEDERATION AMER SOC EXP BIOL, 2015.

Scholars@Duke

Ibrahim, M. M., M. A. Medina, J. Bond, A. Bergeron, L. Chen, C. Quiles, G. Kokosis, et al. “FOREIGN BODY RESPONSE TO FIVE COMMON SUBCUTANEOUS IMPLANTS.” In Wound Repair and Regeneration, 23:A27–A27. WILEY-BLACKWELL, 2015.

Scholars@Duke

Ibrahim, M. M., Z. Wu, and B. Klitzman. “NOVEL IMPLANTABLE OPTICAL OXYGEN MONITOR TO DETECT FLAP VIABILITY.” In Wound Repair and Regeneration, 23:A26–A26. WILEY-BLACKWELL, 2015.

Scholars@Duke

Ibrahim, Mohamed Magdy, Jennifer Bond, Andrew Bergeron, Kyle J. Miller, Tosan Ehanire, Carlos Quiles, Elizabeth R. Lorden, et al. “A novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies.” Wound Repair Regen 22, no. 6 (November 2014): 755–64. https://doi.org/10.1111/wrr.12238.

Full Text

Brown, Nga L., Michael B. Rose, Gert Blueschke, Eugenia H. Cho, Mark H. Schoenfisch, Detlev Erdmann, and Bruce Klitzman. “Bioburden after Staphylococcus aureus inoculation in type 1 diabetic rats undergoing internal fixation.” Plast Reconstr Surg 134, no. 3 (September 2014): 412e-419e. https://doi.org/10.1097/PRS.0000000000000434.

Full Text

Cho, Eugenia, Alina Boico, Nga Brown, Natalie Wisniewski, Kristen Helton, Janna Register, Andrew Fales, et al. “Tissue integration of porous polyHEMA scaffold.” In Faseb Journal, Vol. 28. FEDERATION AMER SOC EXP BIOL, 2014.

Scholars@Duke

Ibrahim, Mohamed M., Jennifer Bond, Andrew Bergeron, Kyle J. Miller, Tosan Ehanire, Carlos Quiles, Mark Fisher, et al. “Abstract 34: a novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies.” In Plast Reconstr Surg, 133:44–45, 2014. https://doi.org/10.1097/01.prs.0000445067.48096.d1.

Full Text

Pages