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Knechtle Lab

Photo of Stuart Johnston Knechtle, MD

Stuart Johnston Knechtle, MD

Office: 2301 Erwin Road Durham, NC 27710
Phone: 919-613-9687

Scientific Focus

Two unsolved problems in organ transplantation are 1) injury caused by antibody directed at the donor organ; and 2) recurrence of autoimmune disease after transplantation. Neither of these immunologic injuries is well addressed by current immunosuppressive therapy, and both prevent successful long-term allograft function. Our laboratory works in animal models to address the first of these problems and is engaged in human clinical trials to address the second.

Two strategies that we have considerable published experience include lymphocyte depletion and costimulation blockade. At this time we are particularly focused on strategies to address the B cell or plasma cell responsible for producing antibodies. We are developing strategies to safely lower the level of antibody in pre-sensitized hosts to permit successful transplantation in the setting of prior immunization to donor MHC antigens.

Latest Publications

Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Yoon, J, Yi, JS, Iwakoshi, N, Gibby, A, Hong, JJ, Farris, AB, Kirk, AD, and Knechtle, SJ. "Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates." Blood advances 1, no. 24 (November 2017): 2115-2119.

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Ezekian, B, Mulvihill, MS, Freischlag, K, Yerokun, BA, Davis, RP, Hartwig, MG, Knechtle, SJ, and Barbas, AS. "Elevated HbA1c in donor organs from patients without a diagnosis of diabetes portends worse liver allograft survival." Clinical transplantation 31, no. 9 (September 2017).

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Dendy, MS, Camacho, JC, Ludwig, JM, Krasinskas, AM, Knechtle, SJ, and Kim, HS. "Infiltrative Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Treated With a Single High-Dose Y90 Radioembolization and Subsequent Liver Transplantation Without a Recurrence." Transplantation direct 3, no. 9 (September 2017): e206-.

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Manook, M, Kwun, J, Burghuber, C, Samy, K, Mulvihill, M, Yoon, J, Xu, H, MacDonald, AL, Freischlag, K, Curfman, V, Branum, E, Howell, D, Farris, AB, Smith, RA, Sacks, S, Dorling, A, Mamode, N, and Knechtle, SJ. "Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 8 (August 2017): 2055-2064.

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