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Herbert Kim Lyerly, MD

George Barth Geller Distinguished Professor
Professor of Surgery
Professor in Immunology
Professor of Pathology
Office: 203 Research Drive, Rm 433B, Box 2606, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Education and Training

  • M.D., University of California at Los Angeles, 1983

Selected Grants

Publications

Bhatnagar, Vishal, Stacie Hudgens, Elisabeth Piault-Louis, Lee Jones, Julia A. Beaver, H Kim Lyerly, Gregory Reaman, Thomas Fleming, and Paul G. Kluetz. “Patient-Reported Outcomes in Oncology Clinical Trials: Stakeholder Perspectives from the Accelerating Anticancer Agent Development and Validation Workshop 2019.” The Oncologist, May 28, 2020. https://doi.org/10.1634/theoncologist.2020-0062.

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Kaneko, Kensuke, Takuya Osada, Michael A. Morse, William R. Gwin, Joshua D. Ginzel, Joshua C. Snyder, Xiao-Yi Yang, et al. “Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors.” Commun Biol 3, no. 1 (May 8, 2020): 226. https://doi.org/10.1038/s42003-020-0956-7.

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Trotter, Timothy N., Casey W. Shuptrine, Li-Chung Tsao, Robert D. Marek, Chaitanya Acharya, Jun-Ping Wei, Xiao-Yi Yang, et al. “IL-26, a non-canonical mediator of DNA inflammatory stimulation, promotes TNBC engraftment and progression in association with neutrophils.” Cancer Res, May 4, 2020. https://doi.org/10.1158/0008-5472.CAN-18-3825.

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Tsao, Li-Chung, Herbert Kim Lyerly, and Zachary Hartman. “Trastuzumab therapy suppresses HER2+breast tumor growth through inducing ADCP by tumor-associated macrophages and synergizes with CD47 checkpoint blockade.” In Cancer Immunology Research, 8:84–84. AMER ASSOC CANCER RESEARCH, 2020.

Scholars@Duke

Trotter, Timothy N., Cong-Xiao Liu, Tao Wang, H Kim Lyerly, and Zachary C. Hartman. “Dormant breast tumor cells avoid the adaptive immune system through regulation of the immune and tumor microenvironment.” In Cancer Immunology Research, 8:139–40. AMER ASSOC CANCER RESEARCH, 2020.

Scholars@Duke

Hwang, Bin-Jin, Li-Chung Tsao, Gabriel DeLeon, Junping Wei, Xiao-Yi Yang, Gangjun Lei, Tao Wang, Michael M. Morse, Herbert Kim Lyerly, and Zachary Conrad Hartman. “Overexpression of MAVS stimulates antitumor immunity and significantly reduces tumor growth of immune-insensitive colorectal cancer in vivo.” In Cancer Immunology Research, 8:24–25. AMER ASSOC CANCER RESEARCH, 2020.

Scholars@Duke

Hwang, Bin-Jin, Li-Chung Tsao, Gabriel DeLeon, Junping Wei, Xiao-Yi Yang, Gangjun Lei, Tao Wang, Michael M. Morse, Herbert Kim Lyerly, and Zachary Conrad Hartman. “PR2 Overexpression of MAVS stimulates antitumor immunity and significantly reduces tumor growth of immune-insensitive colorectal cancer in vivo.” In Cancer Immunology Research, 8:53–54. AMER ASSOC CANCER RESEARCH, 2020.

Scholars@Duke

Zhou, Xinna, Guoliang Qiao, Jun Ren, Xiaoli Wang, Shuo Wang, Siyu Zhu, Yanhua Yuan, Michael A. Morse, Amy Hobeika, and Herbert Kim Lyerly. “Adoptive immunotherapy with autologous T-cell infusions reduces opioid requirements in advanced cancer patients.” Pain 161, no. 1 (January 2020): 127–34. https://doi.org/10.1097/j.pain.0000000000001702.

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Tsao, Li-Chung, Erika J. Crosby, Timothy N. Trotter, Pankaj Agarwal, Bin-Jin Hwang, Chaitanya Acharya, Casey W. Shuptrine, et al. “CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis.” Jci Insight 4, no. 24 (December 19, 2019). https://doi.org/10.1172/jci.insight.131882.

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Boone, Peter G., Lauren K. Rochelle, Joshua D. Ginzel, Veronica Lubkov, Wendy L. Roberts, P. J. Nicholls, Cheryl Bock, et al. “A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.” Nat Commun 10, no. 1 (December 2, 2019): 5490. https://doi.org/10.1038/s41467-019-13330-y.

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