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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Xu, H., F. Arnaud, D. K. Tadaki, L. C. Burkly, D. M. Harlan, and A. D. Kirk. “Human platelets activate porcine endothelial cells through a CD154-dependent pathway.” Transplantation 72, no. 11 (December 15, 2001): 1858–61.

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Elster, E. A., H. Xu, D. K. Tadaki, S. Montgomery, L. C. Burkly, J. D. Berning, R. E. Baumgartner, et al. “Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates.” Transplantation 72, no. 9 (November 15, 2001): 1473–78.

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Hoffmann, S. C., E. M. Stanley, E. Darrin Cox, N. Craighead, B. S. DiMercurio, D. E. Koziol, D. M. Harlan, A. D. Kirk, and P. J. Blair. “Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes.” Transplantation 72, no. 8 (October 27, 2001): 1444–50.

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Abbott, K. C., R. J. Oglesby, I. O. Hypolite, A. D. Kirk, C. W. Ko, P. G. Welch, L. Y. Agodoa, and W. E. Duncan. “Hospitalizations for fractures after renal transplantation in the United States.” Ann Epidemiol 11, no. 7 (October 2001): 450–57.

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Cox, E. D., S. C. Hoffmann, B. S. DiMercurio, R. A. Wesley, D. M. Harlan, A. D. Kirk, and P. J. Blair. “Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6.” Transplantation 72, no. 4 (August 27, 2001): 720–26.

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Cho, C. S., L. C. Burkly, J. H. Fechner, A. D. Kirk, T. D. Oberley, Y. Dong, K. G. Brunner, et al. “Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients.” Transplantation 72, no. 4 (August 27, 2001): 587–97.

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Kirk, A. D., D. K. Tadaki, A. Celniker, D. S. Batty, J. D. Berning, J. O. Colonna, F. Cruzata, et al. “Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates.” Transplantation 72, no. 3 (August 15, 2001): 377–84.

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Batty, D. S., S. J. Swanson, A. D. Kirk, C. W. Ko, L. Y. Agodoa, and K. C. Abbott. “Hepatitis C virus seropositivity at the time of renal transplantation in the United States: associated factors and patient survival.” Am J Transplant 1, no. 2 (July 2001): 179–84.


Kirk, A. D., P. J. Blair, D. K. Tadaki, H. Xu, and D. M. Harlan. “The role of CD154 in organ transplant rejection and acceptance.” Philos Trans R Soc Lond B Biol Sci 356, no. 1409 (May 29, 2001): 691–702.

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