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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Krummey, SM, Cheeseman, JA, Conger, JA, Jang, PS, Mehta, AK, Kirk, AD, Larsen, CP, and Ford, ML. "High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 3 (March 2014): 607-614.

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Rosenblum, JM, and Kirk, AD. "Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy." Immunological Reviews 258, no. 1 (March 2014): 167-182. (Review)

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Xu, H, Perez, SD, Cheeseman, J, Mehta, AK, and Kirk, AD. "The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 2 (February 2014): 319-332.

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Kim, EJ, Kwun, J, Gibby, AC, Hong, JJ, Farris, AB, Iwakoshi, NN, Villinger, F, Kirk, AD, and Knechtle, SJ. "Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 1 (January 2014): 59-69.

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Lo, DJ, Farris, AB, Song, M, Leopardi, F, Anderson, DJ, Strobert, EA, Ramakrishnan, S, Turgeon, NA, Mehta, AK, Turnbull, B, Maroni, B, Violette, SM, and Kirk, AD. "Inhibition of αvβ6 promotes acute renal allograft rejection in nonhuman primates." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 13, no. 12 (December 2013): 3085-3093.

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Kirk, AD. "Antilymphocyte Globulin, Monoclonal Antibodies, and Fusion Proteins." In Kidney Transplantation-Principles and Practice: Seventh Edition, 287-313. November 1, 2013.

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Sayed, BA, Kirk, AD, Pearson, TC, and Larsen, CP. "Belatacept." In Kidney Transplantation-Principles and Practice: Seventh Edition, 314-319. November 1, 2013.

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Koura, DT, Horan, JT, Langston, AA, Qayed, M, Mehta, A, Khoury, HJ, Harvey, RD, Suessmuth, Y, Couture, C, Carr, J, Grizzle, A, Johnson, HR, Cheeseman, JA, Conger, JA, Robertson, J, Stempora, L, Johnson, BE, Garrett, A, Kirk, AD, Larsen, CP, Waller, EK, and Kean, LS. "In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 19, no. 11 (November 2013): 1638-1649.

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Pena, JA, Titus, L, Jackson, J, Kirk, AD, and Gooch, JL. "Differential regulation of calcineurin isoforms in transplant patients: a new look at an old problem." Transplantation 96, no. 3 (August 2013): 239-244.

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O'Leary, JG, Gebel, HM, Ruiz, R, Bray, RA, Marr, JD, Zhou, XJ, Shiller, SM, Susskind, BM, Kirk, AD, and Klintmalm, GB. "Class II alloantibody and mortality in simultaneous liver-kidney transplantation." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 13, no. 4 (April 2013): 954-960.

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