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Herbert Kim Lyerly, MD

George Barth Geller Distinguished Professor of Immunology
Professor of Surgery
Professor in Immunology
Professor of Pathology
Office: 203 Research Drive, Rm 433B, Box 2606, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Education and Training

  • M.D., University of California - Los Angeles, 1983

Selected Grants

Publications

Telli, Melinda L., Hiroshi Nagata, Irene Wapnir, Chaitanya R. Acharya, Kaitlin Zablotsky, Bernard A. Fox, Carlo B. Bifulco, et al. “Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy.” Clin Cancer Res, February 16, 2021. https://doi.org/10.1158/1078-0432.CCR-20-3944.

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Wang, Jie, Takuya Osada, Michael A. Morse, Frank Calzone, Hai Yan, Dung Thai, and H Kim Lyerly. “Targeting the glucagon receptor signaling pathway as a novel strategy to counteract PI3K inhibitor induced hyperglycemia while sustaining tumor PI3K inhibition.” Leuk Lymphoma, February 12, 2021, 1–6. https://doi.org/10.1080/10428194.2021.1881504.

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Crosby, Erika J., Hiroshi Nagata, Melinda L. Telli, Chaitanya R. Acharya, Irene Wapnir, Kaitlin Zablotsky, Erica Browning, et al. “Intratumoral delivery of tavokinogene telseplasmid (plasmid IL-12) and electroporation induces an immune signature that predicts successful combination in patients.” In Cancer Research, Vol. 81, 2021.

Scholars@Duke

Crosby, Erika J., H Kim Lyerly, and Zachary C. Hartman. “Cancer vaccines: the importance of targeting oncogenic drivers and the utility of combinations with immune checkpoint inhibitors.” Oncotarget 12, no. 1 (January 5, 2021): 1–3. https://doi.org/10.18632/oncotarget.27861.

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Wang, Jie, Michael Morse, Frank Calzone, Hai Yan, Zung Thai, Takuya Osada, and Herbert Lyerly. “Targeting the Glucagon Receptor Signaling Pathway As a Novel Strategy to Counteract PI3K Inhibitor Induced Hyperglycemia While Sustaining Tumor PI3K Inhibition.” In Blood, 136:4–5. American Society of Hematology, 2020. https://doi.org/10.1182/blood-2020-140576.

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Crosby, Erika, Hiroshi Nagata, Melinda Telli, Chaitanya Acharya, Irene Wapnir, Kaitlin Zablotsky, Erica Browning, et al. “789 Intratumoral plasmid IL-12 expands CD8+ T cells and induces a clinically validated CXCR3 signature in triple-negative breast cancer.” In Journal for Immunotherapy of Cancer, 8:A838–A838. BMJ, 2020. https://doi.org/10.1136/jitc-2020-sitc2020.0789.

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Crosby, Erika J., Amy C. Hobeika, Donna Niedzwiecki, Christel Rushing, David Hsu, Peter Berglund, Jonathan Smith, et al. “Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio.” J Immunother Cancer 8, no. 2 (November 2020). https://doi.org/10.1136/jitc-2020-001662.

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Bhatnagar, Vishal, Stacie Hudgens, Elisabeth Piault-Louis, Lee Jones, Julia A. Beaver, H Kim Lyerly, Gregory Reaman, Thomas Fleming, and Paul G. Kluetz. “Patient-Reported Outcomes in Oncology Clinical Trials: Stakeholder Perspectives from the Accelerating Anticancer Agent Development and Validation Workshop 2019.” Oncologist 25, no. 10 (October 2020): 819–21. https://doi.org/10.1634/theoncologist.2020-0062.

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Schrott, Rose, Maya Rajavel, Kelly Acharya, Zhiqing Huang, Chaitanya Acharya, Andrew Hawkey, Erica Pippen, H Kim Lyerly, Edward D. Levin, and Susan K. Murphy. “Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin.” Sci Rep 10, no. 1 (September 29, 2020): 16022. https://doi.org/10.1038/s41598-020-72783-0.

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Hafez, Navid, Hope S. Rugo, Margaret A. Tempero, Elizabeth Fox, Gregory H. Reaman, Herbert Kim Lyerly, Desiree Walker, and Patricia M. LoRusso. “Novel Therapeutic Interventions Early in the Disease Trajectory: Drug Development Beyond the Refractory Setting.” Clin Cancer Res 26, no. 18 (September 15, 2020): 4743–47. https://doi.org/10.1158/1078-0432.CCR-19-4035.

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