
During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects. These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses. During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients. This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways. The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance. My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.
Recent Publications
Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text
Education and Training
- Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
- Residency, Surgery, Duke University School of Medicine, 1982 - 1989
- M.D., Cornell University, Weill Medical College, 1982
In the News
Selected Grants
- Targeting the B Cell Response to Treat Antibody-Mediated Rejection
- AlloVir P105-401 Registry
- Allo Vir ALVR105
- IMAGINE
- Targeting mitochondrial dysfunction and damage-associated molecular patterns to improve the function of high risk grafts in liver transplantation
- IM101-823 - Abatacept for treatment of recurrent or de novo autoimmune hepatitis
- EVALUATION OF PATIENT OUTCOMES FROM THE KIDNEY ALLOGRAFT OUTCOMES ALLOSURE REGISTRY (KOAR) AGREEMENT
- Targeting complement C3 to prevent acute antibody-mediated rejection for a deceased-donor kidney transplant in sensitized recipients
- Developing clinically relevant immunosuppressive regimen for pig to rhesus kidney transplantation using transgenic pigs
- Duke CTSA (TL1) Year 5
- Novel development ofan acoustofluidic device for targeted antibody removal in pediatric organ transplan rejection
- Acoustic Device to Prevent Antibody Mediated Organ Transplant Failure
- LET vs VGCV for Prevention of CMV disease in Kidney Transplant Recipients
- ITN089ST (ADAPT) - Measuring Allospecific Impact Of Belatacept/Carfilzomib Desensitization
- ITN336 Immune Tolerance Network
- Alexion Sponsored Research Agreement
- Duke Resident Physician-Scientist Program - NIAID
- The Risks and Opporunities of Homeostatic Repopulation
- Duke Resident Physician-Scientist Program- NHLBI
- Measuring the Impact of Allosensitization on Xenotransplantation
- Acoustic based plasmapheresis to prevent antibody-mediated organ transplant
- Lung Transplant Plasmapheresis (PLEX)/Belatacept/Carfilzomib Protocol for Treatment of Antibody Mediated Rejection (AMR) and Desensitization
- ASTS Presidential Student Mentor Grant
- Transplant Tolerance in Non-Human Primates
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel
- Visiting Research Fellowship
- Prevention of Homograft Induced Cardiac Allograft Vasculopathy in Pediatric Heart Transplantation
- Preventing allograft rejection but not tolerance by blockade of the lymphocyte store-operated calcium channel
- Inducible Regulatory B Cells in Transplantation Tolerance