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Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Selected Grants

Publications

D’Alessandro, A. M., D. F. Lorentzen, J. D. Pirsch, S. J. Knechtle, A. Reed, R. M. Hoffmann, M. J. Armbrust, H. W. Sollinger, M. Kalayoglu, and F. O. Belzer. “Cadaveric renal transplantation in the cyclosporine and OKT3 eras: an update of the University of Wisconsin-Madison experience.” Clin Transpl, 1989, 239–51.

Scholars@Duke

Bollinger, R. R., S. J. Knechtle, R. C. Harland, Y. Yamaguchi, and E. C. Halperin. “New approaches to immunosuppression for xenotransplantation.” In Xenograft 25: Proceedings of the International Congress, Xenograft 25. Ics880, 45–54, 1989.

Scholars@Duke

HARLAND, R. C., S. J. KNECHTLE, Y. YAMAGUCHI, and R. R. BOLLINGER. “ANTIBODY-TITERS AND CARDIAC ALLOGRAFT SURVIVAL IN THE SENSITIZED RAT MODEL - EFFECT OF TIME AFTER INITIAL SENSITIZATION.” Transplantation Proceedings 20, no. 1 (February 1, 1988): 839–41.

Scholars@Duke

Halperin, E. C., S. Knechtle, K. Abernethy, T. Saad, D. Miller, W. B. Vernon, and R. R. Bollinger. “The influence of dose and dose rate of total lymphoid irradiation in the rat cardiac allograft model.” Radiother Oncol 9, no. 4 (August 1987): 311–18. https://doi.org/10.1016/s0167-8140(87)80152-4.

Full Text

Knechtle, S. J., E. C. Halperin, and R. R. Bollinger. “Combined total lymphoid irradiation and cyclosporine promote xenograft survival.” Transplant Proc 19, no. 1 Pt 2 (February 1987): 1137–39.

Scholars@Duke

Knechtle, S. J., P. C. Kolbeck, S. Tsuchimoto, A. Coundouriotis, F. Sanfilippo, and R. R. Bollinger. “Humoral rejection of rat hepatic transplants by passive transfer of serum.” Transplant Proc 19, no. 1 Pt 2 (February 1987): 1072–76.

Scholars@Duke

Knechtle, S. J., J. A. Wolfe, J. Burchette, F. Sanfilippo, and R. R. Bollinger. “Infiltrating cell phenotypes and patterns associated with hepatic allograft rejection or acceptance.” Transplantation 43, no. 2 (February 1987): 169–72. https://doi.org/10.1097/00007890-198702000-00001.

Full Text

Knechtle, S. J., K. Kempf, and R. R. Bollinger. “Peptic ulcer disease following renal transplantation.” Transplant Proc 19, no. 1 Pt 3 (February 1987): 2233–36.

Scholars@Duke

Wolfe, J. A., S. J. Knechtle, J. Burchette, R. R. Bollinger, and F. Sanfilippo. “Phenotype and patterns of inflammatory cell infiltration associated with rejection or acceptance of rat liver allografts.” Transplant Proc 19, no. 1 Pt 1 (February 1987): 364–68.

Scholars@Duke

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