The research group, under the direction of Dr. Gayathri Devi, focuses on translational and clinical applications of programmed cell death signaling. Cell death is a critical process in tissue sculpting, adult cell homeostasis, for destruction of damaged cells and in pathobiology. We are, in particular, interested in elucidating molecular mechanisms of stress-induced cell survival/death signaling in normal and cancer cells and how this process regulates immune response.
Our work has identified the dominant role of a class of anti-cell death proteins called Inhibitor of Apoptosis Proteins (IAPs) in cancer cell survival and during development of acquired resistance to extrinsic and intrinsic death signals. Current funded research projects in the lab focus on innovative approaches toward immunosuppressive minimization, in vitro and in vivo tumor biology models, novel approaches toward islet xenotransplantation, and innovative preclinical models and strategies to modulate this anti-cell death.
Dr. Devi has also established a special research program to study inflammatory breast cancer (IBC), designated a rare and distinct type of breast cancer and a cancer health disparity by the National Cancer Institute (NCI).
Dr. Devi is an American Cancer Society Research Scholar Grant Awardee from Duke University. Prior to joining Duke, she received training in both academic research in the area of growth factor receptor signaling at Oregon Health and Sciences University, and in the biotechnology sector at AVI BioPharma, Inc. in the area of genomics-based anti-cancer drug development.
Key Projects Underway
- XIAP-NFκB tumor cell signaling in evasion of immune-mediated cell death
- Development of novel preclinical models/assays to study tumor emboli, dermal invasion, and lymphatic dissemination
- Understanding stromal tumor cell tropism and the development of nanotheranostics for inflammatory breast cancer therapy
- Molecular mechanisms of health disparities in inflammatory breast cancer; screening strategies and repurposing drugs to improve standard of care of locally advanced breast cancer
- Characterization of ToxCast environmental chemical library in anti-cancer therapeutic resistance
- Elucidating cell death mechanisms limiting xenotransplantation and defining strategies to improve islet survival
- Development of a program in multidisciplinary education and research in translational sciences (Duke MERITS)
Recent research highlights include the development of a novel redox modulation approach for breast cancer therapy. We have identified an adaptive stress-response signaling pathway (characterized by NFkB transcriptional signature) in locally advanced tumors, including inflammatory breast cancer. This finding has led to the discovery of the use of the FDA-approved drug disulfiram (DSF) when combined with copper to target pNFkB, cancer stem-like cells, and to increase tumor cell kill. These results were published in the Molecular Oncology Journal, 2015 (PMID: 25769405). The current goal of the collaborative team is to extend this to breast cancer clinical trials.
Our body of work has identified the central role of the X-linked inhibitor of apoptosis protein (XIAP) in adaptive stress-response signaling, which leads to both de novo and acquired resistance to cell death stimuli. In recently completed studies published in the Cell Death and Disease Journal (PMID: 26821068), we have discovered that XIAP expression can cause immunosuppression and is a critical modulator of responses to antibody-dependent cellular cytotoxity in cancer cells. We are developing strategies to target the effects of XIAP on the activation of caspases and pNFkB and the suppression of reactive oxygen species to enhance the activity of immunotherapy, chemotherapy, and EGFR/HER2-targeted drugs.
- Devi Awarded $1.6 Million for Inflammatory Breast Cancer Research, May 14, 2021
- Rare and Dangerous, October 1, 2017
- DOD Awards $1.2 Million To Study Breast Cancer Metastasis, May 5, 2017
- Study Shows How BPA May Affect Inflammatory Breast Cancer, March 28, 2017
- Devi Interview for her laboratory’s work on repurposing an anti-alcoholism drug for IBC therapy. WRAL June 10, 2015
- Dr. Devi was featured in the Women in STEM. Research Highlight and Interview for Women in Stem, Academic Minute, WAMC NPR affiliate, August 2015
- Dr. Devi – Era of Hope Investigator Highlight presentation
- BPA May Make Breast Cancer Cells Resistant To Treatment. WUNC, June 24, 2014
Research opportunities available for undergrads, med students, PhD candidates, etc.
Gayathri Devi, PhD
Publications and Funded Projects
View Dr. Devi's profile to see her publications and funded projects.
Trainees and Staff
- XuhuiXuhui Bao, MD, PhD
- Whitney Lane, MD
- Yuekun Zhu, MD
- Michael Brown, PhD (Duke Neurosurgery)
- Helen O. Oladapo née Onabanjo, MS, PhD (NCCU BRITE)
- Risa Gearhart
- Qimeng Gao (co-mentored with Dr. Kirk)
- Keith Vandusen (co-mentored with Dr. Brown)
- Samantha Bouchal
- Ulises Nino-Espino (Duke BSURF student)
- Jenna McMains (ECU student)
- Pranalee Patel
- Moises Tacam Jr
Research and Program Staff
- Mariana Ribeiro, MS
- Holly Hough, PhD
- Donna Crabtree, PhD
- Amanda McMillan (CTSI)
- Gail Morrah
Tumor cell signaling and immune response
Novel preclinical models/assays to study tumor emboli, dermal invasion, and lymphatic dissemination
- Mark W. Dewhirst, DVM, PhD
- Gregory M. Palmer, PhD
IBC health disparities, biomarkers, clinical, repurposing drugs, chemical screening
- John Stewart, MD
- Shelley Hwang, MD
- Paul Kelly Marcom, MD
- Jeffrey R. Marks, PhD
- Steven Patierno, PhD
- Donald McDonald, PhD
- Kimberly Lynn Blackwell, MD
- Richard DiGiulio, PhD
- Kevin Williams (NCCU)
- Imran Shah (EPA)
Islet biology and Xenotransplantation
News and Highlights
Dr. Devi and graduate student Risa Gearhart present an abstract titled, "Low Dose Exposure to an Environmental Chemical Mixture Increases Breast Cancer Cell Growth and Survival" at the 12th Annual Breast Cancer and the Environment Research Program (BCERP) Meeting, November 16-17, 2017 in Monrovia, CA.
Undergraduate student Ulises Nino-Espino presents his summer research at the State of North Carolina Undergraduate Research & Creativity Symposium (SNCURCS) on November 4, 2017 at Campbell University.
Dr. Gayathri Devi invited as the Martin and Winifred Ehlers Visiting Professor at Mayo Clinic in Rochester, MN. During this visit, she will present her research related to modulation of programmed cell death pathways for clinical applications and engage in discussions with the students and faculty in the Department of Biochemistry and Molecular Biology about developing educational training initiatives in translational sciences.
Graduate student Risa Gearhart presents a poster at DCI Annual Retreat (October 27) in the area of Superfund-derived chemical mixture in breast cancer risk and progression, a collaborative work with Dr. Rich Di Giulio at the Nicholas School of the Environment.
The Inflammatory Breast Cancer Research efforts featured in Duke Cancer Institute Breakthroughs Magazine.
The Association for Clinical and Translational Science (ACTS) has elected Gayathri Devi, PhD, Associate Professor in Surgery, Division of Surgical Sciences, to its Board of Directors. ACTS supports the Clinical and Translational Science Awards (CTSA) Program by advancing research, public policy, and education in clinical and translational science. ACTS members include leaders, investigators, and trainees from academic medical centers, government, industry, and philanthropy. The Board of Directors oversees all business and affairs of the association. Read the announcement
- Risa Gearhart receives a Basic Science Award at the Duke Surgery Annual Research Day for her abstract titled "Low-dose Exposure to a Polycyclic Aromatic Hydrocarbon (PAH) Mixture Promotes Breast Cancer Cell Proliferation: A Model Using Creosote-Contaminated Sediment from a Superfund Site"
- Gayathri Devi, PhD, presented an abstract related to the development and goals of the Duke MERITS Education program for the Advancement of Translational Sciences at the 2017 Association for Clinical and Translational Sciences (ACTS) Meeting April 19-21, 2017 in Washington, DC.
- Dr. Devi was invited as a visiting scientist at Saint Augustine Hospital and the University of Antwerp and served as an external examiner for the PhD defense of Melike Marsan at the University of Leuven.
- Dr. Devi – seminar speaker at University of Ghent, VIB Inflammation Research Center
- Dr. Devi was an invited speaker at the 5th International Inflammatory Breast Cancer meeting hosted by Harvard University, Boston.
- Shelley Hwang, Chief of Breast Surgery, Named One of TIME’s 100 Most Influential People for 2016
- Ronnie Shammas – 3rd Medical Student, Distinguished Poster Award and Section Winner, Duke Surgical Sciences Day
- Scott Sauer – Post doctoral fellow, Distinguished Poster Award, Duke Surgical Sciences Day
- Myron Evans, graduate student selected for late breaking abstract presentation at the AACR Annual Meeting, New Orleans. X-linked Inhibitor of Apoptosis Protein Induction by MAPK-eIF4G1 Pathway Drives NFκB Activation in Inflammatory Breast Cancer Growth and Therapeutic Resistance
- Dr. Devi was an invited speaker at MD Anderson Morgan Welch IBC Center, Houston, Feb 26 2016
- The Academic Minute: Gayathri Devi, Duke University – Breast Cancer Treatments (listen to audio)
- Dr. Devi, seminar speaker at Astrazeneca, Cambridge, London, July 22, 2015
- Duke study targets rare, inflammatory breast cancer treatment. WRAL News, June 6, 2015 (read the article)
- Scott Sauer – Presidential Poster Award Winner, Selected to present at Endocrine Disrupting Chemicals Press Conference and radio interviews with WUNC (NC PBS affiliate) and NC Health News Daily – International ENDO Conference, Chicago, IL
- Scott Sauer – T32 Viral Oncology Training Grant Awardee
New jobs from previous trainees
- Myron Evans (PhD 2016)– Postdoctoral Researcher at St. Jude’s Children’s Hospital
- Jennifer Allensworth (PhD 2014) – Clinical Research Coordinator at MD Anderson
- Amy Stefanowicz – Researcher at Humacyte
Awards from previous trainees
- Katherine Aird, Department of Defense Breast Cancer Research Program Pre-doctoral grant award, 2008
- Gayathri Devi, PhD, Chair (2007- present), Mentoring Committee, Women in Endocrinology, Endocrine Society
- Katherine Aird, 2006 DCCC Annual Meeting Abstract Winner
- Xiuyun Ding, PhD, and Katherine Aird, late-breaking abstract Presentations at AACR 2007
- Aris Baras won the Thomas J. Bardos AACR Science Education Award (2006)
- Aris Baras, 2005 Duke Undergraduate Research Award, Independent study project
- Gayathri Devi, PhD, awarded the Quest Diagnostic Young Investigator Award, Endocrine Society, 2005
- Gayathri Devi, PhD, Editorial Board Member (2005- present) Current Pharmaceutical Biotechnology Journal