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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Rosenblum, Joshua M., and Allan D. Kirk. “Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy..” Immunol Rev 258, no. 1 (March 2014): 167–82. https://doi.org/10.1111/imr.12155.

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Xu, H., S. D. Perez, J. Cheeseman, A. K. Mehta, and A. D. Kirk. “The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation..” Am J Transplant 14, no. 2 (February 2014): 319–32. https://doi.org/10.1111/ajt.12574.

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Kim, E. J., J. Kwun, A. C. Gibby, J. J. Hong, A. B. Farris, N. N. Iwakoshi, F. Villinger, A. D. Kirk, and S. J. Knechtle. “Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection..” Am J Transplant 14, no. 1 (January 2014): 59–69. https://doi.org/10.1111/ajt.12526.

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Lo, D. J., A. B. Farris, M. Song, F. Leopardi, D. J. Anderson, E. A. Strobert, S. Ramakrishnan, et al. “Inhibition of αvβ6 promotes acute renal allograft rejection in nonhuman primates..” Am J Transplant 13, no. 12 (December 2013): 3085–93. https://doi.org/10.1111/ajt.12467.

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Koura, Divya T., John T. Horan, Amelia A. Langston, Muna Qayed, Aneesh Mehta, Hanna J. Khoury, R Donald Harvey, et al. “In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial..” Biol Blood Marrow Transplant 19, no. 11 (November 2013): 1638–49. https://doi.org/10.1016/j.bbmt.2013.09.003.

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Pena, Juan A., Lauren Titus, Jennifer Jackson, Allan D. Kirk, and Jennifer L. Gooch. “Differential regulation of calcineurin isoforms in transplant patients: a new look at an old problem..” Transplantation 96, no. 3 (August 15, 2013): 239–44. https://doi.org/10.1097/TP.0b013e31829acb64.

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O’Leary, J. G., H. M. Gebel, R. Ruiz, R. A. Bray, J. D. Marr, X. J. Zhou, S. M. Shiller, B. M. Susskind, A. D. Kirk, and G. B. Klintmalm. “Class II alloantibody and mortality in simultaneous liver-kidney transplantation..” Am J Transplant 13, no. 4 (April 2013): 954–60. https://doi.org/10.1111/ajt.12147.

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Lowe, M. C., I. R. Badell, A. P. Turner, P. W. Thompson, F. V. Leopardi, E. A. Strobert, C. P. Larsen, and A. D. Kirk. “Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy..” Am J Transplant 13, no. 2 (February 2013): 312–19. https://doi.org/10.1111/j.1600-6143.2012.04341.x.

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