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Paul Joseph Mosca, MD, PhD, MBA

Associate Professor of Surgery
Division: 
Surgical Oncology
Section: 
Melanoma Surgery
Program: 
Complex General Surgical Oncology Fellowship
Duke Surgical Technique and Review (STAR) Course
General Surgery Residency Program
Office: 10 Bryan Searle Drive, 466G Seeley G. Mudd Bldg, Durham, NC 27710
Campus Mail: DUMC 3966, 10 Bryan Searle Dr, 466G Seeley G Mudd, Durham, NC 27710

My research focuses on three areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy. A third area of interest is quality and patient safety with an emphasis on communication and work culture.

Education and Training

  • Assistant Professor, Surgery, Lehigh Valley Health Network, 2004 - 2010
  • Assistant Professor, Surgery, Duke University School of Medicine, 2002 - 2004
  • Chief Resident, Surgery, Duke University, 2001 - 2002
  • 2nd Year SAR, Surgery, Duke University, 2000 - 2001
  • Surgical Research Fellow, Surgery, Duke University, 1998 - 2000
  • Senior Assistant Resident, Surgery, Duke University, 1997 - 1998
  • Junior Assistant Resident, Surgery, Duke University, 1996 - 1997
  • Intern, Surgery, Duke University, 1995 - 1996
  • M.B.A., Desales University, 2011
  • M.D., University of Virginia, 1995
  • Ph.D., University of Virginia, 1994

Selected Grants

Publications

Carr, Michael J., James Sun, Hidde M. Kroon, John T. Miura, Georgia M. Beasley, Norma E. Farrow, Paul J. Mosca, et al. “Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia.” Ann Surg Oncol 27, no. 13 (December 2020): 5107–18. https://doi.org/10.1245/s10434-020-09051-y.

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Farrow, Norma E., Eda K. Holl, Jeanne Jung, Junheng Gao, Sin-Ho Jung, Rami N. Al-Rohil, Maria A. Selim, et al. “Characterization of Sentinel Lymph Node Immune Signatures and Implications for Risk Stratification for Adjuvant Therapy in Melanoma.” Ann Surg Oncol, November 17, 2020. https://doi.org/10.1245/s10434-020-09277-w.

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Salama, April K. S., Manisha Palta, Christel N. Rushing, M Angelica Selim, Kristen N. Linney, Brian G. Czito, David S. Yoo, et al. “Ipilimumab and Radiation in Patients with High Risk Resected or Regionally Advanced Melanoma.” Clin Cancer Res, November 10, 2020. https://doi.org/10.1158/1078-0432.CCR-20-2452.

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Ravichandran, Surya, Neel Nath, David C. Jones, Gabriel Li, Visakha Suresh, Adam K. Brys, Brent A. Hanks, et al. “The utility of initial staging PET-CT as a baseline scan for surveillance imaging in stage II and III melanoma.” Surg Oncol 35 (November 2, 2020): 533–39. https://doi.org/10.1016/j.suronc.2020.10.018.

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Kenyon-Smith, Timothy J., Hidde M. Kroon, John T. Miura, Jüri Teras, Georgia M. Beasley, Dean Mullen, Norma E. Farrow, et al. “Factors predicting toxicity and response following isolated limb infusion for melanoma: An international multi-centre study.” In Eur J Surg Oncol, 46:2140–46, 2020. https://doi.org/10.1016/j.ejso.2020.06.040.

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Hu, Janice, Sabran J. Masoud, Surya Ravichandran, Georgia M. Beasley, and Paul J. Mosca. “Retreatment with talimogene laherparepvec for advanced melanoma.” Immunotherapy 12, no. 16 (November 2020): 1167–72. https://doi.org/10.2217/imt-2020-0029.

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Hu, Janice B., Surya Ravichandran, Christel Rushing, Georgia M. Beasley, Brent A. Hanks, Sin-Ho Jung, April K. S. Salama, Lisa Ho, and Paul J. Mosca. “Higher BMI, But Not Sarcopenia, Is Associated With Pembrolizumab-related Toxicity in Patients With Advanced Melanoma.” Anticancer Res 40, no. 9 (September 2020): 5245–54. https://doi.org/10.21873/anticanres.14528.

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Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.

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Adair, Kathryn C., Larissa G. Rodriguez-Homs, Sabran Masoud, Paul J. Mosca, and J Bryan Sexton. “Gratitude at Work: Prospective Cohort Study of a Web-Based, Single-Exposure Well-Being Intervention for Health Care Workers.” J Med Internet Res 22, no. 5 (May 14, 2020): e15562. https://doi.org/10.2196/15562.

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Teras, Jüri, Hidde M. Kroon, John T. Miura, Tim Kenyon-Smith, Georgia M. Beasley, Dean Mullen, Norma E. Farrow, et al. “International Multicenter Experience of Isolated Limb Infusion for In-Transit Melanoma Metastases in Octogenarian and Nonagenarian Patients.” Ann Surg Oncol 27, no. 5 (May 2020): 1420–29. https://doi.org/10.1245/s10434-020-08312-0.

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