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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Shaw, Brian I., Hui-Jie Lee, Cliburn Chan, Robert Ettenger, Paul Grimm, Meghan Pearl, Elaine F. Reed, et al. “Relationship between antithymocyte globulin, T cell phenotypes, and clinical outcomes in pediatric kidney transplantation.” Am J Transplant 21, no. 2 (February 2021): 766–75. https://doi.org/10.1111/ajt.16263.

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Gerardo, Charles J., Elizabeth Silvius, Seth Schobel, John C. Eppensteiner, Lauren M. McGowan, Eric A. Elster, Allan D. Kirk, and Alexander T. Limkakeng. “Association of a Network of Immunologic Response and Clinical Features With the Functional Recovery From Crotalinae Snakebite Envenoming.” Front Immunol 12 (2021): 628113. https://doi.org/10.3389/fimmu.2021.628113.

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Manook, Miriam, Walter J. Flores, Robin Schmitz, Zachary Fitch, Janghoon Yoon, Yeeun Bae, Brian Shaw, et al. “Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model.” Front Immunol 12 (2021): 660900. https://doi.org/10.3389/fimmu.2021.660900.

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Mosca, P. J., S. Zani, M. M. Haglund, B. H. Collins, S. Wasiolek, T. N. Pappas, A. D. Kirk, and L. C. Cendales. “The Legacy of Joseph A. Moylan, M.D.: "it's about Everyone Else".” Annals of Surgery, January 1, 2021. https://doi.org/10.1097/AS9.0000000000000051.

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Schmitz, Robin, Zachary W. Fitch, He Xu, Ada Ghali, Aneesh K. Mehta, Antonio Guasch, and Allan D. Kirk. “Kidney transplantation using alemtuzumab, belatacept, and sirolimus: Five-year follow-up.” Am J Transplant 20, no. 12 (December 2020): 3609–19. https://doi.org/10.1111/ajt.16121.

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Calabrese, Leonard H., Roberto Caporali, Christian U. Blank, and Allan D. Kirk. “Modulating the wayward T cell: New horizons with immune checkpoint inhibitor treatments in autoimmunity, transplant, and cancer.” J Autoimmun 115 (December 2020): 102546. https://doi.org/10.1016/j.jaut.2020.102546.

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Vicente, Diego, Seth Schobel, Simone Anfossi, Hannah Hensman, Felipe Lisboa, Thomas Davis, Christopher John Dente, Allan Douglas Kirk, George Calin, and Eric Andrew Elster. “Characterization of Cellular and Viral MicroRNA in Polytrauma Patients.” In Journal of the American College of Surgeons, 231:E59–E59, 2020.

Scholars@Duke

Muñoz, Beau, Seth A. Schobel, Felipe A. Lisboa, Vivek Khatri, Scott F. Grey, Christopher J. Dente, Allan D. Kirk, Timothy Buchman, and Eric A. Elster. “Clinical risk factors and inflammatory biomarkers of post-traumatic acute kidney injury in combat patients.” Surgery 168, no. 4 (October 2020): 662–70. https://doi.org/10.1016/j.surg.2020.04.064.

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Atia, Andrew, Dimitrios Moris, MacKenzie McRae, Mingqing Song, Linda Stempora, Francis Leopardi, Kyha Williams, et al. “Th17 cell inhibition in a costimulation blockade-based regimen for vascularized composite allotransplantation using a nonhuman primate model.” Transpl Int 33, no. 10 (October 2020): 1294–1301. https://doi.org/10.1111/tri.13612.

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Levitsky, Josh, Bryna E. Burrell, Sai Kanaparthi, Laurence A. Turka, Sunil Kurian, Alberto Sanchez-Fueyo, Juan J. Lozano, et al. “Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus.” Hepatology 72, no. 2 (August 2020): 569–83. https://doi.org/10.1002/hep.31036.

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