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Knechtle Lab

Photo of Stuart Johnston Knechtle, MD

Stuart Johnston Knechtle, MD

Office: 2301 Erwin Road Durham, NC 27710
Phone: 919-613-9687

Scientific Focus

Two unsolved problems in organ transplantation are 1) injury caused by antibody directed at the donor organ; and 2) recurrence of autoimmune disease after transplantation. Neither of these immunologic injuries is well addressed by current immunosuppressive therapy, and both prevent successful long-term allograft function. Our laboratory works in animal models to address the first of these problems and is engaged in human clinical trials to address the second.

Two strategies that we have considerable published experience include lymphocyte depletion and costimulation blockade. At this time we are particularly focused on strategies to address the B cell or plasma cell responsible for producing antibodies. We are developing strategies to safely lower the level of antibody in pre-sensitized hosts to permit successful transplantation in the setting of prior immunization to donor MHC antigens.

Latest Publications

Ezekian, Brian, Paul M. Schroder, Michael S. Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, et al. “Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients..” J Am Soc Nephrol 30, no. 12 (December 2019): 2399–2411.

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Schmitz, Robin, Zachary Fitch, Paul Schroder, Ashley Choi, Annette Jackson, Stuart Knechtle, and Jean Kwun. “B cells in transplant tolerance and rejection: friends or foes?.” Transpl Int, November 9, 2019.

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Gao, Qimeng, Michael S. Mulvihill, Uwe Scheuermann, Robert P. Davis, John Yerxa, Babatunde A. Yerokun, Matthew G. Hartwig, Debra L. Sudan, Stuart J. Knechtle, and Andrew S. Barbas. “Improvement in Liver Transplant Outcomes From Older Donors: A US National Analysis..” Ann Surg 270, no. 2 (August 2019): 333–39.

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Schroder, Paul M., Zachary W. Fitch, Robin Schmitz, Ashley Y. Choi, Jean Kwun, and Stuart J. Knechtle. “The past, present, and future of costimulation blockade in organ transplantation..” Curr Opin Organ Transplant 24, no. 4 (August 2019): 391–401.

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