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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Ma, Jun, Jasmin Divers, Nicholette D. Palmer, Bruce A. Julian, Ajay K. Israni, David Schladt, Stephen O. Pastan, et al. “Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.” Kidney Int 88, no. 3 (September 2015): 584–92.

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Forsberg, Jonathan A., Benjamin K. Potter, Matthew B. Wagner, Andrew Vickers, Christopher J. Dente, Allan D. Kirk, and Eric A. Elster. “Lessons of War: Turning Data Into Decisions.” Ebiomedicine 2, no. 9 (September 2015): 1235–42.

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Freitas, A. M., K. P. Samy, A. B. Farris, F. V. Leopardi, M. Song, L. Stempora, E. A. Strobert, J. A. Jenkins, A. D. Kirk, and L. C. Cendales. “Studies Introducing Costimulation Blockade for Vascularized Composite Allografts in Nonhuman Primates.” Am J Transplant 15, no. 8 (August 2015): 2240–49.

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Cendales, L., R. Bray, H. Gebel, L. Brewster, R. Elbein, D. Farthing, M. Song, et al. “Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report.” Am J Transplant 15, no. 8 (August 2015): 2250–55.

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Suessmuth, Y., R. Mukherjee, B. Watkins, D. T. Koura, K. Finstermeier, C. Desmarais, L. Stempora, et al. “CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRbeta repertoire.” Blood 125 (June 18, 2015): 3835–50.


Suessmuth, Yvonne, Rithun Mukherjee, Benjamin Watkins, Divya T. Koura, Knut Finstermeier, Cindy Desmarais, Linda Stempora, et al. “CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire.” Blood 125, no. 25 (June 18, 2015): 3835–50.

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Mou, Danny, Jaclyn E. Espinosa, Linda Stempora, Neal N. Iwakoshi, and Allan D. Kirk. “Viral-induced CD28 loss evokes costimulation independent alloimmunity.” J Surg Res 196, no. 2 (June 15, 2015): 241–46.

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Freedman, B. I., B. A. Julian, S. O. Pastan, A. K. Israni, D. Schladt, M. D. Gautreaux, V. Hauptfeld, et al. “Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure.” Am J Transplant 15, no. 6 (June 2015): 1615–22.

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Beasley, Georgia M., Theodore N. Pappas, and Allan D. Kirk. “Procedure Delegation by Attending Surgeons Performing Concurrent Operations in Academic Medical Centers: Balancing Safety and Efficiency.” Ann Surg 261, no. 6 (June 2015): 1044–45.

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Martin, B. M., K. P. Samy, M. C. Lowe, P. W. Thompson, J. Cano, A. B. Farris, M. Song, et al. “Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction.” American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 5 (May 2015): 1241–52.

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