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Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin at Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Weill Cornell Medical College, 1982

Publications

Freischlag, Kyle, Paul M. Schroder, Brian Ezekian, Morgan L. Cox, Michael S. Mulvihill, Matthew G. Hartwig, and Stuart J. Knechtle. “Improved survival in simultaneous lung-liver recipients and candidates in the modern era of lung allocation..” J Surg Res 231 (November 2018): 395–402. https://doi.org/10.1016/j.jss.2018.06.007.

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Moris, Dimitrios, Diamantis Tsilimigras, Jenny Lim, Danielle Camastra, Aditya Nanavati, Stuart Knechtle, and Andrew Barbas. “Neuroendocrine carcinomas of the gallbladder: Lessons learnt from cases at opposite ends of the spectrum..” J Buon 23, no. 6 (November 2018): 1922–26.

Scholars@Duke

Wood, Amber M., Chad A. Grotegut, James Ronald, Waleska Pabon-Ramos, Christina Pedro, Stuart J. Knechtle, Ewa Wysokinska, Geoffrey D. Rubin, Carla W. Brady, and Jennifer B. Gilner. “Identification and Management of Abdominal Wall Varices in Pregnancy..” Obstet Gynecol 132, no. 4 (October 2018): 882–87. https://doi.org/10.1097/AOG.0000000000002805.

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Patel, Yuval A., Jacqueline B. Henson, Julius M. Wilder, Jiayin Zheng, Schein-Chung Chow, Carl L. Berg, Stuart J. Knechtle, and Andrew J. Muir. “The impact of human leukocyte antigen donor and recipient serotyping and matching on liver transplant graft failure in primary sclerosing cholangitis, autoimmune hepatitis, and primary biliary cholangitis..” Clin Transplant 32, no. 10 (October 2018). https://doi.org/10.1111/ctr.13388.

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Ezekian, Brian, Paul M. Schroder, Kyle Freischlag, Janghoon Yoon, Jean Kwun, and Stuart J. Knechtle. “Contemporary Strategies and Barriers to Transplantation Tolerance..” Transplantation 102, no. 8 (August 2018): 1213–22. https://doi.org/10.1097/TP.0000000000002242.

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Manook, Miriam, Jean Kwun, Steven Sacks, Anthony Dorling, Nizam Mamode, and Stuart Knechtle. “Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient..” Transplant Rev (Orlando) 32, no. 3 (July 2018): 119–26. https://doi.org/10.1016/j.trre.2018.01.001.

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Tambur, Anat R., Patricia Campbell, Frans H. Claas, Sandy Feng, Howard M. Gebel, Annette M. Jackson, Roslyn B. Mannon, et al. “Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report..” Am J Transplant 18, no. 7 (July 2018): 1604–14. https://doi.org/10.1111/ajt.14752.

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Barbas, Andrew S., Martin J. Dib, Aparna S. Rege, Deepak S. Vikraman, Debra L. Sudan, Stuart J. Knechtle, and John E. Scarborough. “The Volume-outcome Relationship in Deceased Donor Kidney Transplantation and Implications for Regionalization..” Ann Surg 267, no. 6 (June 2018): 1169–72. https://doi.org/10.1097/SLA.0000000000002351.

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Freischlag, Kyle William, Julia Messina, Brian Ezekian, Michael S. Mulvihill, Andrew Barbas, Carl Berg, Debra Sudan, John Reynolds, Matthew Hartwig, and Stuart Knechtle. “Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes..” Transplant Direct 4, no. 5 (May 2018). https://doi.org/10.1097/TXD.0000000000000785.

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Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119..” Blood Adv 2, no. 2 (January 23, 2018). https://doi.org/10.1182/bloodadvances.2017015446.

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