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Stuart Johnston Knechtle, MD

Mary and Deryl Hart Professor of Surgery, in the School of Medicine
Professor of Surgery

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients. 

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin at Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Weill Cornell Medical College, 1982

Publications

Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Yoon, J, Yi, JS, Iwakoshi, N, Gibby, A, Hong, JJ, Farris, AB, Kirk, AD, and Knechtle, SJ. "Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates." Blood advances 1, no. 24 (November 2017): 2115-2119.

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Ezekian, B, Mulvihill, MS, Freischlag, K, Yerokun, BA, Davis, RP, Hartwig, MG, Knechtle, SJ, and Barbas, AS. "Elevated HbA1c in donor organs from patients without a diagnosis of diabetes portends worse liver allograft survival." Clinical transplantation 31, no. 9 (September 2017).

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Dendy, MS, Camacho, JC, Ludwig, JM, Krasinskas, AM, Knechtle, SJ, and Kim, HS. "Infiltrative Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Treated With a Single High-Dose Y90 Radioembolization and Subsequent Liver Transplantation Without a Recurrence." Transplantation direct 3, no. 9 (September 2017): e206-.

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Manook, M, Kwun, J, Burghuber, C, Samy, K, Mulvihill, M, Yoon, J, Xu, H, MacDonald, AL, Freischlag, K, Curfman, V, Branum, E, Howell, D, Farris, AB, Smith, RA, Sacks, S, Dorling, A, Mamode, N, and Knechtle, SJ. "Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 8 (August 2017): 2055-2064.

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Barbas, AS, Dib, MJ, Rege, AS, Vikraman, DS, Sudan, DL, Knechtle, SJ, and Scarborough, JE. "The Volume-outcome Relationship in Deceased Donor Kidney Transplantation and Implications for Regionalization." Annals of surgery (July 22, 2017).

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Kwun, J, Burghuber, C, Manook, M, Iwakoshi, N, Gibby, A, Hong, JJ, and Knechtle, S. "Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients." Journal of the American Society of Nephrology : JASN 28, no. 7 (July 2017): 1991-1996.

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Kwun, J, Manook, M, Page, E, Burghuber, C, Hong, J, and Knechtle, SJ. "Crosstalk Between T and B Cells in the Germinal Center After Transplantation." Transplantation 101, no. 4 (April 2017): 704-712. (Review)

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Xing, M, Sakaria, S, Dhanasekaran, R, Parekh, S, Spivey, J, Knechtle, SJ, Zhang, D, and Kim, HS. "Bridging Locoregional Therapy Prolongs Survival in Patients Listed for Liver Transplant with Hepatocellular Carcinoma." Cardiovascular and interventional radiology 40, no. 3 (March 2017): 410-420.

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Schadde, E, Tsatsaris, C, Swiderska-Syn, M, Breitenstein, S, Urner, M, Schimmer, R, Booy, C, Z'graggen, BR, Wenger, RH, Spahn, DR, Hertl, M, Knechtle, S, Diehl, AM, Schläpfer, M, and Beck-Schimmer, B. "Hypoxia of the growing liver accelerates regeneration." Surgery 161, no. 3 (March 2017): 666-679.

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Schroder, PM, Ezekian, B, Ford, M, Knechtle, SJ, and Kwun, J. "Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation." Frontiers in immunology 8 (January 2017): 1615-.

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