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Paul Joseph Mosca, MD, PhD, MBA

Associate Professor of Surgery
Office: 10 Bryan Searle Drive, 466G Seeley G. Mudd Bldg, Durham, NC 27710
Campus Mail: DUMC 3966, 10 Bryan Searle Dr, 466G Seeley G Mudd, Durham, NC 27710

My research focuses on three areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy. A third area of interest is quality and patient safety with an emphasis on communication and work culture.

Education and Training

  • Assistant Professor, Surgery, Lehigh Valley Health Network, 2004 - 2010
  • Assistant Professor, Surgery, Duke University School of Medicine, 2002 - 2004
  • Chief Resident, Surgery, Duke University, 2001 - 2002
  • 2nd Year SAR, Surgery, Duke University, 2000 - 2001
  • Surgical Research Fellow, Surgery, Duke University, 1998 - 2000
  • Senior Assistant Resident, Surgery, Duke University, 1997 - 1998
  • Junior Assistant Resident, Surgery, Duke University, 1996 - 1997
  • Intern, Surgery, Duke University, 1995 - 1996
  • M.B.A., Desales University, 2011
  • M.D., University of Virginia, 1995
  • Ph.D., University of Virginia, 1994

Publications

Mosca, Paul J., and Gavin P. Robertson. “Augmentation of tumor-specific immunity by upregulation of apoptotic melanoma cell calreticulin expression.” Cancer Biol Ther, March 15, 2011. https://doi.org/10.4161/cbt.11.6.14697.

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Santillan, Alfredo A., Keith A. Delman, Georgia M. Beasley, Paul J. Mosca, Steven N. Hochwald, Stephen R. Grobmyer, Robert H. Andtbacka, et al. “Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis.” Ann Surg Oncol 16, no. 9 (September 2009): 2570–78. https://doi.org/10.1245/s10434-009-0563-9.

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Beasley, Georgia M., Abigail Caudle, Rebecca P. Petersen, Nicole S. McMahon, James Padussis, Paul J. Mosca, Jonathan S. Zager, et al. “A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.” J Am Coll Surg 208, no. 5 (May 2009): 706–15. https://doi.org/10.1016/j.jamcollsurg.2008.12.019.

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Sharma, Arati, Arun K. Sharma, Subbarao V. Madhunapantula, Dhimant Desai, Sung Jin Huh, Paul Mosca, Shantu Amin, and Gavin P. Robertson. “Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.” Clin Cancer Res 15, no. 5 (March 1, 2009): 1674–85. https://doi.org/10.1158/1078-0432.CCR-08-2214.

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Padussis, James C., Samuel N. Steerman, Douglas S. Tyler, and Paul J. Mosca. “Pharmacokinetics & drug resistance of melphalan in regional chemotherapy: ILP versus ILI.” Int J Hyperthermia 24, no. 3 (May 2008): 239–49. https://doi.org/10.1080/02656730701816410.

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Mosca, Paul J., Erik Teicher, Suresh P. Nair, and Barbara A. Pockaj. “Can surgeons improve survival in stage IV melanoma?” J Surg Oncol 97, no. 5 (April 1, 2008): 462–68. https://doi.org/10.1002/jso.20950.

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Posther, Katherine E., M Angelica Selim, Paul J. Mosca, Wilma E. Stanley, Jeffrey L. Johnson, Douglas S. Tyler, and Hilliard F. Seigler. “Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma.” Ann Surg Oncol 13, no. 5 (May 2006): 728–39. https://doi.org/10.1245/ASO.2006.03.091.

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