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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Charafeddine, AH, Kim, EJ, Maynard, DM, Yi, H, Weaver, TA, Gunay-Aygun, M, Russell, M, Gahl, WA, and Kirk, AD. "Platelet-Derived CD154: Ultrastructural Localization and Clinical Correlation in Organ Transplantation." American Journal of Transplantation 12, no. 11 (November 2012): 3143-3151.

Full Text

Gupta, NA, Kolachala, VL, Jiang, R, Abramowsky, C, Romero, R, Fifadara, N, Anania, F, Knechtle, S, and Kirk, A. "The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis." The American journal of pathology 181, no. 5 (November 2012): 1693-1701.

Full Text

Kwun, J, Oh, BC, Gibby, AC, Ruhil, R, Lu, VT, Kim, DW, Page, EK, Bulut, OP, Song, MQ, Farris, AB, Kirk, AD, Knechtle, SJ, and Iwakoshi, NN. "Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 12, no. 10 (October 2012): 2641-2651.

Full Text

Best, V, Knechtle, SJ, Kirk, AD, and Grakoui, A. "Potential role for intrahepatic CD34+cells in immunity to hepatitis C virus." October 2012.

Scholars@Duke

Lowe, M, Badell, IR, Thompson, P, Martin, B, Leopardi, F, Strobert, E, Price, AA, Abdulkerim, HS, Wang, R, Iwakoshi, NN, Adams, AB, Kirk, AD, Larsen, CP, and Reimann, KA. "A Novel Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival." American Journal of Transplantation 12, no. 8 (August 2012): 2079-2087.

Full Text

Thompson, P, Badell, IR, Lowe, M, Turner, A, Cano, J, Avila, J, Azimzadeh, A, Cheng, X, Pierson III, RN, Johnson, B, Robertson, J, Song, M, Leopardi, F, Strobert, E, Korbutt, G, Rayat, G, Rajotte, R, Larsen, CP, and Kirk, AD. "Alternative Immunomodulatory Strategies for Xenotransplantation: CD40/154 Pathway-Sparing Regimens Promote Xenograft Survival." American Journal of Transplantation 12, no. 7 (July 2012): 1765-1775.

Full Text

Badell, IR, Russell, MC, Cardona, K, Shaffer, VO, Turner, AP, Avila, JG, Cano, JA, Leopardi, FV, Song, M, Strobert, EA, Ford, ML, Pearson, TC, Kirk, AD, and Larsen, CP. "CTLA4Ig Prevents Alloantibody Formation Following Nonhuman Primate Islet Transplantation Using the CD40-Specific Antibody 3A8." American Journal of Transplantation 12, no. 7 (July 2012): 1918-1923.

Full Text

Ramakrishnan, SK, Page, A, Farris, AB, Singh, K, Leopardi, F, Hamby, K, Sen, S, Polnett, A, Deane, T, Song, M, Stempora, L, Strobert, E, Kirk, AD, Larsen, CP, and Kean, LS. "Evidence for Kidney Rejection After Combined Bone Marrow and Renal Transplantation Despite Ongoing Whole-Blood Chimerism in Rhesus Macaques." American Journal of Transplantation 12, no. 7 (July 2012): 1755-1764.

Full Text

Singh, K, Kozyr, N, Stempora, L, Kirk, AD, Larsen, CP, Blazar, BR, and Kean, LS. "Regulatory T Cells Exhibit Decreased Proliferation but Enhanced Suppression After Pulsing With Sirolimus." American Journal of Transplantation 12, no. 6 (June 2012): 1441-1457.

Full Text

Freitas, AM, Farris, AB, Leopardi, F, Song, M, Strobert, E, Kirk, AD, and Cendales, LC. "Costimulation Blockade Based Regimens Prolong Graft Survival of Vascularized Composite Allografts in Non-Human Primates." May 2012.

Scholars@Duke

Pages