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Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Selected Grants

Publications

Magliocca, J. F., L. K. Kayler, S. I. Hanish, S. J. Knechtle, and J. D. Schold. “Significantly Greater Hazard Associated with the Use of Older Donor Livers in HCV+ Recipients.” Transplantation Journal 94, no. 10S (November 2012): 426–426. https://doi.org/10.1097/00007890-201211271-00804.

Full Text

Magliocca, J. F., L. K. Kayler, S. I. Hanish, S. J. Knechtle, and J. D. Schold. “Significantly Greater Hazard Associated with the Use of Older Donor Livers in HCV+ Recipients.” Transplantation Journal 94, no. 10S (November 2012): 107–107. https://doi.org/10.1097/00007890-201211271-00196.

Full Text

Gupta, Nitika A., Vasantha L. Kolachala, Rong Jiang, Carlos Abramowsky, Rene Romero, Nimita Fifadara, Frank Anania, Stuart Knechtle, and Allan Kirk. “The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis.” Am J Pathol 181, no. 5 (November 2012): 1693–1701. https://doi.org/10.1016/j.ajpath.2012.07.015.

Full Text

Kwun, J., B. C. Oh, A. C. Gibby, R. Ruhil, V. T. Lu, D. W. Kim, E. K. Page, et al. “Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.” Am J Transplant 12, no. 10 (October 2012): 2641–51. https://doi.org/10.1111/j.1600-6143.2012.04181.x.

Full Text

Best, Victoria, Stuart J. Knechtle, Allan D. Kirk, and Arash Grakoui. “Potential role for intrahepatic CD34+cells in immunity to hepatitis C virus.” In Hepatology, 56:1109A-1110A. WILEY-BLACKWELL, 2012.

Scholars@Duke

Page, E. K., A. J. Page, J. Kwun, A. C. Gibby, F. Leopardi, J. B. Jenkins, E. A. Strobert, et al. “Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.” Am J Transplant 12, no. 9 (September 2012): 2395–2405. https://doi.org/10.1111/j.1600-6143.2012.04074.x.

Full Text

Page, E. K., A. C. Gibby, J. Kwun, F. Leopardi, A. B. Adams, C. L. Courtney, J. B. Jenkins, E. Strobert, N. Iwakoshi, and S. J. Knechtle. “Belatacept Prevents De Novo Alloantibody Production in Rhesus Macaques.” In American Journal of Transplantation, 12:276–276. WILEY-BLACKWELL, 2012.

Scholars@Duke

Page, E. K., A. J. Page, J. Kwun, A. C. Gibby, F. Leopardi, E. Strobert, J. B. Jenkins, et al. “Enhanced De Novo Alloantibody and Antibody-Mediated Injury in Rhesus Macaques.” In American Journal of Transplantation, 12:51–51. WILEY-BLACKWELL, 2012.

Scholars@Duke

Kwun, J., B. Oh, A. Gibby, R. Ruhil, V. Lu, O. P. Bulut, M. Song, et al. “Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection after Alemtuzumab Treatment.” In American Journal of Transplantation, 12:278–278. WILEY-BLACKWELL, 2012.

Scholars@Duke

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