Skip to main content

Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin at Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Weill Cornell Medical College, 1982

Publications

Tyson, Mark D., Eric S. Wisenbaugh, Paul E. Andrews, Erik P. Castle, and Mitchell R. Humphreys. “Simultaneous kidney transplantation and bilateral native nephrectomy for polycystic kidney disease..” J Urol 190, no. 6 (December 2013): 2170–74. https://doi.org/10.1016/j.juro.2013.05.057.

Full Text

Ruhil, Ravi, Daniel Huang, Ozlem P. Bulut, Stuart J. Knechtle, Leslie S. Kean, and Neal N. Iwakoshi. “Humoral Immunity Induced By Viral Infection Provides a Major Barrier To Hematopoietic Cell Transplantation.” In Blood, 122:894–894. American Society of Hematology, 2013. https://doi.org/10.1182/blood.v122.21.894.894.

Full Text

Morris, P. J., and S. Knechtle. “Kidney Transplantation-Principles and Practice: Seventh Edition.” Kidney Transplantation Principles and Practice: Seventh Edition, November 1, 2013, 1–758.

Scholars@Duke

Page, Eugenia K., Cynthia L. Courtney, Prachi Sharma, Jennifer Cheeseman, Joe B. Jenkins, Elizabeth Strobert, and Stuart J. Knechtle. “Post-transplant lymphoproliferative disorder associated with immunosuppressive therapy for renal transplantation in rhesus macaques (Macaca mulatta)..” Exp Toxicol Pathol 65, no. 7–8 (November 2013): 1019–24. https://doi.org/10.1016/j.etp.2013.02.005.

Full Text

Suthanthiran, Manikkam, Joseph E. Schwartz, Ruchuang Ding, Michael Abecassis, Darshana Dadhania, Benjamin Samstein, Stuart J. Knechtle, et al. “Urinary-cell mRNA profile and acute cellular rejection in kidney allografts..” N Engl J Med 369, no. 1 (July 4, 2013): 20–31. https://doi.org/10.1056/NEJMoa1215555.

Full Text

Pages