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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Anderson, D. J., D. J. Lo, F. Leopardi, M. Song, N. A. Turgeon, E. A. Strobert, J. B. Jenkins, et al. “Anti-Leukocyte Function-Associated Antigen 1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade-Resistant Rejection.” Am J Transplant 16, no. 5 (May 2016): 1456–64. https://doi.org/10.1111/ajt.13628.

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Espinosa, J., F. Herr, G. Tharp, S. Bosinger, M. Song, A. B. Farris, R. George, et al. “CD57(+) CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection.” Am J Transplant 16, no. 4 (April 2016): 1102–12. https://doi.org/10.1111/ajt.13613.

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Xu, H., K. P. Samy, A. Guasch, S. I. Mead, A. Ghali, A. Mehta, L. Stempora, and A. D. Kirk. “Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients.” Am J Transplant 16, no. 2 (February 2016): 550–64. https://doi.org/10.1111/ajt.13469.

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Freedman, Barry I., Stephen O. Pastan, Ajay K. Israni, David Schladt, Bruce A. Julian, Michael D. Gautreaux, Vera Hauptfeld, et al. “APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors.” Transplantation 100, no. 1 (January 2016): 194–202. https://doi.org/10.1097/TP.0000000000000969.

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Dorr, Casey R., Barry I. Freedman, Pamela J. Hicks, W Mark Brown, Gregory B. Russell, Bruce A. Julian, Stephen O. Pastan, et al. “Deceased-Donor Apolipoprotein L1 Renal-Risk Variants Have Minimal Effects on Liver Transplant Outcomes.” Plos One 11, no. 4 (2016): e0152775. https://doi.org/10.1371/journal.pone.0152775.

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Cooper, David K. C., Rita Bottino, Pierre Gianello, Melanie Graham, Wayne J. Hawthorne, Allan D. Kirk, Olle Korsgren, Chung-Gyu Park, and Collin Weber. “First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial.” Xenotransplantation 23, no. 1 (January 2016): 46–52. https://doi.org/10.1111/xen.12226.

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Newell, K. A., A. Asare, I. Sanz, C. Wei, A. Rosenberg, Z. Gao, S. Kanaparthi, et al. “Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.” Am J Transplant 15, no. 11 (November 2015): 2908–20. https://doi.org/10.1111/ajt.13480.

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Elder, Robert W., Roshan P. George, Nancy M. McCabe, Fred H. Rodriguez, Wendy M. Book, William T. Mahle, and Allan D. Kirk. “Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?” Pediatric Cardiology 36, no. 7 (October 2015): 1411–16. https://doi.org/10.1007/s00246-015-1174-9.

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