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Peter Kent Smith, MD

Mary and Deryl Hart Distinguished Professor of Surgery, in the School of Medicine
Professor of Surgery
Office: 8660 Hafs Building, Durham, NC 27710
Campus Mail: DUMC Box 3442 Med Ctr, Durham, NC 27710

Dr. Smith is the Prinicpal Investigator for the Duke site in the Cardiothoracic Surgery Clinical Trials Network (CTSN) and in recent years has focused his research efforts in clinical research. The CTSN is an NHLBI sponsored network developed to promote clinical research in cardiac surgery, and is now entering its 7th year of funding with a commitment now for an additional 5 years. Dr. Smith is the national PI for a randomized clinical trial comparing CABG alone to CABG with mitral repair for moderate ischemic mitral regurgitation. This trial is nearing completion of enrollment, and he is now the PI of a clinical trial of FFR vs angiographically guided CABG expected to begin national enrollment in September of 2013. Duke has participated as a site in 3 additional CTSN trials, and is one of two sites awarded NHLBI funding as a Clinical Skills Education Core. This funding is designed to formally develop surgical clinical trialists and promote clinical research capacity within our specialty. The Duke site has thus far sponsored 6 CTSN scholars who have all received Masters degrees in clinical research, participated in CTSN protocols and other activities of the Network. Additionally, Dr. Smith has been awarded site funding from the Veteran’s Administration to begin VA cooperative clinical research trials at the Durham VA. Through all of these activities, an integration of clinical research, publications, and scholarship with the advancement of clinically effective Thoracic Surgery is the goal.

Education and Training

  • M.D., Duke University, 1977

Selected Grants

Publications

Bagiella, Emilia, John D. Puskas, Alan J. Moskowitz, Annetine C. Gelijns, John H. Alexander, Jagat Narula, Peter K. Smith, et al. “Rationale and design of a randomized trial evaluating an external support device for saphenous vein coronary grafts.” Am Heart J 246 (April 2022): 12–20. https://doi.org/10.1016/j.ahj.2021.12.009.

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Messé, Steven R., Jessica R. Overbey, Vinod H. Thourani, Alan J. Moskowitz, Annetine C. Gelijns, Mark A. Groh, Michael J. Mack, et al. “The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement.” J Thorac Cardiovasc Surg, March 18, 2022. https://doi.org/10.1016/j.jtcvs.2022.01.053.

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Doenst, Torsten, Haissam Haddad, Amanda Stebbins, James A. Hill, Eric J. Velazquez, Kerry L. Lee, Jean L. Rouleau, et al. “Renal function and coronary bypass surgery in patients with ischemic heart failure.” J Thorac Cardiovasc Surg 163, no. 2 (February 2022): 663-672.e3. https://doi.org/10.1016/j.jtcvs.2020.02.136.

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Sabatine, Marc S., Brian A. Bergmark, Sabina A. Murphy, Patrick T. O’Gara, Peter K. Smith, Patrick W. Serruys, A Pieter Kappetein, et al. “Percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis.” Lancet 398, no. 10318 (December 18, 2021): 2247–57. https://doi.org/10.1016/S0140-6736(21)02334-5.

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Lala, Anuradha, Helena L. Chang, Xiaoyu Liu, Eric J. Charles, Babatunde A. Yerokun, Michael E. Bowdish, Vinod H. Thourani, et al. “Risk for non-home discharge following surgery for ischemic mitral valve disease.” J Thorac Cardiovasc Surg 162, no. 6 (December 2021): 1769-1778.e7. https://doi.org/10.1016/j.jtcvs.2020.02.084.

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Baker, Arthur W., Eileen K. Maziarz, Sarah S. Lewis, Jason E. Stout, Deverick J. Anderson, Peter K. Smith, Jacob N. Schroder, et al. “Invasive Mycobacterium abscessus Complex Infection After Cardiac Surgery: Epidemiology, Management, and Clinical Outcomes.” Clin Infect Dis 72, no. 7 (April 8, 2021): 1232–40. https://doi.org/10.1093/cid/ciaa215.

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Bertrand, Philippe B., Jessica R. Overbey, Xin Zeng, Robert A. Levine, Gorav Ailawadi, Michael A. Acker, Peter K. Smith, et al. “Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation.” J Am Coll Cardiol 77, no. 6 (February 16, 2021): 713–24. https://doi.org/10.1016/j.jacc.2020.11.066.

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Alexander, John H., and Peter K. Smith. “Are We At Risk of Depriving Patients Lifesaving Cardiac Surgery?: Implications of the ISCHEMIA Trial for Coronary Artery Bypass Graft Surgery.” Circulation 142, no. 19 (November 10, 2020): 1797–98. https://doi.org/10.1161/CIRCULATIONAHA.120.050524.

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Ferket, Bart S., Vinod H. Thourani, Pierre Voisine, Samuel F. Hohmann, Helena L. Chang, Peter K. Smith, Robert E. Michler, et al. “Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation.” J Thorac Cardiovasc Surg 159, no. 6 (June 2020): 2230-2240.e15. https://doi.org/10.1016/j.jtcvs.2019.06.040.

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Jawitz, Oliver K., Brian C. Gulack, J Matthew Brennan, Dylan P. Thibault, Alice Wang, Sean M. O’Brien, Jacob N. Schroder, Jeffrey G. Gaca, and Peter K. Smith. “Association of postoperative complications and outcomes following coronary artery bypass grafting.” Am Heart J 222 (April 2020): 220–28. https://doi.org/10.1016/j.ahj.2020.02.002.

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