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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Zheng, HB, Watkins, B, Tkachev, V, Yu, S, Tran, D, Furlan, S, Zeleski, K, Singh, K, Hamby, K, Hotchkiss, C, Lane, J, Gumber, S, Adams, AB, Cendales, L, Kirk, AD, Kaur, A, Blazar, BR, Larsen, CP, and Kean, LS. "The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 3 (March 2017): 657-670.

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Roedder, S, Sigdel, T, Hsieh, S-C, Cheeseman, J, Metes, D, Macedo, C, Reed, EF, Gritsch, HA, Zeevi, A, Shapiro, R, Kirk, AD, and Sarwal, MM. "Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection." Frontiers in medicine 4 (January 2017): 185-.

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George, RP, Mehta, AK, Perez, SD, Winterberg, P, Cheeseman, J, Johnson, B, Kwun, J, Monday, S, Stempora, L, Warshaw, B, and Kirk, AD. "Premature T Cell Senescence in Pediatric CKD." Journal of the American Society of Nephrology : JASN 28, no. 1 (January 2017): 359-367.

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Land, WG, Agostinis, P, Gasser, S, Garg, AD, and Linkermann, A. "DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 12 (December 2016): 3322-3337. (Review)

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Klintmalm, GB, Vincenti, F, and Kirk, A. "Steroid-Responsive Acute Rejection Should Not Be the End Point for Immunosuppressive Trials." American Journal of Transplantation 16, no. 11 (November 2016): 3077-3078.

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Darrabie, MD, Lee, J, Cheeseman, J, Limkakeng, AT, Vaslef, SN, Sullenger, BA, and Kirk, AD. "Toll-Like Receptor Signaling as a Prognostic Tool in Trauma Patients." October 2016.

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Chinnadurai, R, Copland, IB, Garcia, MA, Petersen, CT, Lewis, CN, Waller, EK, Kirk, AD, and Galipeau, J. "Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing." Stem Cells (Dayton, Ohio) 34, no. 9 (September 2016): 2429-2442.

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Kirk, AD, Malchesky, PS, Shapiro, R, Webber, SA, Hirsch, HH, Marty, FM, Oberbauer, R, Wekerle, T, Bühler, LH, Labbate, A, Perry, K, and Wielgus, J. "Introducing the Wiley Transplant Peer Review Network." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 9 (September 2016): 2505-2507.

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Buchman, TG, Billiar, TR, Elster, E, Kirk, AD, Rimawi, RH, Vodovotz, Y, and Zehnbauer, BA. "Precision Medicine for Critical Illness and Injury." Critical Care Medicine 44, no. 9 (September 2016): 1635-1638.

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Oh, B, Yoon, J, Farris, A, Kirk, A, Knechtle, S, and Kwun, J. "Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 9 (September 2016): 2612-2623.

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