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Drs. Zachary Hartman and Kim Lyerly Receive $1M in Funding for Breast Cancer Research

Monday, February 12, 2018
Microscope with chemical compound for estrogen overlay

The Congressionally Directed Medical Research Program (CDMRP) has awarded a grant for continued breast cancer research to Zachary Hartman, PhD, Assistant Professor of Surgery. Dr. Hartman, a member of the Division of Surgical Sciences, will collaborate with H. Kim Lyerly, MD, Professor of Surgery, to study the treatment and prevention of estrogen receptor–positive (ER+) breast cancer.

ER+ cancer typically responds to endocrine therapy initially, but in many patients the tumor cells eventually develop endocrine resistance. Dr. Hartman’s research will test the use of a neoepitope subunit vaccine that targets the mutated estrogen receptors of the cells. Combined with standard-of-care hormone treatments, the vaccine has the potential to prevent cancer growth.

The CDMRP has awarded $1,183,281 for the research project, titled “A Neoepitope Subunit Vaccine Targeting the Mutated Estrogen Receptor Ligand Binding Domain to Treat and Prevent Endocrine-Resistant ER+ Breast Cancer.”