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Herbert Kim Lyerly, MD

George Barth Geller Distinguished Professor of Immunology
Professor of Surgery
Professor in Immunology
Professor of Pathology
Office: 203 Research Drive, Rm 433B, Box 2606, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Education and Training

  • M.D., University of California - Los Angeles, 1983

Selected Grants

Publications

Zhou, Xinna, Guoliang Qiao, Xiaoli Wang, Qingkun Song, Michael A. Morse, Amy Hobeika, William R. Gwin, Jun Ren, and H Kim Lyerly. “CYP1A1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine.” Cancer Chemother Pharmacol 81, no. 2 (February 2018): 365–72. https://doi.org/10.1007/s00280-017-3500-9.

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Stilwell, Jackie L., Amy Hobeida, Ryan T. Birse, Nolan Ericson, Arturo B. Ramirez, Sara Hummel, Darryl Irwin, Eric P. Kaldjian, and H Kim Lyerly. “Detection of mutations in single tumor cells collected by fine needle aspiration in a mouse xenograft breast cancer model using MALDI-TOF.” In Cancer Research, Vol. 78. AMER ASSOC CANCER RESEARCH, 2018.

Scholars@Duke

Song, Qingkun, Jun Ren, Xinna Zhou, Xiaoli Wang, Guohong Song, Amy Hobeika, Yanhua Yuan, and Herbert Kim Lyerly. “Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study.” Cytotherapy 20, no. 1 (January 2018): 126–33. https://doi.org/10.1016/j.jcyt.2017.08.018.

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Crosby, Erika J., Junping Wei, Xiao Yi Yang, Gangjun Lei, Tao Wang, Cong-Xiao Liu, Pankaj Agarwal, et al. “Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors.” Oncoimmunology 7, no. 5 (2018): e1421891. https://doi.org/10.1080/2162402X.2017.1421891.

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Osada, Takuya, Kensuke Kaneko, William R. Gwin, Michael A. Morse, Amy Hobeika, Brian W. Pogue, Zachary C. Hartman, Philip F. Hughes, Timothy Haystead, and H Kim Lyerly. “In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior.” Clin Cancer Res 23, no. 24 (December 15, 2017): 7531–42. https://doi.org/10.1158/1078-0432.CCR-17-1453.

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Shuptrine, Casey W., Reham Ajina, Elana J. Fertig, Sandra A. Jablonski, H. Kim Lyerly, Zachary C. Hartman, and Louis M. Weiner. “An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection.” Cancer Immunol Immunother 66, no. 12 (December 2017): 1529–44. https://doi.org/10.1007/s00262-017-2047-2.

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Jiang, Ni, Guoliang Qiao, Xiaoli Wang, Michael A. Morse, William R. Gwin, Lei Zhou, Yuguang Song, et al. “Dendritic Cell/Cytokine-Induced Killer Cell Immunotherapy Combined with S-1 in Patients with Advanced Pancreatic Cancer: A Prospective Study.” Clin Cancer Res 23, no. 17 (September 1, 2017): 5066–73. https://doi.org/10.1158/1078-0432.CCR-17-0492.

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Osada, Takuya, Kensuke Kaneko, Zachary Hartman, Amy Hobeika, Philip Hughes, Timothy Haystead, Michael Morse, and H Kim Lyerly. “Abstract 1859: Hsp90 targeted near infrared molecular imaging to detect mammografically occult invasive lobular breast cancer.” In Tumor Biology. American Association for Cancer Research, 2017. https://doi.org/10.1158/1538-7445.am2017-1859.

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Kaneko, Kensuke, Takuya Osada, Timothy A. Haystead, Michael A. Morse, and Herbert K. Lyerly. “Abstract 4709: Induction of enhanced tumor-specific immunity by Hsp90 targeted photodynamic therapy (Hsp90-PDT) combined with immune checkpoint inhibition.” In Immunology. American Association for Cancer Research, 2017. https://doi.org/10.1158/1538-7445.am2017-4709.

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Snyder, Joshua C., Lauren K. Rochelle, Caroline Ray, Thomas F. Pack, Cheryl B. Bock, Veronica Lubkov, H Kim Lyerly, Alan S. Waggoner, Larry S. Barak, and Marc G. Caron. “Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.” J Biol Chem 292, no. 17 (April 28, 2017): 7208–22. https://doi.org/10.1074/jbc.M116.756635.

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