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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Kwun, Jean, Jie Li, Clay Rouse, Jae Berm Park, Alton B. Farris, Maragatha Kuchibhatla, Joseph W. Turek, Stuart J. Knechtle, Allan D. Kirk, and M Louise Markert. “Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.” Jci Insight 5, no. 11 (June 4, 2020). https://doi.org/10.1172/jci.insight.129983.

Full Text

Lee, Frances T., Anil Dangi, Sahil Shah, Melanie Burnette, Yong-Guang Yang, Allan D. Kirk, Bernhard J. Hering, Stephen D. Miller, and Xunrong Luo. “Rejection of xenogeneic porcine islets in humanized mice is characterized by graft-infiltrating Th17 cells and activated B cells.” Am J Transplant 20, no. 6 (June 2020): 1538–50. https://doi.org/10.1111/ajt.15763.

Full Text

Schmitz, R., M. S. Mulvihill, Z. W. Fitch, T. How, F. Leopardi, and A. D. Kirk. “Altering Homeostatic Repopulation with Thymic Irradiation and Donor Mesenchymal Stem Cell Infusions in a Nonhuman Primate Model.” In American Journal of Transplantation, 20:710–710, 2020.

Scholars@Duke

Song, M., Z. Fitch, K. Samy, Q. Gao, R. P. Davis, F. Leopard, R. Schmitz, et al. “Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation.” In American Journal of Transplantation, 20:361–361, 2020.

Scholars@Duke

Shaw, B. I., R. Schmitz, D. M. Magnani, F. Leopardi, and A. D. Kirk. “Depletional Profiles of Human and Rhesus Specific Anti-Thymocyte Globulins in Rhesus Macaques.” In American Journal of Transplantation, 20:709–709, 2020.

Scholars@Duke

Shaw, B. I., H. Lee, C. Chan, R. B. Ettenger, P. Grimm, E. F. Reed, M. Sarwal, et al. “Obesity and Terminally Differentiated T Cells in Pediatric Kidney Transplantation.” In American Journal of Transplantation, 20:1012–1012, 2020.

Scholars@Duke

Aronson, Solomon, Gavin Martin, Padma Gulur, Mike E. Lipkin, Sandhya A. Lagoo-Deenadayalan, Christopher R. Mantyh, David E. Attarian, Joseph P. Mathew, and Allan D. Kirk. “Preoperative Optimization: A Continued Call to Action.” Anesth Analg 130, no. 4 (April 2020): 808–10. https://doi.org/10.1213/ANE.0000000000004492.

Full Text

Aronson, Solomon, Sutton Murray, Gavin Martin, Jeanna Blitz, Timothy Crittenden, Mike E. Lipkin, Christopher R. Mantyh, et al. “Roadmap for Transforming Preoperative Assessment to Preoperative Optimization.” Anesth Analg 130, no. 4 (April 2020): 811–19. https://doi.org/10.1213/ANE.0000000000004571.

Full Text

Fitch, Z. W., M. Song, R. Schmitz, F. Leopardi, M. Ribeiro, A. Miller, G. Devi, B. Collins, X. Luo, and A. D. Kirk. “Splenectomy Impedes B Cell Infiltration Associated with Rejection of Neonatal Porcine Islet Xenografts.” In American Journal of Transplantation, 20:757–757, 2020.

Scholars@Duke

Moris, D. P., A. Atia, M. Rae, M. Song, L. Stempora, F. Leopardi, K. Williams, et al. “Th17 Cell Inhibition in a Costimulation Blockade Based Regimen for Vascularized Composite Allotransplantation Using A Non-Human Primate Model.” In American Journal of Transplantation, 20:537–537, 2020.

Scholars@Duke

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