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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Aronson, Solomon, Sutton Murray, Gavin Martin, Jeanna Blitz, Timothy Crittenden, Mike E. Lipkin, Christopher R. Mantyh, et al. “Roadmap for Transforming Preoperative Assessment to Preoperative Optimization.” Anesth Analg 130, no. 4 (April 2020): 811–19.

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Corey, Kristin M., Joshua Helmkamp, Morgan Simons, Lesley Curtis, Keith Marsolo, Suresh Balu, Michael Gao, et al. “Assessing Quality of Surgical Real-World Data from an Automated Electronic Health Record Pipeline.” J Am Coll Surg 230, no. 3 (March 2020): 295-305.e12.

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Xu, He, Aneesh K. Mehta, Qimeng Gao, Hui-Jie Lee, Ada Ghali, Antonio Guasch, and Allan D. Kirk. “B cell reconstitution following alemtuzumab induction under a belatacept-based maintenance regimen.” Am J Transplant 20, no. 3 (March 2020): 653–62.

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Dente, Christopher John, Edda Styrmisdottir, Audrey Shi, Seth Schobel, Vivek Khatri, Benjamin K. Potter, Jonathan A. Forsberg, Timothy Buchman, Allan D. Kirk, and Eric Elster. “Driving biology: The effect of standardized wound management on wound biomarker profiles.” J Trauma Acute Care Surg 88, no. 3 (March 2020): 379–89.

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Blew, Kathryn H., Annabelle Chua, John Foreman, Rasheed Gbadegesin, Annette Jackson, Shashi Nagaraj, Rebecca Sadun, Del Wigfall, Allan D. Kirk, and Eileen T. Chambers. “Tailored use of belatacept in adolescent kidney transplantation.” Am J Transplant 20, no. 3 (March 2020): 884–88.

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Shaw, Brian I., Daniel K. Cheng, Chaitanya R. Acharya, Robert B. Ettenger, Herbert Kim Lyerly, Qing Cheng, Allan D. Kirk, and Eileen T. Chambers. “An age-independent gene signature for monitoring acute rejection in kidney transplantation.” Theranostics 10, no. 15 (2020): 6977–86.

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Shaw, B. I., H. J. Lee, C. Chan, R. Ettenger, P. Grimm, M. Pearl, E. F. Reed, et al. “Relationship between antithymocyte globulin, T cell phenotypes, and clinical outcomes in pediatric kidney transplantation.” American Journal of Transplantation, January 1, 2020.

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Gelbard, Rondi B., Hannah Hensman, Seth Schobel, Vivek Khatri, Brett M. Tracy, Christopher J. Dente, Timothy Buchman, Allan Kirk, and Eric Elster. “Random forest modeling can predict infectious complications following trauma laparotomy.” In J Trauma Acute Care Surg, 87:1125–32, 2019.

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Samy, Kannan P., Qimeng Gao, Robert Patrick Davis, Mingqing Song, Zachary W. Fitch, Michael S. Mulvihill, Andrea L. MacDonald, et al. “The role of human CD46 in early xenoislet engraftment in a dual transplant model.” Xenotransplantation 26, no. 6 (November 2019): e12540.

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Corey, Kristin, Joshua Helmkamp, Allan D. Kirk, Suresh Balu, David Thompson, Leila Mureebe, Joshua Watson, Keith Marsolo, Lesley Curtis, and Mark Sendak. “Assessing Quality of Real-World Data Supplied by an Automated Surgical Data Pipeline.” In Journal of the American College of Surgeons, 229:S89–S89. ELSEVIER SCIENCE INC, 2019.