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Paul Joseph Mosca, MD, PhD, MBA

Associate Professor of Surgery
Office: 10 Bryan Searle Drive, 466G Seeley G. Mudd Bldg, Durham, NC 27710
Campus Mail: DUMC 3966, 10 Bryan Searle Dr, 466G Seeley G Mudd, Durham, NC 27710

My research focuses on three areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy. A third area of interest is quality and patient safety with an emphasis on communication and work culture.

Education and Training

  • Assistant Professor, Surgery, Lehigh Valley Health Network, 2004 - 2010
  • Assistant Professor, Surgery, Duke University School of Medicine, 2002 - 2004
  • Chief Resident, Surgery, Duke University, 2001 - 2002
  • 2nd Year SAR, Surgery, Duke University, 2000 - 2001
  • Surgical Research Fellow, Surgery, Duke University, 1998 - 2000
  • Senior Assistant Resident, Surgery, Duke University, 1997 - 1998
  • Junior Assistant Resident, Surgery, Duke University, 1996 - 1997
  • Intern, Surgery, Duke University, 1995 - 1996
  • M.B.A., Desales University, 2011
  • M.D., University of Virginia, 1995
  • Ph.D., University of Virginia, 1994

Publications

Berger, Miles, Jeffrey N. Browndyke, Mary Cooter Wright, Chloe Nobuhara, Melody Reese, Leah Acker, W Michael Bullock, et al. “Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.” Ann Clin Transl Neurol 9, no. 2 (February 2022): 155–70. https://doi.org/10.1002/acn3.51499.

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Rodriguez-Homs, Larissa G., Sabran J. Masoud, Matthew J. Mosca, Oliver K. Jawitz, Cara O’Brien, and Paul J. Mosca. “Greater Compliance With Early Sepsis Management is Associated With Safer Care and Shorter Hospital Stay.” J Healthc Qual 43, no. 6 (November 2021): 347–54. https://doi.org/10.1097/JHQ.0000000000000295.

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Farrow, Norma E., Eda K. Holl, Jeanne Jung, Junheng Gao, Sin-Ho Jung, Rami N. Al-Rohil, Maria A. Selim, et al. “Characterization of Sentinel Lymph Node Immune Signatures and Implications for Risk Stratification for Adjuvant Therapy in Melanoma.” Ann Surg Oncol 28, no. 7 (July 2021): 3501–10. https://doi.org/10.1245/s10434-020-09277-w.

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Salama, April K. S., Manisha Palta, Christel N. Rushing, M Angelica Selim, Kristen N. Linney, Brian G. Czito, David S. Yoo, et al. “Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.” Clin Cancer Res 27, no. 5 (March 1, 2021): 1287–95. https://doi.org/10.1158/1078-0432.CCR-20-2452.

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Mosca, P. J., S. Zani, M. M. Haglund, B. H. Collins, S. Wasiolek, T. N. Pappas, A. D. Kirk, and L. C. Cendales. “The Legacy of Joseph A. Moylan, M.D.: "it's about Everyone Else".” Annals of Surgery, January 1, 2021. https://doi.org/10.1097/AS9.0000000000000051.

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Carr, Michael J., James Sun, Hidde M. Kroon, John T. Miura, Georgia M. Beasley, Norma E. Farrow, Paul J. Mosca, et al. “Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia.” Ann Surg Oncol 27, no. 13 (December 2020): 5107–18. https://doi.org/10.1245/s10434-020-09051-y.

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Rodriguez-Homs, Larissa G., Bradley G. Hammill, Marc D. Ryser, Harry R. Phillips, and Paul J. Mosca. “Relationship Between HCAHPS Scores and Survey Response Rate Is Linked to Hospital Size.” J Patient Exp 7, no. 6 (December 2020): 1543–48. https://doi.org/10.1177/2374373520932458.

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Ravichandran, Surya, Neel Nath, David C. Jones, Gabriel Li, Visakha Suresh, Adam K. Brys, Brent A. Hanks, et al. “The utility of initial staging PET-CT as a baseline scan for surveillance imaging in stage II and III melanoma.” Surg Oncol 35 (December 2020): 533–39. https://doi.org/10.1016/j.suronc.2020.10.018.

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