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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Koura, Divya T., John T. Horan, Amelia A. Langston, Muna Qayed, Aneesh Mehta, Hanna J. Khoury, R Donald Harvey, et al. “In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial.” Biol Blood Marrow Transplant 19, no. 11 (November 2013): 1638–49. https://doi.org/10.1016/j.bbmt.2013.09.003.

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Pena, Juan A., Lauren Titus, Jennifer Jackson, Allan D. Kirk, and Jennifer L. Gooch. “Differential regulation of calcineurin isoforms in transplant patients: a new look at an old problem.” Transplantation 96, no. 3 (August 15, 2013): 239–44. https://doi.org/10.1097/TP.0b013e31829acb64.

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O’Leary, J. G., H. M. Gebel, R. Ruiz, R. A. Bray, J. D. Marr, X. J. Zhou, S. M. Shiller, B. M. Susskind, A. D. Kirk, and G. B. Klintmalm. “Class II alloantibody and mortality in simultaneous liver-kidney transplantation.” Am J Transplant 13, no. 4 (April 2013): 954–60. https://doi.org/10.1111/ajt.12147.

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Lowe, M. C., I. R. Badell, A. P. Turner, P. W. Thompson, F. V. Leopardi, E. A. Strobert, C. P. Larsen, and A. D. Kirk. “Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy.” Am J Transplant 13, no. 2 (February 2013): 312–19. https://doi.org/10.1111/j.1600-6143.2012.04341.x.

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Lo, D. J., D. J. Anderson, T. A. Weaver, F. Leopardi, M. Song, A. B. Farris, E. A. Strobert, et al. “Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion.” Am J Transplant 13, no. 2 (February 2013): 320–28. https://doi.org/10.1111/j.1600-6143.2012.04342.x.

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Beus, Jonathan M., Salila S. Hashmi, Saranya A. Selvaraj, Danxia Duan, Linda L. Stempora, Stephanie A. Monday, Jennifer A. Cheeseman, et al. “Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection.” Plos One 8, no. 8 (2013): e71221. https://doi.org/10.1371/journal.pone.0071221.

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Velazquez, Victoria M., Huiming Hon, Chris Ibegbu, Stuart J. Knechtle, Allan D. Kirk, and Arash Grakoui. “Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection.” Hepatology 56, no. 6 (December 2012): 2071–81. https://doi.org/10.1002/hep.25904.

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