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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Freedman, B. I., B. A. Julian, S. O. Pastan, A. K. Israni, D. Schladt, M. D. Gautreaux, V. Hauptfeld, et al. “Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure.” Am J Transplant 15, no. 6 (June 2015): 1615–22. https://doi.org/10.1111/ajt.13223.

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Beasley, Georgia M., Theodore N. Pappas, and Allan D. Kirk. “Procedure Delegation by Attending Surgeons Performing Concurrent Operations in Academic Medical Centers: Balancing Safety and Efficiency.” Ann Surg 261, no. 6 (June 2015): 1044–45. https://doi.org/10.1097/SLA.0000000000001208.

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Martin, B. M., K. P. Samy, M. C. Lowe, P. W. Thompson, J. Cano, A. B. Farris, M. Song, et al. “Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction.” American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 5 (May 2015): 1241–52. https://doi.org/10.1111/ajt.13098.

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Lo, D. J., D. J. Anderson, M. Song, F. Leopardi, A. B. Farris, E. Strobert, S. Chapin, B. Devens, E. Karrer, and A. D. Kirk. “A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation.” Am J Transplant 15, no. 4 (April 2015): 984–92. https://doi.org/10.1111/ajt.13100.

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Velazquez, Victoria M., Luke S. Uebelhoer, Manoj Thapa, Chris C. Ibegbu, Cynthia Courtney, Steven E. Bosinger, Joseph F. Magliocca, et al. “Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development.” Hepatology (Baltimore, Md.) 61, no. 3 (March 2015): 843–56. https://doi.org/10.1002/hep.27575.

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Bray, R. A., P. Brannon, C. Breitenbach, C. Bryan, D. -. F. Chen, J. Lai, T. McRacken, et al. “The new OPTN kidney allocation policy: potential for inequitable access among highly sensitized patients.” Am J Transplant, January 2015. https://doi.org/10.1111/ajt.13061.

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Gupta, Nitika A., Vasantha L. Kolachala, Rong Jiang, Carlos Abramowsky, Asha Shenoi, Astrid Kosters, Haritha Pavuluri, Frank Anania, and Allan D. Kirk. “Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver.” Am J Physiol Gastrointest Liver Physiol 307, no. 11 (December 1, 2014): G1088–99. https://doi.org/10.1152/ajpgi.00210.2014.

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Singh, K., L. Stempora, R. D. Harvey, A. D. Kirk, C. P. Larsen, B. R. Blazar, and L. S. Kean. “Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.” Am J Transplant 14, no. 12 (December 2014): 2691–2703. https://doi.org/10.1111/ajt.12934.

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