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Knechtle Lab

Photo of Stuart Johnston Knechtle, MD

Stuart Johnston Knechtle, MD

Office: 2301 Erwin Road Durham, NC 27710
Phone: 919-613-9687

Scientific Focus

Two unsolved problems in organ transplantation are 1) injury caused by antibody directed at the donor organ; and 2) recurrence of autoimmune disease after transplantation. Neither of these immunologic injuries is well addressed by current immunosuppressive therapy, and both prevent successful long-term allograft function. Our laboratory works in animal models to address the first of these problems and is engaged in human clinical trials to address the second.

Two strategies that we have considerable published experience include lymphocyte depletion and costimulation blockade. At this time we are particularly focused on strategies to address the B cell or plasma cell responsible for producing antibodies. We are developing strategies to safely lower the level of antibody in pre-sensitized hosts to permit successful transplantation in the setting of prior immunization to donor MHC antigens.

Latest Publications

Kwun, Jean, Jie Li, Clay Rouse, Jae Berm Park, Alton B. Farris, Maragatha Kuchibhatla, Joseph W. Turek, Stuart J. Knechtle, Allan D. Kirk, and M Louise Markert. “Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.” Jci Insight 5, no. 11 (June 4, 2020).

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Moris, Dimitrios, Brian I. Shaw, Jared Gloria, Samuel J. Kesseli, Mariya L. Samoylova, Robin Schmitz, Miriam Manook, et al. “Textbook Outcomes in Liver Transplantation.” World J Surg, June 2, 2020.

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Sawitzki, Birgit, Paul N. Harden, Petra Reinke, Aurélie Moreau, James A. Hutchinson, David S. Game, Qizhi Tang, et al. “Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.” Lancet 395, no. 10237 (May 23, 2020): 1627–39.

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