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Herbert Kim Lyerly, MD

George Barth Geller Distinguished Professor of Immunology
Professor of Surgery
Professor in Immunology
Professor of Pathology
Office: 203 Research Drive, Rm 433B, Box 2606, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Education and Training

  • M.D., University of California - Los Angeles, 1983

Selected Grants

Publications

Osada, Takuya, Sandip P. Patel, Scott A. Hammond, Koya Osada, Michael A. Morse, and H Kim Lyerly. “CEA/CD3-bispecific T cell-engaging (BiTE) antibody-mediated T lymphocyte cytotoxicity maximized by inhibition of both PD1 and PD-L1.” Cancer Immunol Immunother 64, no. 6 (June 2015): 677–88. https://doi.org/10.1007/s00262-015-1671-y.

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Kravchenko, Julia, Emanuela Corsini, Marc A. Williams, William Decker, Masoud H. Manjili, Takemi Otsuki, Neetu Singh, et al. “Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions.” Carcinogenesis 36 Suppl 1 (June 2015): S111–27. https://doi.org/10.1093/carcin/bgv033.

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Das Roy, Lopamudra, Ru Zhou, Laura Jeffords Moore, Lloye M. Dillon, Rahul Puri, Kim Lyerly, Jeffrey R. Marks, and Pinku Mukherjee. “Early detection of breast cancer using a unique tumor specific antibody.” In Journal of Clinical Oncology, Vol. 33. AMER SOC CLINICAL ONCOLOGY, 2015.

Scholars@Duke

Gwin, William Rayford, Amy Hobeika, Takuya Osada, Zachary Hartman, Qing Cheng, Gloria Broadwater, Gretchen Genevieve Kimmick, Kimberly L. Blackwell, Michael Morse, and Kim Lyerly. “Effect of alphavirus vaccine encoding HER2 during concurrent anti-HER2 therapies on induction of oligoclonal T cell and antibody responses against HER2.” In Journal of Clinical Oncology, 33:3081–3081. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.3081.

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Osada, Takuya, Koji Nagaoka, Masashi Takahara, Xiao Yi Yang, Cong-Xiao Liu, Hongtao Guo, Kingshuk Roy Choudhury, et al. “Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors.” J Immunother 38, no. 4 (May 2015): 155–64. https://doi.org/10.1097/CJI.0000000000000075.

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Lyerly, H Kim, Maria R. Fawzy, Zeba Aziz, Reena Nair, C. S. Pramesh, Vani Parmar, Purvish M. Parikh, et al. “Regional variation in identified cancer care needs of early-career oncologists in China, India, and Pakistan.” Oncologist 20, no. 5 (May 2015): 532–38. https://doi.org/10.1634/theoncologist.2014-0213.

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Kravchenko, Julia, Mark Berry, Konstantin Arbeev, H Kim Lyerly, Anatoly Yashin, and Igor Akushevich. “Cardiovascular comorbidities and survival of lung cancer patients: Medicare data based analysis.” Lung Cancer 88, no. 1 (April 2015): 85–93. https://doi.org/10.1016/j.lungcan.2015.01.006.

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Snyder, Joshua C., Lauren K. Rochelle, Sébastien Marion, H Kim Lyerly, Larry S. Barak, and Marc G. Caron. “Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.” J Cell Sci 128, no. 6 (March 15, 2015): 1230–40. https://doi.org/10.1242/jcs.166322.

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Ren, Xiu-Rong, Jiangbo Wang, Takuya Osada, Robert A. Mook, Michael A. Morse, Larry S. Barak, Herbert Kim Lyerly, and Wei Chen. “Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.” Breast Cancer Res 17 (February 15, 2015): 20. https://doi.org/10.1186/s13058-015-0528-9.

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Zhao, Yan-Jie, Ni Jiang, Qing-Kun Song, Jiang-Ping Wu, Yu-Guang Song, Hong-Mei Zhang, Feng Chen, et al. “Continuous DC-CIK infusions restore CD8+ cellular immunity, physical activity and improve clinical efficacy in advanced cancer patients unresponsive to conventional treatments.” Asian Pac J Cancer Prev 16, no. 6 (2015): 2419–23. https://doi.org/10.7314/apjcp.2015.16.6.2419.

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