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Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Selected Grants

Publications

Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119.” Blood Adv 2, no. 2 (January 23, 2018): 89. https://doi.org/10.1182/bloodadvances.2017015446.

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Kwun, Jean, Jaeberm Park, John S. Yi, Alton B. Farris, Allan D. Kirk, and Stuart J. Knechtle. “IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.” Front Immunol 9 (2018): 2323. https://doi.org/10.3389/fimmu.2018.02323.

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Kwun, Jean, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, et al. “Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates.” Blood Adv 1, no. 24 (November 14, 2017): 2115–19. https://doi.org/10.1182/bloodadvances.2017010991.

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Ezekian, Brian, Michael S. Mulvihill, Kyle Freischlag, Babatunde A. Yerokun, Robert P. Davis, Matthew G. Hartwig, Stuart J. Knechtle, and Andrew S. Barbas. “Elevated HbA1c in donor organs from patients without a diagnosis of diabetes portends worse liver allograft survival.” Clin Transplant 31, no. 9 (September 2017). https://doi.org/10.1111/ctr.13047.

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Dendy, Meaghan S., Juan C. Camacho, Johannes M. Ludwig, Alyssa M. Krasinskas, Stuart J. Knechtle, and Hyun S. Kim. “Infiltrative Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Treated With a Single High-Dose Y90 Radioembolization and Subsequent Liver Transplantation Without a Recurrence.” Transplantation Direct 3, no. 9 (September 2017): e206. https://doi.org/10.1097/txd.0000000000000707.

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Manook, M., J. Kwun, C. Burghuber, K. Samy, M. Mulvihill, J. Yoon, H. Xu, et al. “Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.” Am J Transplant 17, no. 8 (August 2017): 2055–64. https://doi.org/10.1111/ajt.14234.

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Kwun, Jean, Christopher Burghuber, Miriam Manook, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, and Stuart Knechtle. “Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients.” J Am Soc Nephrol 28, no. 7 (July 2017): 1991–96. https://doi.org/10.1681/ASN.2016070727.

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Kwun, Jean, Miriam Manook, Eugenia Page, Christopher Burghuber, Jungjoo Hong, and Stuart J. Knechtle. “Crosstalk Between T and B Cells in the Germinal Center After Transplantation.” Transplantation 101, no. 4 (April 2017): 704–12. https://doi.org/10.1097/TP.0000000000001588.

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Xing, Minzhi, Sonali Sakaria, Renumathy Dhanasekaran, Samir Parekh, James Spivey, Stuart J. Knechtle, Di Zhang, and Hyun S. Kim. “Bridging Locoregional Therapy Prolongs Survival in Patients Listed for Liver Transplant with Hepatocellular Carcinoma.” Cardiovasc Intervent Radiol 40, no. 3 (March 2017): 410–20. https://doi.org/10.1007/s00270-016-1505-0.

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Schadde, Erik, Christopher Tsatsaris, Marzena Swiderska-Syn, Stefan Breitenstein, Martin Urner, Roman Schimmer, Christa Booy, et al. “Hypoxia of the growing liver accelerates regeneration.” Surgery 161, no. 3 (March 2017): 666–79. https://doi.org/10.1016/j.surg.2016.05.018.

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