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Paul Joseph Mosca, MD, PhD, MBA

Associate Professor of Surgery
Office: 10 Bryan Searle Drive, 466G Seeley G. Mudd Bldg, Durham, NC 27710
Campus Mail: DUMC 3966, 10 Bryan Searle Dr, 466G Seeley G Mudd, Durham, NC 27710

My research focuses on three areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy. A third area of interest is quality and patient safety with an emphasis on communication and work culture.

Education and Training

  • Assistant Professor, Surgery, Lehigh Valley Health Network, 2004 - 2010
  • Assistant Professor, Surgery, Duke University School of Medicine, 2002 - 2004
  • Chief Resident, Surgery, Duke University, 2001 - 2002
  • 2nd Year SAR, Surgery, Duke University, 2000 - 2001
  • Surgical Research Fellow, Surgery, Duke University, 1998 - 2000
  • Senior Assistant Resident, Surgery, Duke University, 1997 - 1998
  • Junior Assistant Resident, Surgery, Duke University, 1996 - 1997
  • Intern, Surgery, Duke University, 1995 - 1996
  • M.B.A., Desales University, 2011
  • M.D., University of Virginia, 1995
  • Ph.D., University of Virginia, 1994


Jiang, B. S., G. M. Beasley, P. J. Speicher, B. Hanks, P. J. Mosca, A. Salama, and D. S. Tyler. “Immunotherapy Following Disease Progression after Regional Treatment of Melanoma.” Journal of Surgical Research 186, no. 2 (February 2014): 682–682.

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Dannull, Jens, N Rebecca Haley, Gary Archer, Smita Nair, David Boczkowski, Mark Harper, Nicole De Rosa, et al. “Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.” J Clin Invest 123, no. 7 (July 2013): 3135–45.

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Shetty, Gina, Georgia M. Beasley, Sara Sparks, Michael Barfield, Melanie Masoud, Paul J. Mosca, Scott K. Pruitt, et al. “Plasma cytokine analysis in patients with advanced extremity melanoma undergoing isolated limb infusion.” Ann Surg Oncol 20, no. 4 (April 2013): 1128–35.

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Beasley, Georgia M., Ketan Sharma, Joyce Wong, Mike Miller, Ryan S. Turley, Michael Lidsky, Melanie Masoud, et al. “A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion.” Cancer 118, no. 24 (December 15, 2012): 6136–43.

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Rialon, K. L., D. G. Blazer, A. P. Abernethy, and P. J. Mosca. “Surgery and the D-Word: Approaching the Topic of Death and Dying with Surgical Patients.” Journal of Palliative Care & Medicine 02, no. 03 (March 1, 2012): 108–108.

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Madhunapantula, SubbaRao V., Paul J. Mosca, and Gavin P. Robertson. “The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.” Cancer Biol Ther 12, no. 12 (December 15, 2011): 1032–49.

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