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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Jerome, K. R., A. D. Kirk, G. Pecher, W. W. Ferguson, and O. J. Finn. “A survivor of breast cancer with immunity to MUC-1 mucin, and lactational mastitis..” Cancer Immunol Immunother 43, no. 6 (January 1997): 355–60.


Kirk, A. D., D. M. Heisey, A. M. D’Alessandro, S. J. Knechtle, J. S. Odorico, S. C. Rayhill, H. W. Sollinger, and J. D. Pirsch. “Clinical hepatitis after transplantation of hepatitis C virus-positive kidneys: HLA-DR3 as a risk factor for the development of posttransplant hepatitis..” Transplantation 62, no. 12 (December 27, 1996): 1758–62.


Ibrahim, S., A. D. Kirk, and F. Sanfilippo. “Phenotype of infiltrating cells in an ex vivo model of human antiporcine hyperacute cardiac xenograft rejection..” Transplant Proc 28, no. 2 (April 1996).


Rayhill, S. C., M. Heimes, A. D. Kirk, and H. W. Sollinger. “Simultaneous pancreas - kidney transplantation: Recent experience at the University of Wisconsin.” Experimental and Clinical Endocrinology and Diabetes 104, no. 5 (1996): 353–59.


Kirk, A. D., R. R. Bollinger, and O. J. Finn. “Rapid, comprehensive analysis of human cytokine mRNA and its application to the study of acute renal allograft rejection..” Hum Immunol 43, no. 2 (June 1995): 113–28.


Rayhill, S. C., A. D. Kirk, J. S. Odorico, D. M. Heisey, C. B. Cangro, J. D. Pirsch, A. M. D’Alessandro, S. J. Knechtle, and H. W. Sollinger. “Simultaneous pancreas-kidney transplantation at the University of Wisconsin..” Clin Transpl, 1995, 261–69.


Chari, R. S., B. H. Collins, J. C. Magee, J. M. DiMaio, A. D. Kirk, R. C. Harland, R. L. McCann, J. L. Platt, and W. C. Meyers. “Brief report: treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation..” N Engl J Med 331, no. 4 (July 28, 1994): 234–37.

Full Text

Pruitt, S. K., A. D. Kirk, R. R. Bollinger, H. C. Marsh, B. H. Collins, J. L. Levin, J. R. Mault, J. S. Heinle, S. Ibrahim, and A. R. Rudolph. “The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts..” Transplantation 57, no. 3 (February 1994): 363–70.


Kirk, A. D., J. S. Heinle, J. R. Mault, and F. Sanfilippo. “Ex vivo characterization of human anti-porcine hyperacute cardiac rejection..” Transplantation 56, no. 4 (October 1993): 785–93.


Ross, J. R., A. D. Kirk, S. E. Ibrahim, D. N. Howell, W. M. Baldwin, and F. P. Sanfilippo. “Characterization of human anti-porcine "natural antibodies" recovered from ex vivo perfused hearts--predominance of IgM and IgG2..” Transplantation 55, no. 5 (May 1993): 1144–50.