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Herbert Kim Lyerly, MD

George Barth Geller Professor
Professor of Surgery
Professor in Immunology
Associate Professor of Pathology
Office: 203 Research Drive, Rm 433B, Box 2606, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Education and Training

  • M.D., University of California at Los Angeles, 1983

Selected Grants

Publications

Zhou, X, Qiao, G, Wang, X, Song, Q, Morse, MA, Hobeika, A, Gwin, WR, Ren, J, and Lyerly, HK. "CYP1A1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine." Cancer chemotherapy and pharmacology 81, no. 2 (February 2018): 365-372.

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Song, Q, Ren, J, Zhou, X, Wang, X, Song, G, Hobeika, A, Yuan, Y, and Lyerly, HK. "Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study." Cytotherapy 20, no. 1 (January 2018): 126-133.

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Shuptrine, CW, Ajina, R, Fertig, EJ, Jablonski, SA, Kim Lyerly, H, Hartman, ZC, and Weiner, LM. "An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection." Cancer immunology, immunotherapy : CII 66, no. 12 (December 2017): 1529-1544.

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Osada, T, Kaneko, K, Gwin, WR, Morse, MA, Hobeika, A, Pogue, BW, Hartman, ZC, Hughes, PF, Haystead, T, and Lyerly, HK. "In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior." Clinical cancer research : an official journal of the American Association for Cancer Research 23, no. 24 (December 2017): 7531-7542.

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Jiang, N, Qiao, G, Wang, X, Morse, MA, Gwin, WR, Zhou, L, Song, Y, Zhao, Y, Chen, F, Zhou, X, Huang, L, Hobeika, A, Yi, X, Xia, X, Guan, Y, Song, J, Ren, J, and Lyerly, HK. "Dendritic Cell/Cytokine-Induced Killer Cell Immunotherapy Combined with S-1 in Patients with Advanced Pancreatic Cancer: A Prospective Study." Clinical cancer research : an official journal of the American Association for Cancer Research 23, no. 17 (September 2017): 5066-5073.

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Crowe, LB, Hughes, PF, Alcorta, DA, Osada, T, Smith, AP, Totzke, J, Loiselle, DR, Lutz, ID, Gargesha, M, Roy, D, Roques, J, Darr, D, Lyerly, HK, Spector, NL, and Haystead, TAJ. "A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo." ACS chemical biology 12, no. 4 (April 2017): 1047-1055.

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Snyder, JC, Rochelle, LK, Ray, C, Pack, TF, Bock, CB, Lubkov, V, Lyerly, HK, Waggoner, AS, Barak, LS, and Caron, MG. "Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness." The Journal of biological chemistry 292, no. 17 (April 2017): 7208-7222.

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Mook, RA, Ren, X-R, Wang, J, Piao, H, Barak, LS, Kim Lyerly, H, and Chen, W. "Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis." Bioorganic & medicinal chemistry 25, no. 6 (March 2017): 1804-1816.

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Sauer, SJ, Tarpley, M, Shah, I, Save, AV, Lyerly, HK, Patierno, SR, Williams, KP, and Devi, GR. "Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells." Carcinogenesis 38, no. 3 (March 2017): 252-260.

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Hartman, Z, Crosby, E, Wei, J-P, Yang, X-Y, Lei, G-J, Wang, T, Liu, C-X, Agarwal, P, Morse, M, and Lyerly, H. "Abstract P2-04-27: CTLA-4 and PD-1 checkpoint inhibitors enhance individually tailored adaptive anti-tumor immune responses to overcome tumor immunosuppression and effectively treat triple-negative breast cancer." February 15, 2017.

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