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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Espinosa, JR, Mou, D, Adams, BW, DiBernardo, LR, MacDonald, AL, McRae, M, Miller, AN, Song, M, Stempora, LL, Wang, J, Iwakoshi, NN, and Kirk, AD. "T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice." Frontiers in Immunology 9 (January 2018): 1371-null.

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Adams, AB, Goldstein, J, Garrett, C, Zhang, R, Patzer, RE, Newell, KA, Turgeon, NA, Chami, AS, Guasch, A, Kirk, AD, Pastan, SO, Pearson, TC, and Larsen, CP. "Belatacept Combined With Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long-Term Renal Allograft Function." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 11 (November 2017): 2922-2936.

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Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Yoon, J, Yi, JS, Iwakoshi, N, Gibby, A, Hong, JJ, Farris, AB, Kirk, AD, and Knechtle, SJ. "Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates." Blood advances 1, no. 24 (November 2017): 2115-2119.

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Johnston, BE, Quigley, CA, Griffin, SM, Limkakeng, AT, Darrabie, MD, Cheeseman, JA, Kirk, AD, and Elster, EA. "313 Evaluation of Phenylalanine and Tyrosine Concentrations in Traumatically Injured Patients." October 2017.

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Dente, CJ, Bradley, M, Schobel, S, Gaucher, B, Buchman, T, Kirk, AD, and Elster, E. "Towards precision medicine: Accurate predictive modeling of infectious complications in combat casualties." The journal of trauma and acute care surgery 83, no. 4 (October 2017): 609-616.

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Ettenger, R, Chin, H, Kesler, K, Bridges, N, Grimm, P, Reed, EF, Sarwal, M, Sibley, R, Tsai, E, Warshaw, B, and Kirk, AD. "Relationship Among Viremia/Viral Infection, Alloimmunity, and Nutritional Parameters in the First Year After Pediatric Kidney Transplantation." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 6 (June 2017): 1549-1562.

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Samy, KP, Anderson, DJ, Lo, DJ, Mulvihill, MS, Song, M, Farris, AB, Parker, BS, MacDonald, AL, Lu, C, Springer, TA, Kachlany, SC, Reimann, KA, How, T, Leopardi, FV, Franke, KS, Williams, KD, Collins, BH, and Kirk, AD. "Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 5 (May 2017): 1193-1203.

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Belard, A, Buchman, T, Forsberg, J, Potter, BK, Dente, CJ, Kirk, A, and Elster, E. "Precision diagnosis: a view of the clinical decision support systems (CDSS) landscape through the lens of critical care." Journal of Clinical Monitoring and Computing 31, no. 2 (April 2017): 261-271. (Review)

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Modena, BD, Milam, R, Harrison, F, Cheeseman, JA, Abecassis, MM, Friedewald, JJ, Kirk, AD, and Salomon, DR. "Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 3 (March 2017): 712-723.

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Lee, J, Jackman, JG, Kwun, J, Manook, M, Moreno, A, Elster, EA, Kirk, AD, Leong, KW, and Sullenger, BA. "Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis." Biomaterials 120 (March 2017): 94-102.

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