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Jean Kwun, PhD

Assistant Professor in Surgery
Office: 362 Jones Building, 207 Research Dr, Durham, NC 27710

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 2007

Publications

Manook, M., J. Kwun, J. Yoon, K. Samy, A. MacDonlad, H. Xu, R. Smith, et al. “Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.” In American Journal of Transplantation, 17:212–212. WILEY, 2017.

Scholars@Duke

Lee, Jaewoo, Jennifer G. Jackman, Jean Kwun, Miriam Manook, Angelo Moreno, Eric A. Elster, Allan D. Kirk, Kam W. Leong, and Bruce A. Sullenger. “Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis.” Biomaterials 120 (March 2017): 94–102. https://doi.org/10.1016/j.biomaterials.2016.12.024.

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Schroder, Paul M., Brian Ezekian, Mandy Ford, Stuart J. Knechtle, and Jean Kwun. “Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.” Front Immunol 8 (2017): 1615. https://doi.org/10.3389/fimmu.2017.01615.

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George, Roshan P., Aneesh K. Mehta, Sebastian D. Perez, Pamela Winterberg, Jennifer Cheeseman, Brandi Johnson, Jean Kwun, et al. “Premature T Cell Senescence in Pediatric CKD.” J Am Soc Nephrol 28, no. 1 (January 2017): 359–67. https://doi.org/10.1681/ASN.2016010053.

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Oh, B., J. Yoon, A. Farris, A. Kirk, S. Knechtle, and J. Kwun. “Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.” Am J Transplant 16, no. 9 (September 2016): 2612–23. https://doi.org/10.1111/ajt.13789.

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Burghuber, C. K., J. Kwun, E. J. Page, M. Manook, A. C. Gibby, F. V. Leopardi, M. Song, et al. “Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.” Am J Transplant 16, no. 6 (June 2016): 1726–38. https://doi.org/10.1111/ajt.13688.

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Kwun, J., C. Burghuber, N. Iwakoshi, A. Gibby, and S. Knechtle. “Limited Efficacy of Bortezomib on Desensitization via Rapid Humoral Compensation in a Sensitized Rhesus Model.” In American Journal of Transplantation, 16:406–406. WILEY-BLACKWELL, 2016.

Scholars@Duke

Manook, M., J. Kwun, J. Yoon, S. Sacks, A. Dorling, N. Mamode, R. Smith, and S. Knechtle. “Thrombalexin: Detection & Efficacy of a Membrane-Bound Anti-Thrombin Agent.” In American Journal of Transplantation, 16:719–20. WILEY-BLACKWELL, 2016.

Scholars@Duke

Kwun, J., C. Burghuber, M. Manook, A. Clark, D. Chen, and S. Knechtle. “Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model.” In American Journal of Transplantation, 16:410–410. WILEY-BLACKWELL, 2016.

Scholars@Duke

Kwun, Jean, Alton B. Farris, Hyunjin Song, William T. Mahle, William J. Burlingham, and Stuart J. Knechtle. “Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.” Transplantation 99, no. 12 (December 2015): 2485–93. https://doi.org/10.1097/TP.0000000000000805.

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