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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Dorr, Casey R., Barry I. Freedman, Pamela J. Hicks, W Mark Brown, Gregory B. Russell, Bruce A. Julian, Stephen O. Pastan, et al. “Deceased-Donor Apolipoprotein L1 Renal-Risk Variants Have Minimal Effects on Liver Transplant Outcomes.” Plos One 11, no. 4 (2016): e0152775.

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Cooper, David K. C., Rita Bottino, Pierre Gianello, Melanie Graham, Wayne J. Hawthorne, Allan D. Kirk, Olle Korsgren, Chung-Gyu Park, and Collin Weber. “First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial.” Xenotransplantation 23, no. 1 (January 2016): 46–52.

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Newell, K. A., A. Asare, I. Sanz, C. Wei, A. Rosenberg, Z. Gao, S. Kanaparthi, et al. “Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.” Am J Transplant 15, no. 11 (November 2015): 2908–20.

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Elder, Robert W., Roshan P. George, Nancy M. McCabe, Fred H. Rodriguez, Wendy M. Book, William T. Mahle, and Allan D. Kirk. “Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?” Pediatr Cardiol 36, no. 7 (October 2015): 1411–16.

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Ma, Jun, Jasmin Divers, Nicholette D. Palmer, Bruce A. Julian, Ajay K. Israni, David Schladt, Stephen O. Pastan, et al. “Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.” Kidney Int 88, no. 3 (September 2015): 584–92.

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Forsberg, Jonathan A., Benjamin K. Potter, Matthew B. Wagner, Andrew Vickers, Christopher J. Dente, Allan D. Kirk, and Eric A. Elster. “Lessons of War: Turning Data Into Decisions.” Ebiomedicine 2, no. 9 (September 2015): 1235–42.

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Freitas, A. M., K. P. Samy, A. B. Farris, F. V. Leopardi, M. Song, L. Stempora, E. A. Strobert, J. A. Jenkins, A. D. Kirk, and L. C. Cendales. “Studies Introducing Costimulation Blockade for Vascularized Composite Allografts in Nonhuman Primates.” Am J Transplant 15, no. 8 (August 2015): 2240–49.

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Cendales, L., R. Bray, H. Gebel, L. Brewster, R. Elbein, D. Farthing, M. Song, et al. “Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report.” Am J Transplant 15, no. 8 (August 2015): 2250–55.

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Suessmuth, Y., R. Mukherjee, B. Watkins, D. T. Koura, K. Finstermeier, C. Desmarais, L. Stempora, et al. “CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRbeta repertoire.” Blood 125 (June 18, 2015): 3835–50.