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Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Selected Grants

Publications

Bulut, O. P., R. Ruhil, B. Oh, S. J. Knechtle, S. Talebagha, and N. N. Iwakoshi. “Phenotypic and Functional Analysis of Long-Lived Alloreactive Plasma Cells.” In American Journal of Transplantation, 12:51–51. WILEY-BLACKWELL, 2012.

Scholars@Duke

Oh, B., J. Kwun, R. Ruhil, A. Gibby, E. Page, V. Lu, D. Kim, et al. “Rapamycin Enhances Donor-Specific Antibody and Chronic Rejection of Full MHC Mismatched Cardiac Allografts after Alemtuzumab Treatment.” In American Journal of Transplantation, 12:463–463. WILEY-BLACKWELL, 2012.

Scholars@Duke

Magliocca, J. F., L. K. Kayler, S. I. Hanish, S. J. Knechtle, and J. D. Schold. “Significantly Greater Hazard Associated with the Use of Older Donor Livers in HCV plus Recipients.” In American Journal of Transplantation, 12:516–17. WILEY-BLACKWELL, 2012.

Scholars@Duke

Kwun, J., B. Oh, A. Gibby, N. Iwakoshi, and S. J. Knechtle. “The Role of CD4(+)CD25(+) T reg Cells on Alloantibody Production in a Model of Chronic Rejection after T Cell Depletion.” In American Journal of Transplantation, 12:447–447. WILEY-BLACKWELL, 2012.

Scholars@Duke

Kwun, Jean, Pinar Bulut, Eugenia Kim, Wasim Dar, Byoungchol Oh, Ravi Ruhil, Neal Iwakoshi, and Stuart J. Knechtle. “The role of B cells in solid organ transplantation.” Semin Immunol 24, no. 2 (April 2012): 96–108. https://doi.org/10.1016/j.smim.2011.08.022.

Full Text

Becker-Weidman, David J. S., Bobby Kalb, Puneet Sharma, Hiroumi D. Kitajima, Christina R. Lurie, Zhengjia Chen, James R. Spivey, et al. “Hepatocellular carcinoma lesion characterization: single-institution clinical performance review of multiphase gadolinium-enhanced MR imaging--comparison to prior same-center results after MR systems improvements.” Radiology 261, no. 3 (December 2011): 824–33. https://doi.org/10.1148/radiol.11110157.

Full Text

Kwun, Jean, Subramaniam Malarkannan, William J. Burlingham, and Stuart J. Knechtle. “Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.” J Immunol 187, no. 8 (October 15, 2011): 3997–4006. https://doi.org/10.4049/jimmunol.1003918.

Full Text

Gupta, Nitika A., Vasantha L. Kolachala, Rong Jiang, Carlos R. Abramowsky, Stuart J. Knechtle, and Allan D. Kirk. “PORTAL VENOUS FLOW ABNORMALITIES ARE PRESENT AND ARE ACCENTUATED AFTER ISCHEMIA REPERFUSION INJURY OF A STEATOTIC LIVER.” In Hepatology, 54:1168A-1168A. WILEY-BLACKWELL, 2011.

Scholars@Duke

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