
I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.
Costimulation Blockade in Organ Transplantion
Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery
Education and Training
- Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
- Chief Resident, Surgery, Duke University, 1994 - 1995
- Senior Resident, Surgery, Duke University, 1992 - 1994
- Research Fellow, Surgery, Duke University, 1989 - 1992
- Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
- Ph.D., Duke University, 1992
- M.D., Duke University School of Medicine, 1987
- B.S., Old Dominion University, 1983
In the News
- What Causes a Person's Immune System to Weaken?May 20, 2020
- N.C.'s first hand transplant goes to man from TexasJune 9, 2016
- Texas man receives N.C.’s first hand transplant at DukeJune 9, 2016
- Duke Surgery Helping Wounded WarriorsDecember 3, 2015
- Duke Announces 2015 Distinguished ProfessorsMay 1, 2015
Selected Grants
- Neonatal porcine islet xenografts for the treatment of type 1 diabetes
- Basic Immunology Training Program
- Genetic approaches to skin regeneration in zebrafish
- Viela Bio Inc., VIB4920 Drug Study for Kidney Transplant Patients
- Advanced Immunobiology Traning Program for Surgeons
- Unified Program for Therapeutics in Children
- Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG)
- AX-158: Utilizing Nck Inhibition as Immunomodulation in Allotransplantation
- Duke Resident Physician-Scientist Program - NIAID
- Duke Resident Physician-Scientist Program- NHLBI
- (TEACH) Immune Tolerance Network
- TEACH Clinical Trial
- ITN056ST Optimal Co-Chair Protocol
- Determining Proliferative Potential and Factors Necessary for the Proliferation
- Examining the Depletional Profile of the Anti-CD2
- Novel Therapies to Modulate the Inflammatory Alloresponse in Renal Grafts
- The Lung Transplant Clinical Trials Network (LT-CTN)
- Nonhuman Primate Reagent Resources
- Mechanisms of Belatacept-resistant Renal Allograft Rejection
- Sc2i
- ITN Study: EP234: Real time flow cytometry at Duke for TEACH
- Immune Tolerance Network - Flow Cytometry
- American Journal of Transplantation
- Positioning Vascilarized Composite Allotramsplantation within the Spectrum of Transplantation
- Donor apoptotic cell infusion for tolerance to monkey kidney allografts
- Phase 2 Study of Belatacept, Alemtuzumab, and Sirolimus in Renal Transplantation
- Establishing a Linear Program for the Development of Co-stimulation Resistant T-cells
- T cell Receptor Diversity as a Determinant of Co-stimulation Blockade Resistance
- Interface of Mitochondrial Quality Control and Immune Activation in Heart Transplant
- SC2i
- Immunomodulation to Optimize Vascularized Composite Allograft Integration for Limb Loss Therapy
- ITN iWITH Project
- Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients
- CD57+CD4+ T cells in Belatacept-resistant Renal Allograft Rejection
- EP86: Flow Cytometry for Liver Transplant Tolerance Enhanced by Sirolimus Therapy
- The impact of Epstein Barr virus infection on the immune response in pediatric transplant recipients
- (TEACH) Atemtuzumab, Costimulation Blockade and Sirolimus: A Tolerogenic Canvas for Donor Antigen Delivery via Mesenchymal
- Role of Mitochondrial Injury in the Pathogenesis of Primary Graft Dysfunction Following Cardiac Transplantation
- T Cell Maturation and the Nexus of Viral- and Allo-Immunity
- Transplant Tolerance in Non-Human Primates
- Mouse Heart Transplant
- The Role of Rapamycin in Altering Graft Endothelial Cell Alloimmunogenicity
- Role of Mitochondrial Injury in the Pathogenesis of Primary Graft Dysfunction Following Cardiac Transplantation
- Exercise, Nitric Oxide Bioavailability and Arteriovenous Fistula Maturation
- Immune Tolerance Network - Flow Cytometry
- ASTS-Alexion Presidential Student Mentor Grant
- Development of a Composite Tissue Allotransplantation Research Program
- CD57+CD4+ T cells in Belatacept-resistant Renal Allograft Rejection
- Transplant Tolerance in Non-Human Primates