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Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Selected Grants

Publications

Newell, K. A., A. Asare, I. Sanz, C. Wei, A. Rosenberg, Z. Gao, S. Kanaparthi, et al. “Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.” Am J Transplant 15, no. 11 (November 2015): 2908–20. https://doi.org/10.1111/ajt.13480.

Full Text

Burghuber, C. K., J. Kwun, E. J. Kim, F. V. Leopardi, A. C. Gibby, N. N. Iwakoshi, and S. J. Knechtle. “NEW DESENSITIZATION STRATEGY IN A KIDNEY TRANSPLANTATION MODEL WITH RHESUS MONKEYS.” In Transplant International, 28:12–12. WILEY-BLACKWELL, 2015.

Scholars@Duke

Reed, Alan, William C. Chapman, Stuart Knechtle, Kenneth Chavin, Richard Gilroy, and Goran B. G. Klintmalm. “Equalizing MELD Scores Over Broad Geographies Is Not the Most Efficacious Way to Allocate a Scarce Resource in a Value-based Environment.” Ann Surg 262, no. 2 (August 2015): 220–23. https://doi.org/10.1097/SLA.0000000000001331.

Full Text

Kokabi, Nima, Juan C. Camacho, Minzhi Xing, Bassel F. El-Rayes, James R. Spivey, Stuart J. Knechtle, and Hyun S. Kim. “Open-label prospective study of the safety and efficacy of glass-based yttrium 90 radioembolization for infiltrative hepatocellular carcinoma with portal vein thrombosis.” Cancer 121, no. 13 (July 1, 2015): 2164–74. https://doi.org/10.1002/cncr.29275.

Full Text

Kwun, J., E. Page, J. J. Hong, A. Gibby, J. Yoon, A. B. Farris, F. Villinger, and S. Knechtle. “Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.” Am J Transplant 15, no. 3 (March 2015): 815–22. https://doi.org/10.1111/ajt.13045.

Full Text

Velazquez, Victoria M., Luke S. Uebelhoer, Manoj Thapa, Chris C. Ibegbu, Cynthia Courtney, Steven E. Bosinger, Joseph F. Magliocca, et al. “Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development.” Hepatology 61, no. 3 (March 2015): 843–56. https://doi.org/10.1002/hep.27575.

Full Text

Shaffer, Katherine, Sungjin Kim, Anthony M. Gamboa, Jennifer A. Luke, Sunil Dacha, Andrew B. Adams, Stuart J. Knechtle, et al. “Incidence and Predictors of Lymph Nodal Metastases in Patients With Cholangiocarcinoma in the United States.” In Gastroenterology, 146:S994–S994. W B SAUNDERS CO-ELSEVIER INC, 2014.

Scholars@Duke

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