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Knechtle Lab

Photo of Stuart Johnston Knechtle, MD

Stuart Johnston Knechtle, MD

Office: 2301 Erwin Road Durham, NC 27710
Phone: 919-613-9687
Fax: 
919-684-8716

Scientific Focus

Two unsolved problems in organ transplantation are 1) injury caused by antibody directed at the donor organ; and 2) recurrence of autoimmune disease after transplantation. Neither of these immunologic injuries is well addressed by current immunosuppressive therapy, and both prevent successful long-term allograft function. Our laboratory works in animal models to address the first of these problems and is engaged in human clinical trials to address the second.

Two strategies that we have considerable published experience include lymphocyte depletion and costimulation blockade. At this time we are particularly focused on strategies to address the B cell or plasma cell responsible for producing antibodies. We are developing strategies to safely lower the level of antibody in pre-sensitized hosts to permit successful transplantation in the setting of prior immunization to donor MHC antigens.

Latest Publications

Dangi, Anil, Shuangjin Yu, Frances T. Lee, Melanie Burnette, Stuart Knechtle, Jean Kwun, and Xunrong Luo. “Donor apoptotic cell-based therapy for effective inhibition of donor-specific memory T and B cells to promote long-term allograft survival in allosensitized recipients.” Am J Transplant 20, no. 10 (October 2020): 2728–39. https://doi.org/10.1111/ajt.15878.

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Kwun, Jean, and Stuart Knechtle. “Pharmacological approaches to antibody-mediated rejection-Are we getting closer?” American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20, no. 10 (October 2020): 2637–38. https://doi.org/10.1111/ajt.16061.

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Moris, Dimitrios, Brian I. Shaw, Jared Gloria, Samuel J. Kesseli, Mariya L. Samoylova, Robin Schmitz, Miriam Manook, et al. “Textbook Outcomes in Liver Transplantation.” World J Surg 44, no. 10 (October 2020): 3470–77. https://doi.org/10.1007/s00268-020-05625-9.

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Schroder, Paul M., Robin Schmitz, Zachary W. Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y. Choi, Miriam Manook, et al. “Preoperative Carfilzomib and Lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.” Kidney Int, September 5, 2020. https://doi.org/10.1016/j.kint.2020.08.020.

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