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Herbert Kim Lyerly, MD

George Barth Geller Professor
Professor of Surgery
Professor in Immunology
Professor of Pathology
Office: 203 Research Drive, Rm 433B, Box 2606, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Education and Training

  • M.D., University of California at Los Angeles, 1983

Selected Grants

Publications

Qiao, G, Wang, X, Zhou, L, Zhou, X, Song, Y, Wang, S, Zhao, L, Morse, MA, Hobeika, A, Song, J, Yi, X, Xia, X, Ren, J, and Lyerly, HK. "Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 25, no. 5 (March 2019): 1494-1504.

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Wang, J, Ren, X-R, Piao, H, Zhao, S, Osada, T, Premont, RT, Mook, RA, Morse, MA, Lyerly, HK, and Chen, W. "Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy." The Biochemical Journal 476, no. 3 (February 8, 2019): 535-546.

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Cecchini, M, Rubin, EH, Blumenthal, GM, Ayalew, K, Burris, HA, Russell-Einhorn, M, Dillon, H, Lyerly, HK, Reaman, GH, Boerner, S, and LoRusso, PM. "Challenges with Novel Clinical Trial Designs: Master Protocols." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research (January 29, 2019).

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Crosby, EJ, Gwin, WR, Blackwell, K, Marcom, PK, Chang, S, Maecker, HT, Broadwater, G, Hyslop, TM, Kim, S, Rogatko, A, Lubkov, V, Snyder, JC, Osada, T, Hobeika, A, Morse, MA, Lyerly, HK, and Hartman, ZC. "Vaccine-induced memory CD8+ T cells provide clinical benefit in HER2 expressing breast cancer: a mouse to human translational study." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research (January 11, 2019).

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Mook, RA, Wang, J, Ren, X-R, Piao, H, Lyerly, HK, and Chen, W. "Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype." Bioorganic & Medicinal Chemistry Letters 29, no. 2 (January 2019): 317-321.

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Lyerly, HK, Osada, T, and Hartman, ZC. "Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 25, no. 1 (January 2019): 9-11.

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Lyerly, HK, Ren, J, Canetta, R, Kim, GH, Nagai, S, Yamaguchi, T, Hatogai, K, Katayama, H, Da Rocha Dias, S, McManus, D, Soltys, K, Yang, Z, Olopade, O, Goodman, N, Reaman, G, and Gross, T. "Global Development of Anticancer Therapies for Rare Cancers, Pediatric Cancers, and Molecular Subtypes of Common Cancers." Journal of Global Oncology 4 (December 2018): 1-11.

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Wang, J, Mook, RA, Ren, X-R, Zhang, Q, Jing, G, Lu, M, Spasojevic, I, Lyerly, HK, Hsu, D, and Chen, W. "Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth." Bioorganic & Medicinal Chemistry 26, no. 20 (November 2018): 5435-5442.

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Zhao, Y, Qiao, G, Wang, X, Song, Y, Zhou, X, Jiang, N, Zhou, L, Huang, H, Zhao, J, Morse, MA, Hobeika, A, Ren, J, and Lyerly, HK. "Combination of DC/CIK adoptive T cell immunotherapy with chemotherapy in advanced non-small-cell lung cancer (NSCLC) patients: a prospective patients' preference-based study (PPPS)." Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (October 29, 2018).

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Crosby, EJ, Lei, G, Wei, J, Yang, XY, Wang, T, Liu, C-X, Lyerly, HK, and Hartman, ZC. "Abstract A22: Augmentation of a novel adenoviral vaccine strategy by checkpoint inhibitors." Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; October 1-4, 2017; Boston, MA.: American Association for Cancer Research, September 2018.

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