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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Division: 
Abdominal Transplant Surgery
Faculty Lab: 
Immune Management Laboratory
Program: 
Abdominal Transplant Surgery Fellowship
General Surgery Residency Program
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

In the News

Selected Grants

Publications

Newell, KA, Asare, A, Sanz, I, Wei, C, Rosenberg, A, Gao, Z, Kanaparthi, S, Asare, S, Lim, N, Stahly, M, Howell, M, Knechtle, S, Kirk, A, Marks, WH, Kawai, T, Spitzer, T, Tolkoff-Rubin, N, Sykes, M, Sachs, DH, Cosimi, AB, Burlingham, WJ, Phippard, D, and Turka, LA. "Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 11 (November 2015): 2908-2920.

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Elder, RW, George, RP, McCabe, NM, Rodriguez, FH, Book, WM, Mahle, WT, and Kirk, AD. "Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?." Pediatric cardiology 36, no. 7 (October 2015): 1411-1416.

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Lo, DJ, and Kirk, AD. "Immune responses to transplants." In Transplant Immunology, 142-163. September 12, 2015.

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Ma, J, Divers, J, Palmer, ND, Julian, BA, Israni, AK, Schladt, D, Pastan, SO, Chattrabhuti, K, Gautreaux, MD, Hauptfeld, V, Bray, RA, Kirk, AD, Brown, WM, Gaston, RS, Rogers, J, Farney, AC, Orlando, G, Stratta, RJ, Guan, M, Palanisamy, A, Reeves-Daniel, AM, Bowden, DW, Langefeld, CD, Hicks, PJ, Ma, L, and Freedman, BI. "Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation." Kidney international 88, no. 3 (September 2015): 584-592.

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Forsberg, JA, Potter, BK, Wagner, MB, Vickers, A, Dente, CJ, Kirk, AD, and Elster, EA. "Lessons of War: Turning Data Into Decisions." EBioMedicine 2, no. 9 (September 2015): 1235-1242.

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Freitas, AM, Samy, KP, Farris, AB, Leopardi, FV, Song, M, Stempora, L, Strobert, EA, Jenkins, JA, Kirk, AD, and Cendales, LC. "Studies Introducing Costimulation Blockade for Vascularized Composite Allografts in Nonhuman Primates." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 8 (August 2015): 2240-2249.

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Cendales, L, Bray, R, Gebel, H, Brewster, L, Elbein, R, Farthing, D, Song, M, Parker, D, Stillman, A, Pearson, T, and Kirk, AD. "Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 8 (August 2015): 2250-2255.

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Suessmuth, Y, Mukherjee, R, Watkins, B, Koura, DT, Finstermeier, K, Desmarais, C, Stempora, L, Horan, JT, Langston, A, Qayed, M, Khoury, HJ, Grizzle, A, Cheeseman, JA, Conger, JA, Robertson, J, Garrett, A, Kirk, AD, Waller, EK, Blazar, BR, Mehta, AK, Robins, HS, and Kean, LS. "CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRbeta repertoire." Blood 125 (June 18, 2015): 3835-3850. (Academic Article)

Scholars@Duke

Freedman, BI, Julian, BA, Pastan, SO, Israni, AK, Schladt, D, Gautreaux, MD, Hauptfeld, V, Bray, RA, Gebel, HM, Kirk, AD, Gaston, RS, Rogers, J, Farney, AC, Orlando, G, Stratta, RJ, Mohan, S, Ma, L, Langefeld, CD, Hicks, PJ, Palmer, ND, Adams, PL, Palanisamy, A, Reeves-Daniel, AM, and Divers, J. "Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 6 (June 2015): 1615-1622.

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Suessmuth, Y, Mukherjee, R, Watkins, B, Koura, DT, Finstermeier, K, Desmarais, C, Stempora, L, Horan, JT, Langston, A, Qayed, M, Khoury, HJ, Grizzle, A, Cheeseman, JA, Conger, JA, Robertson, J, Garrett, A, Kirk, AD, Waller, EK, Blazar, BR, Mehta, AK, Robins, HS, and Kean, LS. "CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire." Blood 125, no. 25 (June 2015): 3835-3850.

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