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Paul Joseph Mosca, MD, PhD, MBA

Associate Professor of Surgery
Office: 10 Bryan Searle Drive, 466G Seeley G. Mudd Bldg, Durham, NC 27710
Campus Mail: DUMC 3966, 10 Bryan Searle Dr, 466G Seeley G Mudd, Durham, NC 27710

My research focuses on three areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy. A third area of interest is quality and patient safety with an emphasis on communication and work culture.

Education and Training

  • Assistant Professor, Surgery, Lehigh Valley Health Network, 2004 - 2010
  • Assistant Professor, Surgery, Duke University School of Medicine, 2002 - 2004
  • Chief Resident, Surgery, Duke University, 2001 - 2002
  • 2nd Year SAR, Surgery, Duke University, 2000 - 2001
  • Surgical Research Fellow, Surgery, Duke University, 1998 - 2000
  • Senior Assistant Resident, Surgery, Duke University, 1997 - 1998
  • Junior Assistant Resident, Surgery, Duke University, 1996 - 1997
  • Intern, Surgery, Duke University, 1995 - 1996
  • M.B.A., Desales University, 2011
  • M.D., University of Virginia, 1995
  • Ph.D., University of Virginia, 1994

Publications

Morse, Michael A., Smita K. Nair, Paul J. Mosca, Amy C. Hobeika, Timothy M. Clay, Yuping Deng, David Boczkowski, et al. “Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA.” Cancer Invest 21, no. 3 (June 2003): 341–49. https://doi.org/10.1081/cnv-120018224.

Full Text

Mosca, Paul J., Timothy M. Clay, H. Kim Lyerly, and Michael A. Morse. “Current status of dendritic cell immunotherapy of malignancies.” Int Rev Immunol 22, no. 3–4 (May 2003): 255–81. https://doi.org/10.1080/08830180305223.

Full Text

Mosca, Paul J., H Kim Lyerly, C Denise Ching, Amy C. Hobeika, Timothy M. Clay, and Michael A. Morse. “Proteomics for monitoring immune responses to cancer vaccines.” Curr Opin Mol Ther 5, no. 1 (February 2003): 39–43.

Scholars@Duke

Mosca, Paul J., Amy C. Hobeika, Kirsten Colling, Timothy M. Clay, Elaine K. Thomas, Dania Caron, H Kim Lyerly, and Michael A. Morse. “Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand.” J Leukoc Biol 72, no. 3 (September 2002): 546–53.

Scholars@Duke

Morse, Michael A., David Rizzieri, Timothy T. Stenzel, Amy C. Hobeika, James J. Vredenburgh, Nelson J. Chao, Timothy M. Clay, Paul J. Mosca, and H Kim Lyerly. “Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants.” J Hematother Stem Cell Res 11, no. 4 (August 2002): 659–68. https://doi.org/10.1089/15258160260194802.

Full Text

Morse, Michael A., Paul J. Mosca, Timothy M. Clay, and H Kim Lyerly. “Dendritic cell maturation in active immunotherapy strategies.” Expert Opin Biol Ther 2, no. 1 (January 2002): 35–43. https://doi.org/10.1517/14712598.2.1.35.

Full Text

Colling, K. L., A. C. Hobeika, P. J. Mosca, T. M. Clay, H. K. Lyerly, and M. A. Morse. “Enumerating functionally mature monocyte-derived dendritic cells for use in cancer immunotherapy.” In Blood, 98:851A-851A. AMER SOC HEMATOLOGY, 2001.

Scholars@Duke

Hobeika, A. C., S. Peplinski, M. A. Morse, P. J. Mosca, T. C. Clay, and H. K. Lyerly. “Quantitating antigen specific T cell responses in peripheral blood: A comparison of peptide MHC tetramer, ELISpot and intracellular cytokine analysis.” In Blood, 98:23A-23A. AMER SOC HEMATOLOGY, 2001.

Scholars@Duke

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