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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin, Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Vanrenterghem, Yves, Kathleen Claes, Pieter Evenepoel, Dirk Kuypers, and Bart Maes. “Kidney transplantation with rabbit antithymocyte globulin and sirolimus monotherapy.” Lancet, March 15, 2003. https://doi.org/10.1016/S0140-6736(03)12752-3.

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Xu, He, Sean P. Montgomery, Edwin H. Preston, Douglas K. Tadaki, Douglas A. Hale, David M. Harlan, and Allan D. Kirk. “Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation.” J Immunol 170, no. 5 (March 1, 2003): 2776–82. https://doi.org/10.4049/jimmunol.170.5.2776.

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Hale, D. A., S. J. Swanson, R. B. Mannon, D. E. Kleiner, S. C. Hoffmann, R. L. Kampen, L. K. Cendales, D. K. Tadaki, D. M. Harlan, and A. D. Kirk. “Immunologic monitoring of the transplant recipient: Challenges and approaches with antibody induction.” Transplantation Reviews 17, no. 4 SUPPL. (January 1, 2003). https://doi.org/10.1016/j.trre.2003.07.003.

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Hirshberg, B., E. H. Preston, H. Xu, M. G. Wysoki, Z. Neeman, D. Bunnell, S. Soleimanpour, D. A. Hale, A. D. Kirk, and D. M. Harlan. “Rabbit anti-thymocyte globulin induction and sirolmius monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model.” In Cell Transplantation, 12:143–44. COGNIZANT COMMUNICATION CORP, 2003.

Scholars@Duke

Li, Rui-Mei, Roslyn B. Mannon, David Kleiner, Maria Tsokos, Michelle Bynum, Allen D. Kirk, and Jeffrey B. Kopp. “BK virus and SV40 co-infection in polyomavirus nephropathy.” Transplantation 74, no. 11 (December 15, 2002): 1497–1504. https://doi.org/10.1097/00007890-200212150-00004.

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Montgomery, Sean P., He Xu, Douglas K. Tadaki, Abbie Celniker, Linda C. Burkly, Justin D. Berning, Francis Cruzata, et al. “Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation.” Transplantation 74, no. 10 (November 27, 2002): 1365–69. https://doi.org/10.1097/00007890-200211270-00002.

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Swanson, S John, Douglas A. Hale, Roslyn B. Mannon, David E. Kleiner, Linda C. Cendales, Christine E. Chamberlain, Shirley M. Polly, David M. Harlan, and Allan D. Kirk. “Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy.” Lancet 360, no. 9346 (November 23, 2002): 1662–64. https://doi.org/10.1016/S0140-6736(02)11606-0.

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Xu, He, Douglas K. Tadaki, Eric A. Elster, Linda C. Burkly, Justin D. Berning, Francis Cruzata, Robert L. Kampen, et al. “Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates.” Transplantation 74, no. 7 (October 15, 2002): 940–43. https://doi.org/10.1097/00007890-200210150-00007.

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Hoffmann, Steven C., Robert L. Kampen, Shashi Amur, Muhammad A. Sharaf, David E. Kleiner, Keith Hunter, S. John Swanson, et al. “Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury.” Transplantation 74, no. 7 (October 15, 2002): 916–23. https://doi.org/10.1097/00007890-200210150-00003.

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Swanson, S. J., A. D. Kirk, C. W. Ko, C. A. Jones, L. Y. Agodoa, and K. C. Abbott. “Impact of HIV seropositivity on graft and patient survival after cadaveric renal transplantation in the United States in the pre highly active antiretroviral therapy (HAART) era: an historical cohort analysis of the United States Renal Data System.” Transpl Infect Dis 4, no. 3 (September 2002): 144–47. https://doi.org/10.1034/j.1399-3062.2002.01009.x.

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