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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Division: 
Abdominal Transplant Surgery
Faculty Lab: 
Immune Management Laboratory
Program: 
Abdominal Transplant Surgery Fellowship
Duke Surgical Technique and Review (STAR) Course
General Surgery Residency Program
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

In the News

Selected Grants

Publications

Daneshmand, M. A., and A. D. Kirk. “Immunosuppression in organ transplantation.” In Fischer’s Mastery of Surgery, Seventh Edition, 1:141–50, 2018.

Scholars@Duke

Espinosa, Jaclyn R., Danny Mou, Bartley W. Adams, Louis R. DiBernardo, Andrea L. MacDonald, MacKenzie McRae, Allison N. Miller, et al. “T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice.” Front Immunol 9 (2018): 1371. https://doi.org/10.3389/fimmu.2018.01371.

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Kwun, Jean, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, et al. “Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates.” Blood Adv 1, no. 24 (November 14, 2017): 2115–19. https://doi.org/10.1182/bloodadvances.2017010991.

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Adams, A. B., J. Goldstein, C. Garrett, R. Zhang, R. E. Patzer, K. A. Newell, N. A. Turgeon, et al. “Belatacept Combined With Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long-Term Renal Allograft Function.” Am J Transplant 17, no. 11 (November 2017): 2922–36. https://doi.org/10.1111/ajt.14353.

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Johnston, B. E., C. A. Quigley, S. M. Griffin, A. T. Limkakeng, M. D. Darrabie, J. A. Cheeseman, A. D. Kirk, and E. A. Elster. “313 Evaluation of Phenylalanine and Tyrosine Concentrations in Traumatically Injured Patients.” In Annals of Emergency Medicine, 70:S123–S123. Elsevier BV, 2017. https://doi.org/10.1016/j.annemergmed.2017.07.384.

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Dente, Christopher J., Matthew Bradley, Seth Schobel, Beverly Gaucher, Timothy Buchman, Allan D. Kirk, and Eric Elster. “Towards precision medicine: Accurate predictive modeling of infectious complications in combat casualties.” J Trauma Acute Care Surg 83, no. 4 (October 2017): 609–16. https://doi.org/10.1097/TA.0000000000001596.

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Ettenger, R., H. Chin, K. Kesler, N. Bridges, P. Grimm, E. F. Reed, M. Sarwal, et al. “Relationship Among Viremia/Viral Infection, Alloimmunity, and Nutritional Parameters in the First Year After Pediatric Kidney Transplantation.” Am J Transplant 17, no. 6 (June 2017): 1549–62. https://doi.org/10.1111/ajt.14169.

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Samy, K. P., D. J. Anderson, D. J. Lo, M. S. Mulvihill, M. Song, A. B. Farris, B. S. Parker, et al. “Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model.” Am J Transplant 17, no. 5 (May 2017): 1193–1203. https://doi.org/10.1111/ajt.14141.

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Belard, Arnaud, Timothy Buchman, Jonathan Forsberg, Benjamin K. Potter, Christopher J. Dente, Allan Kirk, and Eric Elster. “Precision diagnosis: a view of the clinical decision support systems (CDSS) landscape through the lens of critical care.” J Clin Monit Comput 31, no. 2 (April 2017): 261–71. https://doi.org/10.1007/s10877-016-9849-1.

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Modena, B. D., R. Milam, F. Harrison, J. A. Cheeseman, M. M. Abecassis, J. J. Friedewald, A. D. Kirk, and D. R. Salomon. “Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies.” Am J Transplant 17, no. 3 (March 2017): 712–23. https://doi.org/10.1111/ajt.14038.

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