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Immune Management Laboratory

Photo of Allan Douglas Kirk, MD, PhD

Allan Douglas Kirk, MD, PhD

Office: HAFS Building, 7th Floor, Suite 7690
Campus Mail: DUMC 3704, Durham, NC 27710

Scientific Focus

When patients receive an organ transplant, they must take immunosuppressive medications for life to prevent rejection. These drugs are incompletely effective and cause significant morbidity. My research is directed toward understanding transplant rejection and translating this understanding into less morbid therapies for transplant recipients.

Our group uses in vitro and animal models to develop transplant strategies and then investigates them in clinical trials. We also receive samples from patients in clinical trials to help understand what the next questions should be. We have successfully targeted several costimulatory molecules with monoclonal antibodies in primates and in humans, and are currently working to determine the best means of using these molecules to prevent kidney transplant rejection.

I am interested in the expression of CD154 on platelets and its implications for immune activation and thrombosis. I have initiated several clinical trials using monoclonal or polyclonal antibodies to achieve transient lymphocyte depletion, substantially reducing the need for immunosuppression in humans. Our group has shown that monocytes and memory T cells play a key role in post-depletional immune responses, and we are evaluating the signals influencing human monocyte and memory T cell function during depletion in humans.

Improved therapeutics and more precise monitoring techniques will facilitate tailor-made immune therapies and improve patient outcomes.

Latest Publications

Klintmalm, GB, Kaplan, B, and Kirk, AD. "FDA jeopardizes the lives of lung transplant recipients and in the process severely increases the cost to develop new immunosuppression." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 19, no. 4 (April 2019): 971-972.

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Mulvihill, MS, Samy, KP, Gao, QA, Schmitz, R, Davis, RP, Ezekian, B, Leopardi, F, Song, M, How, T, Williams, K, Barbas, A, Collins, B, and Kirk, AD. "Secondary Lymphoid Tissue and Costimulation-Blockade Resistant Rejection: A Nonhuman Primate Renal Transplant Study." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons (March 20, 2019).

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Lin, L, Xu, H, Bishawi, M, Feng, F, Samy, K, Truskey, G, Barbas, AS, Kirk, AD, and Brennan, TV. "Circulating mitochondria in organ donors promote allograft rejection." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons (February 14, 2019).

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Shaw, BI, and Kirk, AD. "Kidney Xenotransplantation: Steps toward Clinical Application." Clinical Journal of the American Society of Nephrology : Cjasn (February 6, 2019).

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