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Stuart Johnston Knechtle, MD

William R. Kenan, Jr. Distinguished Professor
Professor of Surgery
Adjunct Professor in the Department of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin at Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Weill Cornell Medical College, 1982

Publications

Fitch, Zachary, Robin Schmitz, Jean Kwun, Bernhard Hering, Joren Madsen, and Stuart J. Knechtle. “Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation..” Transplant Rev (Orlando) 33, no. 3 (July 2019): 115–29. https://doi.org/10.1016/j.trre.2019.03.002.

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Schmitz, R., M. S. Mulvihill, P. M. Schroder, Z. Fitch, F. Leopardi, D. Magnani, J. Kwun, S. J. Knechtle, and A. D. Kirk. “Depletional Induction Therapy in Non-Human Primates - Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG..” In American Journal of Transplantation, 19:597–597. WILEY, 2019.

Scholars@Duke

Schroder, P. M., R. Schmitz, Z. Fitch, B. Ezekian, J. Yoon, A. Choi, A. Barbas, et al. “Dual Targeting Desensitization with Carfilzomib Plus Lulizumab Significantly Prolongs Kidney Transplant Survival in Allosensitized Nonhuman Primates..” In American Journal of Transplantation, 19:429–429. WILEY, 2019.

Scholars@Duke

Schroder, P., J. Yoon, R. Schmitz, Z. Fitch, J. Kwun, and S. J. Knechtle. “Novel In Vitro Germinal Center Culture System Demonstrates More Aggressive B Cell to Plasma Blast Differentiation in Allosensitized Nonhuman Primates..” In American Journal of Transplantation, 19:1090–1090. WILEY, 2019.

Scholars@Duke

Schroder, P., J. S. Yi, K. J. Weinhold, C. Chan, M. Joshi, C. Walters, J. Kwun, and S. J. Knechtle. “Pre-Transplant Multidimensional Flow Cytometric Analysis of Kidney Transplant Recipients Reveals Novel Immune Signature of Allograft Rejection..” In American Journal of Transplantation, 19:765–66. WILEY, 2019.

Scholars@Duke

Berger, Miles, Deborah Oyeyemi, Mobolaji O. Olurinde, Heather E. Whitson, Kent J. Weinhold, Marty G. Woldorff, Lewis A. Lipsitz, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction..” J Am Geriatr Soc 67, no. 4 (April 2019): 794–98. https://doi.org/10.1111/jgs.15770.

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Burghuber, Christopher K., Miriam Manook, Brian Ezekian, Adriana C. Gibby, Frank V. Leopardi, Minqing Song, Jennifer Jenks, et al. “Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients..” Am J Transplant 19, no. 3 (March 2019): 724–36. https://doi.org/10.1111/ajt.15067.

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Moris, Dimitrios, Ioannis D. Kostakis, Nikolaos Machairas, Anastasia Prodromidou, Diamantis I. Tsilimigras, Kadiyala V. Ravindra, Debra L. Sudan, Stuart J. Knechtle, and Andrew S. Barbas. “Comparison between liver transplantation and resection for hilar cholangiocarcinoma: A systematic review and meta-analysis..” Plos One 14, no. 7 (2019). https://doi.org/10.1371/journal.pone.0220527.

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Ezekian, Brian, Michael S. Mulvihill, Paul M. Schroder, Brian F. Gilmore, Harold J. Leraas, Brian C. Gulack, Sarah Jane Commander, et al. “Improved contemporary outcomes of liver transplantation for pediatric hepatoblastoma and hepatocellular carcinoma..” Pediatric Transplantation 22, no. 8 (December 2018). https://doi.org/10.1111/petr.13305.

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