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Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Selected Grants

Publications

Onor, Ifeanyichukwu O., Sarah B. Todd, Erika Meredith, Sebastian D. Perez, Aneesh K. Mehta, G. Marshall Lyon, Stuart J. Knechtle, and Steven I. Hanish. “Evaluation of clinical outcomes of prophylactic versus preemptive cytomegalovirus strategy in liver transplant recipients.” Transpl Int 26, no. 6 (June 2013): 592–600. https://doi.org/10.1111/tri.12101.

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Squires, Malcolm H., Steven Hanish, Sarah B. Fisher, Cristen Garrett, David Kooby, Juan M. Sarmiento, Kenneth Cardona, et al. “Transplant Versus Resection for the Management of Hepatocellular Carcinoma in the Post-2006 MELD Exception Era At a Single Institution in the Southeast UNOS Region.” In Gastroenterology, 144:S1058–S1058. W B SAUNDERS CO-ELSEVIER INC, 2013.

Scholars@Duke

Badell, I. R., S. I. Hanish, C. B. Hughes, W. R. Hewitt, R. T. Chung, J. R. Spivey, and S. J. Knechtle. “Domino liver transplantation in maple syrup urine disease: a case report and review of the literature.” Transplant Proc 45, no. 2 (March 2013): 806–9. https://doi.org/10.1016/j.transproceed.2012.04.031.

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Dhirapong, Amy, Guo-Xiang Yang, Steven Nadler, Weici Zhang, Koichi Tsuneyama, Patrick Leung, Stuart Knechtle, et al. “Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis.” Hepatology 57, no. 2 (February 2013): 708–15. https://doi.org/10.1002/hep.26067.

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Kawata, Kazuhito, Masanobu Tsuda, Guo-Xiang Yang, Weici Zhang, Hajime Tanaka, Koichi Tsuneyama, Patrick Leung, et al. “Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis.” In Plos One, 8:e74225, 2013. https://doi.org/10.1371/journal.pone.0074225.

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Morris, P. J., and S. J. Knechtle. “Kidney transplantation-principles and practice, seventh edition.” Kidney Transplantation Principles and Practice, Seventh Edition, January 1, 2013, 1–758.

Scholars@Duke

Velazquez, Victoria M., Huiming Hon, Chris Ibegbu, Stuart J. Knechtle, Allan D. Kirk, and Arash Grakoui. “Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection.” Hepatology 56, no. 6 (December 2012): 2071–81. https://doi.org/10.1002/hep.25904.

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