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Paul Joseph Mosca, MD, PhD, MBA

Associate Professor of Surgery
Office: 10 Bryan Searle Drive, 466G Seeley G. Mudd Bldg, Durham, NC 27710
Campus Mail: DUMC 3966, 10 Bryan Searle Dr, 466G Seeley G Mudd, Durham, NC 27710

My research focuses on three areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy. A third area of interest is quality and patient safety with an emphasis on communication and work culture.

Education and Training

  • Assistant Professor, Surgery, Lehigh Valley Health Network, 2004 - 2010
  • Assistant Professor, Surgery, Duke University School of Medicine, 2002 - 2004
  • Chief Resident, Surgery, Duke University, 2001 - 2002
  • 2nd Year SAR, Surgery, Duke University, 2000 - 2001
  • Surgical Research Fellow, Surgery, Duke University, 1998 - 2000
  • Senior Assistant Resident, Surgery, Duke University, 1997 - 1998
  • Junior Assistant Resident, Surgery, Duke University, 1996 - 1997
  • Intern, Surgery, Duke University, 1995 - 1996
  • M.B.A., Desales University, 2011
  • M.D., University of Virginia, 1995
  • Ph.D., University of Virginia, 1994


Kwak, Minyoung, Norma E. Farrow, April K. S. Salama, Paul J. Mosca, Brent A. Hanks, Craig L. Slingluff, and Georgia M. Beasley. “Updates in adjuvant systemic therapy for melanoma.” J Surg Oncol 119, no. 2 (January 2019): 222–31.

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Adair, Kathryn C., Krystina Quow, Allan Frankel, Paul J. Mosca, Jochen Profit, Allison Hadley, Michael Leonard, and J. Bryan Sexton. “The Improvement Readiness scale of the SCORE survey: a metric to assess capacity for quality improvement in healthcare.” Bmc Health Serv Res 18, no. 1 (December 17, 2018): 975.

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Masoud, Sabran J., Jennifer A. Perone, Norma E. Farrow, Paul J. Mosca, Douglas S. Tyler, and Georgia M. Beasley. “Sentinel Lymph Node Biopsy and Completion Lymph Node Dissection for Melanoma.” Curr Treat Options Oncol 19, no. 11 (September 19, 2018): 55.

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Puza, Charles J., and Paul J. Mosca. “Examining the incidence and presentation of melanoma in thoracic transplant patients.” In Journal of the American Academy of Dermatology, 79:AB138–AB138. MOSBY-ELSEVIER, 2018.


Puza, Charles J., and Paul J. Mosca. “Incidence and presentation of squamous cell carcinoma in renal transplant patients after rejection episodes.” In Journal of the American Academy of Dermatology, 79:AB165–AB165. MOSBY-ELSEVIER, 2018.


Puza, Charles J., Srirama Josyula, Alicia M. Terando, John H. Howard, Doreen M. Agnese, Paul J. Mosca, Walter T. Lee, and Georgia M. Beasley. “Does the number of sentinel lymph nodes removed affect the false negative rate for head and neck melanoma?” J Surg Oncol 117, no. 7 (June 2018): 1584–88.

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