Fall '21 Surgery Research Grant Activity and Awarded Clinical Trials
Research Grant Activity and Awarded Clinical Trials for Department of Surgery affiliates from April - October 2021.
Abdominal Transplant Surgery
Andrew S. Barbas, MD
"The Delivery of AAV Vector to Liver Allograft using Machine Perfusion System"
American Society of Transplant Surgeons
"Gene therapy of discarded human kidney grafts during 48 hours ex-vivo machine perfusion"
Asklepios BioPharmaceutical, Inc.
"Next Generation AAV Vectors for Kidney Gene Therapy"
BridgeBio Gene Therapy Research, Inc.
Allan D. Kirk, MD, PhD
"AX-158: Utilizing Nck Inhibition as Immunomodulation in Allotransplantation"
Artax Biopharma, Inc.
Stuart J. Knechtle, MD
"Targeting complement C3 to prevent acute antibody-mediated rejection for a deceased-donor kidney transplant in sensitized recipients"
Alexion Pharmaceuticals, Inc.
"Allo Vir ALVR105"
Allovir, Inc.
"Developing clinically relevant immunosuppressive regimen for pig to rhesus kidney transplantation using transgenic pigs"
eGenesis, Inc.
"Evaluation of anti-CD38mAb (MOR202) to desensitize highly sensitized non-human primates"
MorphoSys US Inc.
"Targeting the B Cell Response to Treat Antibody-Mediated Rejection"
National Institute of Allergy and Infectious Diseases
Jean Kwun, PhD
"Targeting complement C2 in a sensitized rat cardiac allograft model"
Alexion Pharmaceuticals, Inc.
Debra L. Sudan, MD
"Sample Collection for Prospera Enhancement by Detecting dd-cfDNA Levels (PEDAL Study)"
Natera, Inc
"Vectiv Bio - STARS - Pro00107052"
VectivBio AG
Cardiovascular and Thoracic Surgery
Jeffrey Gaca, MD
"RESTORE - Pro00106522"
Edwards Life Sciences Corporation
Donald D. Glower Jr., MD
"Outcome After Tricuspid Valve Repair With Tri-Ad Ring at Duke University - Pro00107182"
Medtronic, Inc.
"Abbott CRD 985 Annuplasty"
St. Jude Medical Inc.
Matthew Hartwig, MD
"BMI Service Agreement"
BioMedInnovations, LLC
"LUNGguard Registry"
Paragonix
George Hughes IV, MD
"TRIOMPHE Study - Pro00107432"
Endospan, Ltd
"Terumo Aortic PANTHER"
Vascutek Limited
Carmelo Milano, MD
"Abbott Swift"
Abbott Laboratories
Jacob Schroder, MD
"Guardian Registry"
Paragonix
Peter Smith, MD
"CTSN Coordinating Center for ACTIV-3b (TESICO) for Hospitalized Patients with ARDS Associated with COVID-19"
Icahn School of Medicine at Mount Sinai
Emergency Medicine
Stephanie Ann Eucker, MD, PhD
"Emergency Department Acupuncture for Musculoskeletal Pain Management"
Substance Abuse and Mental Health Services Administration
"PROmotion of COVid-19 VA(X)ccination in the Emergency Department - PROCOVAXED"
University of California - San Francisco
Samuel Francis, MD
"An examination of coagulation and inflammatory response of healthy donor whole blood "
BTG International Inc
Charles Gerardo, MD
"Using community health centers to mitigate the impact of snakebite envenoming in low resource areas"
Fogarty International Center
"Snakebite OPX-PR-01"
Ophirex, Inc
Julian T. Hertz, MD
"Barriers to myocardial infarction care among persons living with HIV in Tanzania"
Society for Academic Emergency Medicine
Alexander Limkakeng Jr., MD, MHS
"EPPIC-NET Centrexion Knee OA (EN20-01)"
Massachusetts General Hospital
"Sense Diagnostics"
Sense Diagnostics, Inc
Metabolic and Weight Loss Surgery
A. Daniel Guerron, MD
"A Retrospective Multicenter Comparison of Laparoscopic and Robotic-Assisted Roux-en-Y Gastric Bypass and Sleeve Gastrectomy"
Intuitive Surgical, Inc.
Scott Thomas Hollenbeck, MD
"Assessing Adipose Senescence As a Predictor of Graft Survival and Volume Retention"
Southeastern Society of Plastic and Reconstructive Surgeons
"BMQ - Pro00107672"
BIOMILQ
Keri Seymour, DO
"Automatic Metal Ligation Appliers VS WECK Hem-o-Lok Polymer Ligation System"
Teleflex, Inc.
Plastic, Maxillofacial, and Oral
Brett Phillips, MD, MBA
"A Multi-institutional Randomized Controlled Trial to Determine the Optimal Antibiotic Prophylaxis for Tissue Expander-based Breast Reconstruction"
The Plastic Surgery Foundation
Pediatric General Surgery
Tamara Fitzgerald, MD, PhD
"Increasing Accessibility of Laparoscopic Surgery in Low- and Middle-Income Countries"
National Cancer Institute
Surgical Oncology
Eun-Sil Shelley Hwang, MD, MPH
"Validation and Implementation of a Machine learning solutions for Surgical Peri-operative workflow"
Verily Life Sciences, LLC
Michael Lidsky, MD
"Exploitation of XLF signaling and the DNA Damage Response as a novel therapeutic strategy in cholangiocarcinoma"
American College of Surgeons
Sabino Zani Jr., MD
"Tumor-Draining Lymph Node B Cells as Regulators of Melanoma Progression"
National Institutes of Health
Surgical Sciences
Aravind Asokan, PhD
"Next Generation AAV Vectors for Kidney Gene Therapy"
BridgeBio Gene Therapy Research, Inc.
Dawn Bowles, PhD
"Fortilin, CTNNA3, and the Heart"
University of Washington
Chin-Ho Chen, PhD
"New Non-Nuceleotide Reverse Transcriptase Inhibitors for Drug Resistant HIV Strains"
National Institute of Allergy and Infectious Diseases
Gayathri R. Devi, PhD
"Overcome Stress Signaling to Prevent Inflammatory Breast Cancer Metastasis"
American Cancer Society, Inc.
Stephanie Jost, MS, PhD
"NK cell responses to JC polyomavirus"
Beth Israel Deaconess Medical Center
David C. Montefiori, PhD
"Neutralizing Antibody Response Assessment for a Phase 2/3 Randomized, Observer-Blind, Placebo-Controlled, Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 SARS-CoV-2 Vaccine"
Moderna Therapeutics, Inc.
"A PHASE 2a, RANDOMIZED, OBSERVER-BLIND, PLACEBO-CONTROLLED, DOSE-CONFIRMATION STUDY TO EVALUATE THE SAFETY, REACTOGENICITY, AND IMMUNOGENICITY OF MRNA-1273 SARS-COV-2 VACCINE IN ADULTS AGED 18 YEARS A"
Moderna Therapeutics, Inc.
"Moderna mRNA-1273 P201 (Part B) Trial Neutralizing Antibody Assessment"
Moderna Therapeutics, Inc.
"A Phase 2/3, Two-Part, Open-Label, Dose-Escalation, Age De-escalation and Randomized, Observer-Blind, Placebo-Controlled, Expansion Study to Evaluate the Safety, Tolerability, Reactogenicity, and Effe"
Moderna Therapeutics, Inc.
"Moderna mRNA1275 P205 Trial Neutralizing Antibody Assessment"
Moderna Therapeutics, Inc.
"A Phase 3b, Open-Label, Safety and Immunogenicity Study of SARS-CoV-2 mRNA-1273 Vaccine in Adult Solid Organ Transplant Recipients and Healthy Controls"
Moderna Therapeutics, Inc.
"A Phase 1, Randomized, Observer-Blind, Dose-Ranging Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1283 and mRNA-1273 SARS-CoV-2 Vaccine in Adults Aged 18-55 Years"
Moderna Therapeutics, Inc.
Smita Nair, PhD
"Molecular and Immunologic Characterization of In-Transit Melanoma"
Melanoma Research Alliance
Roger Keith Reeves, PhD
"NK cell mobilization as a pathogenic etiology of SARSCoV2 gastrointestinal disease"
National Institute of Diabetes and Digestive and Kidney Diseases
"Fine Mechanisms of Adaptive NK Cell Formation Against HIV and SIV"
National Institute of Allergy and Infectious Diseases
"Natural killer cell receptor-expressing B cells as regulators of mucosal immunity in SIV infection"
National Institute of Allergy and Infectious Diseases
"Antigen-Specific NK Cell Memory Against SIV and HIV Vaccines"
National Institutes of Health
"Mechanisms of Natural Killer Cell Clearance of SIV from Lymphoid Follicles"
National Institutes of Health
"Microbial and innate immune mechanisms of oral inflammation during SIV infection"
National Institutes of Health
Xiaoying Shen, PhD
"HHSN272201800004C-Option 10"
National Institutes of Health
"Nonhuman Primate Option 3"
National Institutes of Health
Georgia D. Tomaras, PhD
"Impact of Antibody Effector Function Diversity on Antiviral Activity In Situ"
National Institute of Allergy and Infectious Diseases
"Sanofi Coronavirus Studies"
Sanofi Pasteur, Inc
"HVTN TB Supplement"
Fred Hutchinson Cancer Research Center
Trauma, Acute, and Critical Care Surgery
Joseph Fernandez-Moure, MD, MS
"Resorbable, Phsophorylated Poly(ester urea) Surgical Adhesive to Enhance Fracture Healing"
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Sean Paul Montgomery, MD
"Artificial Intelligence for point of care ultrasound"
Kitware Inc.
Urology
Brant A. Inman, MD, MS
"A Phase 3, Multi-center, Randomized Study Evaluating Efficacy of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-Invasive Urothelial Carcinoma (M"
Janssen Research & Development, LLC
Deborah Kaye, MD, MS
"Decreasing the Financial Burden for Patients with Advanced Prostate Cancer By Understanding Provider Decision-Making"
American Urological Association Foundation
Aaron Lentz, MD
"IT MATTERS Pro00108660"
Boston Scientific Corporation
Michael E. Lipkin, MD
"MOSES Laser RCT - Pro00104482"
Mayo Clinic Hospital - Arizona
J Todd Purves, MD, PhD
"A Two-part, Multicenter, Dose-titration Study Evaluating the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Oxybutynin Chloride 10% Gel for the Treatment of Detrusor Overactivity Associat"
Allergan Sales, LLC
Jonathan Routh, MD, MPH
"DICERNA PHXC 502 Study"
Dicerna Pharmaceuticals, Inc.
Vascular and Endovascular Surgery
Kevin Southerland, MD
"Macrophage-Satellite Cell Interactions in the Ischemic Limb"
Vascular Cures
Give to Duke Surgery
A gift to the Department of Surgery is a gift of knowledge, discovery, and life.