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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Division: 
Abdominal Transplant Surgery
Faculty Lab: 
Immune Management Laboratory
Program: 
Abdominal Transplant Surgery Fellowship
General Surgery Residency Program
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

In the News

Selected Grants

Publications

Espinosa, JR, Samy, KP, and Kirk, AD. "Memory T cells in organ transplantation: progress and challenges." Nature Reviews. Nephrology 12, no. 6 (June 2016): 339-347. (Review)

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Anderson, DJ, Lo, DJ, Leopardi, F, Song, M, Turgeon, NA, Strobert, EA, Jenkins, JB, Wang, R, Reimann, KA, Larsen, CP, and Kirk, AD. "Anti-Leukocyte Function-Associated Antigen 1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade-Resistant Rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 5 (May 2016): 1456-1464.

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Espinosa, J, Herr, F, Tharp, G, Bosinger, S, Song, M, Farris, AB, George, R, Cheeseman, J, Stempora, L, Townsend, R, Durrbach, A, and Kirk, AD. "CD57(+) CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 4 (April 2016): 1102-1112.

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Xu, H, Samy, KP, Guasch, A, Mead, SI, Ghali, A, Mehta, A, Stempora, L, and Kirk, AD. "Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 2 (February 2016): 550-564.

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Freedman, BI, Pastan, SO, Israni, AK, Schladt, D, Julian, BA, Gautreaux, MD, Hauptfeld, V, Bray, RA, Gebel, HM, Kirk, AD, Gaston, RS, Rogers, J, Farney, AC, Orlando, G, Stratta, RJ, Mohan, S, Ma, L, Langefeld, CD, Bowden, DW, Hicks, PJ, Palmer, ND, Palanisamy, A, Reeves-Daniel, AM, Brown, WM, and Divers, J. "APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors." Transplantation 100, no. 1 (January 2016): 194-202.

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Dorr, CR, Freedman, BI, Hicks, PJ, Brown, WM, Russell, GB, Julian, BA, Pastan, SO, Gautreaux, MD, Muthusamy, A, Chinnakotla, S, Hauptfeld, V, Bray, RA, Kirk, AD, Divers, J, and Israni, AK. "Deceased-Donor Apolipoprotein L1 Renal-Risk Variants Have Minimal Effects on Liver Transplant Outcomes." Plos One 11, no. 4 (January 2016): e0152775-null.

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Cooper, DKC, Bottino, R, Gianello, P, Graham, M, Hawthorne, WJ, Kirk, AD, Korsgren, O, Park, C-G, and Weber, C. "First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial." Xenotransplantation 23, no. 1 (January 2016): 46-52.

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Newell, KA, Asare, A, Sanz, I, Wei, C, Rosenberg, A, Gao, Z, Kanaparthi, S, Asare, S, Lim, N, Stahly, M, Howell, M, Knechtle, S, Kirk, A, Marks, WH, Kawai, T, Spitzer, T, Tolkoff-Rubin, N, Sykes, M, Sachs, DH, Cosimi, AB, Burlingham, WJ, Phippard, D, and Turka, LA. "Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 11 (November 2015): 2908-2920.

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Elder, RW, George, RP, McCabe, NM, Rodriguez, FH, Book, WM, Mahle, WT, and Kirk, AD. "Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?." Pediatric cardiology 36, no. 7 (October 2015): 1411-1416.

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Lo, DJ, and Kirk, AD. "Immune responses to transplants." In Transplant Immunology, 142-163. September 12, 2015.

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