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Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin at Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Weill Cornell Medical College, 1982

Publications

Barbas, A. S., and S. J. Knechtle. “Expanding the Donor Pool With Normothermic Ex Vivo Liver Perfusion: The Future Is Now..” Am J Transplant 16, no. 11 (November 2016): 3075–76. https://doi.org/10.1111/ajt.13959.

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Demetris, A. J., C. Bellamy, S. G. Hübscher, J. O’Leary, P. S. Randhawa, S. Feng, D. Neil, et al. “2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection..” Am J Transplant 16, no. 10 (October 2016): 2816–35. https://doi.org/10.1111/ajt.13909.

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Oh, B., J. Yoon, A. Farris, A. Kirk, S. Knechtle, and J. Kwun. “Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig..” Am J Transplant 16, no. 9 (September 2016): 2612–23. https://doi.org/10.1111/ajt.13789.

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Burghuber, C. K., J. Kwun, E. J. Page, M. Manook, A. C. Gibby, F. V. Leopardi, M. Song, et al. “Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology..” Am J Transplant 16, no. 6 (June 2016): 1726–38. https://doi.org/10.1111/ajt.13688.

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Ludwig, Johannes M., Stuart J. Knechtle, and Hyun S. Kim. “Reply to: "Percutaneous Management of Benign Biliary Strictures: Is It Time to Focus on Reducing Procedure Invasiveness?"..” J Vasc Interv Radiol 27, no. 6 (June 2016): 936–37. https://doi.org/10.1016/j.jvir.2016.03.003.

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Ludwig, Johannes M., Grant R. Webber, Stuart J. Knechtle, James R. Spivey, Minzhi Xing, and Hyun S. Kim. “Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation..” J Vasc Interv Radiol 27, no. 2 (February 2016): 219-225.e1. https://doi.org/10.1016/j.jvir.2015.10.021.

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Suhre, Karsten, Joseph E. Schwartz, Vijay K. Sharma, Qiuying Chen, John R. Lee, Thangamani Muthukumar, Darshana M. Dadhania, et al. “Urine Metabolite Profiles Predictive of Human Kidney Allograft Status..” J Am Soc Nephrol 27, no. 2 (February 2016): 626–36. https://doi.org/10.1681/ASN.2015010107.

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Halazun, K. J., A. K. Mathur, A. A. Rana, A. B. Massie, S. Mohan, R. E. Patzer, J. P. Wedd, et al. “One Size Does Not Fit All--Regional Variation in the Impact of the Share 35 Liver Allocation Policy..” Am J Transplant 16, no. 1 (January 2016): 137–42. https://doi.org/10.1111/ajt.13500.

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