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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Xu, H., F. Arnaud, D. K. Tadaki, L. C. Burkly, D. M. Harlan, and A. D. Kirk. “Human platelets activate porcine endothelial cells through a CD154 dependent mechanism.” In Transplantation, 69:S384–S384. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Swanson, S. J., K. C. Abbott, J. D. Oliver, C. W. Ko, A. D. Kirk, and L. Y. Agodoa. “Impact of donor and recipient factors on graft survival after cadaveric renal transplantation: Data from the UNOS/USRDS database.” In Transplantation, 69:S262–63. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Batty, D. S., S. J. Swanson, S. M. Polly, J. D. Oliver, D. K. Oliver, C. W. Ko, A. D. Kirk, L. Y. Agodoa, and K. C. Abbott. “Impact of recipient and donor hepatitis C virus infection status on outcomes after renal transplantation: Data from the UNOS/USRDS database.” In Transplantation, 69:S135–S135. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Abbott, K. C., J. D. Oliver, C. W. Ko, A. D. Kirk, S. M. Polly, C. A. Jones, and L. Y. Agodoa. “Patient and renal allograft survival in patients seropositive for human immunodeficiency virus infection at transplantation: Data from the UNOS/USRDS database.” In Transplantation, 69:S217–S217. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Xu, H., D. K. Tadaki, P. J. Blair, D. M. Harlan, and A. D. Kirk. “Porcine endothelium costimulates human T cells in the absence of human antigen presenting cells (APCs).” In Transplantation, 69:S258–S258. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Elster, E. A., H. Xu, L. C. Burkly, J. D. Berning, R. E. Baumgartner, R. L. Kampen, N. B. Patterson, D. K. Tadaki, D. M. Harlan, and A. D. Kirk. “Primary skin allograft acceptance with anti-CD154 in a non-human primate model.” In Transplantation, 69:S239–S239. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Kirk, A. D., D. K. Tadaki, H. Xu, E. A. Elster, L. C. Burkley, A. Celniker, D. S. Batty, et al. “Primate allotransplantation using costimulation blockade.” Transplantation 69, no. 8 (April 27, 2000): S414–S414.

Scholars@Duke

Becker, B. N., L. M. Jacobson, D. A. Hullett, Y. T. Becker, T. D. Oberley, and A. D. Kirk. “Type 2 angiotensin II receptor mRNA expression in human renal allografts is associated with chronic rejection.” In Transplantation, 69:S400–S400. LIPPINCOTT WILLIAMS & WILKINS, 2000.

Scholars@Duke

Becker, B. N., L. M. Jacobson, Y. T. Becker, N. A. Radke, D. M. Heisey, T. D. Oberley, J. D. Pirsch, H. W. Sollinger, P. C. Brazy, and A. D. Kirk. “Renin-angiotensin system gene expression in post-transplant hypertension predicts allograft function.” Transplantation 69, no. 7 (April 15, 2000): 1485–91. https://doi.org/10.1097/00007890-200004150-00046.

Full Text

Burlingham, W. J., P. J. O’Connell, L. M. Jacobson, B. N. Becker, A. D. Kirk, V. Pravica, and I. V. Hutchinson. “Tumor necrosis factor-alpha and tumor growth factor-beta1 genotype: partial association with intragraft gene expression in two cases of long-term peripheral tolerance to a kidney transplant.” Transplantation 69, no. 7 (April 15, 2000): 1527–30. https://doi.org/10.1097/00007890-200004150-00058.

Full Text

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