
Dr. Smith is the Prinicpal Investigator for the Duke site in the Cardiothoracic Surgery Clinical Trials Network (CTSN) and in recent years has focused his research efforts in clinical research. The CTSN is an NHLBI sponsored network developed to promote clinical research in cardiac surgery, and is now entering its 7th year of funding with a commitment now for an additional 5 years. Dr. Smith is the national PI for a randomized clinical trial comparing CABG alone to CABG with mitral repair for moderate ischemic mitral regurgitation. This trial is nearing completion of enrollment, and he is now the PI of a clinical trial of FFR vs angiographically guided CABG expected to begin national enrollment in September of 2013. Duke has participated as a site in 3 additional CTSN trials, and is one of two sites awarded NHLBI funding as a Clinical Skills Education Core. This funding is designed to formally develop surgical clinical trialists and promote clinical research capacity within our specialty. The Duke site has thus far sponsored 6 CTSN scholars who have all received Masters degrees in clinical research, participated in CTSN protocols and other activities of the Network. Additionally, Dr. Smith has been awarded site funding from the Veteran’s Administration to begin VA cooperative clinical research trials at the Durham VA. Through all of these activities, an integration of clinical research, publications, and scholarship with the advancement of clinically effective Thoracic Surgery is the goal.
Education and Training
- M.D., Duke University, 1977
In the News
Selected Grants
- Postdoctoral Training in Cardiovascular Clinical Research
- Duke Resident Physician-Scientist Program- NHLBI
- Cardiothoracic Surgical Trials Network
MESENCHYMAL STEM CELLS FOR THE TREATMENT OF MODERATE TO SEVERE COVID-19 ACUTE RESPIRATORY DISTRESS SYNDROME - A Multicenter, Adaptive, Randomized, Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients with COVID-19
- Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine: ¿Mesenchymal Stem Cells for the Treatment of Moderate to Severe COVID-19 Acute Respiratory Distress Syndrome
- : Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine: ¿Long-Term Follow-Up for Participants of MMR and SMR Trials
- Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine: ¿Anticoagulation for New-Onset Post-Operative
- Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine: ¿Evaluating the Benefit Of Concurrent Tricupsid Valve Repair During Mitral Surgery¿
- IPA for Melissa Wagner
- Hybrid Coronary Revascularization Trial- DCC
- Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine
- Evaluating the Benefit Of Concurrent Tricupsid Valve Repair During Mitral Surgery
- IPA for Shannon Griffin
- Core Clinical Centers for the CTSN
- PeriOperative Interventional Neuroprotection Trial POINT
- Coronary Insufficiency & Myocardical Revascularization
- Coronary Insufficiency & Myocardial Revascularization
- Atrioventricular Interactions Related To Cardiac Surgery
- Atrioventricular Interactions In Cardiac Surgery