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Paul Joseph Mosca, MD, PhD, MBA

Associate Professor of Surgery
Office: 10 Bryan Searle Drive, 466G Seeley G. Mudd Bldg, Durham, NC 27710
Campus Mail: DUMC 3966, 10 Bryan Searle Dr, 466G Seeley G Mudd, Durham, NC 27710

My research focuses on three areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy. A third area of interest is quality and patient safety with an emphasis on communication and work culture.

Education and Training

  • Assistant Professor, Surgery, Lehigh Valley Health Network, 2004 - 2010
  • Assistant Professor, Surgery, Duke University School of Medicine, 2002 - 2004
  • Chief Resident, Surgery, Duke University, 2001 - 2002
  • 2nd Year SAR, Surgery, Duke University, 2000 - 2001
  • Surgical Research Fellow, Surgery, Duke University, 1998 - 2000
  • Senior Assistant Resident, Surgery, Duke University, 1997 - 1998
  • Junior Assistant Resident, Surgery, Duke University, 1996 - 1997
  • Intern, Surgery, Duke University, 1995 - 1996
  • M.B.A., Desales University, 2011
  • M.D., University of Virginia, 1995
  • Ph.D., University of Virginia, 1994

Publications

Lin, H. B., R. Falchetto, P. J. Mosca, J. Shabanowitz, D. F. Hunt, and J. L. Hamlin. “Mimosine targets serine hydroxymethyltransferase.” J Biol Chem 271, no. 5 (February 2, 1996): 2548–56. https://doi.org/10.1074/jbc.271.5.2548.

Full Text

Mosca, P. J., H. B. Lin, and J. L. Hamlin. “Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells.” Nucleic Acids Res 23, no. 2 (January 25, 1995): 261–68. https://doi.org/10.1093/nar/23.2.261.

Full Text

Hamlin, J. L., P. J. Mosca, and V. V. Levenson. “Defining origins of replication in mammalian cells.” Biochim Biophys Acta 1198, no. 2–3 (December 30, 1994): 85–111. https://doi.org/10.1016/0304-419x(94)90008-6.

Full Text

MOSCA, P. J., P. A. DIJKWEL, and J. L. HAMLIN. “THE PLANT AMINO-ACID MIMOSINE MAY INHIBIT INITIATION AT ORIGINS OF REPLICATION IN CHINESE-HAMSTER CELLS (MOLECULAR AND CELLULAR BIOLOGY, VOL 12, PG 4375, 1992).” In Molecular and Cellular Biology, 13:1981–1981. AMER SOC MICROBIOLOGY, 1993.

Scholars@Duke

Mosca, P. J., P. A. Dijkwel, and J. L. Hamlin. “Erratum: The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells (Mol. Cell. Biol., Vol. 12, No. 10, p. 4375, (1992)).” Molecular and Cellular Biology, January 1, 1993.

Scholars@Duke

Mosca, P. J., P. A. Dijkwel, and J. L. Hamlin. “The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells.” Mol Cell Biol 12, no. 10 (October 1992): 4375–83. https://doi.org/10.1128/mcb.12.10.4375.

Full Text

Speicher, P., D. S. Tyler, and paul Mosca. “Management of In-transit Malignant Melanoma.” In Melanoma From Early Detection to Treatment, n.d.

Scholars@Duke

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