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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Elster, E. A., P. J. Blair, and A. D. Kirk. “Potential of costimulation-based therapies for composite tissue allotransplantation..” Microsurgery 20, no. 8 (2000): 430–34. https://doi.org/10.1002/1098-2752(2000)20:8<430::aid-micr14>3.0.co;2-k.

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Elster, Eric A., Patrick J. Blair, and Allan D. Kirk. “Potential of costimulation‐based therapies for composite tissue allotransplantation.” In Microsurgery, 20:430–34. Wiley, 2000. https://doi.org/10.1002/1098-2752(2000)20:8<430::aid-micr14>3.3.co;2-b.

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Kirk, A. D., L. M. Jacobson, D. M. Heisey, N. F. Radke, J. D. Pirsch, and H. W. Sollinger. “Clinically stable human renal allografts contain histological and RNA-based findings that correlate with deteriorating graft function..” Transplantation 68, no. 10 (November 27, 1999): 1578–82. https://doi.org/10.1097/00007890-199911270-00024.

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Harlan, D. M., and A. D. Kirk. “The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection?.” Jama 282, no. 11 (September 15, 1999): 1076–82. https://doi.org/10.1001/jama.282.11.1076.

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Kenyon, N. S., M. Chatzipetrou, M. Masetti, A. Ranuncoli, M. Oliveira, J. L. Wagner, A. D. Kirk, D. M. Harlan, L. C. Burkly, and C. Ricordi. “Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154..” Proc Natl Acad Sci U S A 96, no. 14 (July 6, 1999): 8132–37. https://doi.org/10.1073/pnas.96.14.8132.

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Kenyon, N. S., L. A. Fernandez, R. Lehmann, M. Masetti, A. Ranuncoli, M. Chatzipetrou, G. Iaria, et al. “Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154..” Diabetes 48, no. 7 (July 1999): 1473–81. https://doi.org/10.2337/diabetes.48.7.1473.

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Kirk, A. D., L. C. Burkly, D. S. Batty, R. E. Baumgartner, J. D. Berning, K. Buchanan, J. H. Fechner, et al. “Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates..” Nat Med 5, no. 6 (June 1999): 686–93. https://doi.org/10.1038/9536.

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Knechtle, S. J., A. D. Kirk, J. H. Fechner, X. Hong, Y. Dong, M. M. Hamawy, and D. M. Harlan. “Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand..” Transplant Proc 31, no. 3B Suppl (May 1999): 27S-28S. https://doi.org/10.1016/s0041-1345(99)00100-1.

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Kenyon, Norma S., Maria Chatzipetrou, Michele Masetti, Alessandra Ranuncoli, Maria Oliveira, Joseph L. Wagner, Allan D. Kirk, David M. Harlan, Linda C. Burkly, and Camillo Ricordi. “LONG-TERM INTRAHEPATIC ISLET ALLOGRAFT SURVIVAL IN NON-HUMAN PRIMATES TREATED WITH ANTI-CD154 MONOTHERAPY.” In Transplantation, 67:S550–S550. Ovid Technologies (Wolters Kluwer Health), 1999. https://doi.org/10.1097/00007890-199905150-00057.

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Tadaki, Douglas K., Amanda Williams, Allan D. Kirk, Kelvin P. Lee, and David M. Harlan. “CLONING OF PORCINE CD80 AND CHARACTERIZATION OF HUMAN T CELL COSTIMULATORY ACTIVITY.” In Transplantation, 67:S222–S222. Ovid Technologies (Wolters Kluwer Health), 1999. https://doi.org/10.1097/00007890-199904150-00886.

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