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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Xu, H, Bendersky, VA, Brennan, TV, Espinosa, JR, and Kirk, AD. "IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 18, no. 3 (March 2018): 720-730.

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Belard, A, Buchman, T, Dente, CJ, Potter, BK, Kirk, A, and Elster, E. "The Uniformed Services University's Surgical Critical Care Initiative (SC2i): Bringing Precision Medicine to the Critically Ill." March 2018.

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Song, M, Mulvihill, MS, Williams, KD, Collins, BH, and Kirk, AD. "Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque." Journal of medical primatology 47, no. 1 (February 2018): 81-84.

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Lamanna, JJ, Gutierrez, J, Espinosa, JR, Wagner, J, Urquia, LN, Moreton, C, Victor Hurtig, C, Tora, M, Kirk, AD, Federici, T, and Boulis, NM. "Peripheral blood detection of systemic graft-specific xeno-antibodies following transplantation of human neural progenitor cells into the porcine spinal cord." Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 48 (February 2018): 173-180.

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Kwun, J, Park, J, Yi, JS, Farris, AB, Kirk, AD, and Knechtle, SJ. "IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade." Frontiers in Immunology 9 (January 2018): 2323-null.

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Daneshmand, MA, and Kirk, AD. "Immunosuppression in organ transplantation." In Fischer's Mastery of Surgery, Seventh Edition, 141-150. January 1, 2018.


Espinosa, JR, Mou, D, Adams, BW, DiBernardo, LR, MacDonald, AL, McRae, M, Miller, AN, Song, M, Stempora, LL, Wang, J, Iwakoshi, NN, and Kirk, AD. "T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice." Frontiers in Immunology 9 (January 2018): 1371-null.

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Adams, AB, Goldstein, J, Garrett, C, Zhang, R, Patzer, RE, Newell, KA, Turgeon, NA, Chami, AS, Guasch, A, Kirk, AD, Pastan, SO, Pearson, TC, and Larsen, CP. "Belatacept Combined With Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long-Term Renal Allograft Function." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 11 (November 2017): 2922-2936.

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Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Yoon, J, Yi, JS, Iwakoshi, N, Gibby, A, Hong, JJ, Farris, AB, Kirk, AD, and Knechtle, SJ. "Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates." Blood advances 1, no. 24 (November 2017): 2115-2119.

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Johnston, BE, Quigley, CA, Griffin, SM, Limkakeng, AT, Darrabie, MD, Cheeseman, JA, Kirk, AD, and Elster, EA. "313 Evaluation of Phenylalanine and Tyrosine Concentrations in Traumatically Injured Patients.": Elsevier BV, October 2017.

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