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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Dai, Qunsheng, Jianhua Huang, Bruce Klitzman, Chunming Dong, Pascal J. Goldschmidt-Clermont, Keith L. March, Joseph Rokovich, et al. “Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.” Circulation 110, no. 16 (October 19, 2004): 2467–75. https://doi.org/10.1161/01.CIR.0000145139.53840.49.

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Erdmann, Detlev, Anne M. Pippen, Kenneth J. Moquin, Ranya Sweis, Laura E. Niklason, L Scott Levin, Kevin C. Olbrich, and Bruce Klitzman. “Immunohistochemical identification of vascular endothelial growth factor in pig latissimus dorsi musculocutaneous flaps following ischemia-reperfusion injury.” Ann Plast Surg 53, no. 4 (October 2004): 398–403. https://doi.org/10.1097/01.sap.0000125503.69220.69.

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Erdmann, D., C. Heitmann, K. C. M. Pu, K. Olbrich, L. S. Levin, and B. Klitzman. “Anastomoses for vascular shunt, arterial graft, and flap vascularization performed using magnets.” In Journal of the American College of Surgeons, 199:S64–S64. ELSEVIER SCIENCE INC, 2004.

Scholars@Duke

Erdmann, Detlev, Ranya Sweis, Christoph Heitmann, Koji Yasui, Kevin C. Olbrich, L Scott Levin, A Adam Sharkawy, and Bruce Klitzman. “Side-to-side sutureless vascular anastomosis with magnets.” J Vasc Surg 40, no. 3 (September 2004): 505–11. https://doi.org/10.1016/j.jvs.2004.05.026.

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Schoenfisch, M. H., B. J. Nablo, M. E. Robbins, R. D. Butler, and B. Klitzman. “Nitric oxide release as a means for improving the tissue-compatibility of in vivo subcutaneous glucose biosensors.” In Abstracts of Papers of the American Chemical Society, 228:U159–60. AMER CHEMICAL SOC, 2004.

Scholars@Duke

Wong, Michael S., Detlev Erdmann, Ranya Sweis, Christiane Pöllmann, Margaret Farrar, Gregory S. Georgiade, L Scott Levin, Kevin C. Olbrich, and Bruce Klitzman. “Basic fibroblast growth factor expression following surgical delay of rat transverse rectus abdominis myocutaneous flaps.” Plast Reconstr Surg 113, no. 7 (June 2004): 2030–36. https://doi.org/10.1097/01.prs.0000122217.16985.52.

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Dai, Q. S., J. H. Huang, B. Klitzman, J. Rokovich, E. Rebar, B. Johnstone, C. Kontos, and B. Annex. “A genetically engineered plasmid encoding a zinc finger VEGF-activating transcription factor induces angiogenesis in the rabbits with hind-limb ischemia.” In Molecular Therapy, 7:S330–31. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2003.

Scholars@Duke

Lockhart, A Craig, Rod D. Braun, Daohai Yu, Joel R. Ross, Mark W. Dewhirst, Jeffrey S. Humphrey, Seth Thompson, et al. “Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor.” Clin Cancer Res 9, no. 2 (February 2003): 586–93.

Scholars@Duke

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