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Immune Management Laboratory

Photo of Allan Douglas Kirk, MD, PhD

Allan Douglas Kirk, MD, PhD

Office: HAFS Building, 7th Floor, Suite 7690
Campus Mail: DUMC 3704, Durham, NC 27710

Scientific Focus

When patients receive an organ transplant, they must take immunosuppressive medications for life to prevent rejection. These drugs are incompletely effective and cause significant morbidity. My research is directed toward understanding transplant rejection and translating this understanding into less morbid therapies for transplant recipients.

Our group uses in vitro and animal models to develop transplant strategies and then investigates them in clinical trials. We also receive samples from patients in clinical trials to help understand what the next questions should be. We have successfully targeted several costimulatory molecules with monoclonal antibodies in primates and in humans, and are currently working to determine the best means of using these molecules to prevent kidney transplant rejection.

I am interested in the expression of CD154 on platelets and its implications for immune activation and thrombosis. I have initiated several clinical trials using monoclonal or polyclonal antibodies to achieve transient lymphocyte depletion, substantially reducing the need for immunosuppression in humans. Our group has shown that monocytes and memory T cells play a key role in post-depletional immune responses, and we are evaluating the signals influencing human monocyte and memory T cell function during depletion in humans.

Improved therapeutics and more precise monitoring techniques will facilitate tailor-made immune therapies and improve patient outcomes.

Latest Publications

Breslin, Adam W., Alexander T. Limkakeng, Elizabeth Silvius, Catherine A. Staton, Chandra Almond, Mary-Beth Joshi, Bartley Adams, et al. “Immune response profiling in patients with traumatic injuries associated with alcohol ingestion.” Clin Transl Sci 14, no. 5 (September 2021): 1791–98. https://doi.org/10.1111/cts.13022.

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Xu, He, Hui-Jie Lee, Robin Schmitz, Brian I. Shaw, Shu Li, and Allan D. Kirk. “Age-related effects on thymic output and homeostatic T cell expansion following depletional induction in renal transplant recipients.” Am J Transplant 21, no. 9 (September 2021): 3163–74. https://doi.org/10.1111/ajt.16625.

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Shaw, Brian I., Robin Schmitz, Walter J. Flores, Diogo M. Magnani, Jie Li, Mingqing Song, and Allan D. Kirk. “A comparative study of human-and rhesus-specific antithymocyte globulins in Rhesus macaques.” Clin Transplant 35, no. 8 (August 2021): e14369. https://doi.org/10.1111/ctr.14369.

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Vicente, Diego, Seth A. Schobel, Simone Anfossi, Hannah Hensman, Felipe Lisboa, Henry Robertson, Vivek Khatri, et al. “Viral Micro-RNAs Are Detected in the Early Systemic Response to Injury and Are Associated With Outcomes in Polytrauma Patients.” Crit Care Med, July 2, 2021. https://doi.org/10.1097/CCM.0000000000005181.

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