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Guido Ferrari, MD

Guido Ferrari, MD
Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Division: 
Surgical Sciences
Faculty Lab: 
Innate and Adaptive Cellular Cytotoxicity Laboratory
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

In the News

Selected Grants

Publications

Ferrari, Guido, Jeffrey Nordstrom, Scott Koenig, Julia Sung, David Margolis, and Barton Haynes. “A-102 Antibody binding to HIV-1 infected cells as mechanism for treatment of HIV infection.” In Jaids Journal of Acquired Immune Deficiency Syndromes, 77:33–33. Ovid Technologies (Wolters Kluwer Health), 2018. https://doi.org/10.1097/01.qai.0000532483.69631.d6.

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Pollara, Justin, Chiara Orlandi, Charles Beck, R Whitney Edwards, Yi Hu, Shuying Liu, Shixia Wang, et al. “Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay..” Cytometry A 93, no. 4 (April 2018): 436–47. https://doi.org/10.1002/cyto.a.23348.

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Wills, Saintedym, Kwan-Ki Hwang, Pinghuang Liu, S Moses Dennison, Matthew Zirui Tay, Xiaoying Shen, Justin Pollara, et al. “HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis..” J Virol 92, no. 7 (April 1, 2018). https://doi.org/10.1128/JVI.01552-17.

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Fong, Youyi, Xiaoying Shen, Vicki C. Ashley, Aaron Deal, Kelly E. Seaton, Chenchen Yu, Shannon P. Grant, et al. “Modification of the Association Between T-Cell Immune Responses and Human Immunodeficiency Virus Type 1 Infection Risk by Vaccine-Induced Antibody Responses in the HVTN 505 Trial..” J Infect Dis 217, no. 8 (March 28, 2018): 1280–88. https://doi.org/10.1093/infdis/jiy008.

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Francica, J. R., D. E. Zak, C. Linde, E. Siena, C. Johnson, M. Juraska, N. L. Yates, et al. “Erratum: Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs (Blood Advances (2017) 1:25 (2329-2342) DOI: 10.1182/bloodadvances.2017011411).” Blood Advances 2, no. 5 (March 13, 2018). https://doi.org/10.1182/bloodadvances.2018017491.

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Jones, Andrew T., Venkateswarlu Chamcha, Sannula Kesavardhana, Xiaoying Shen, David Beaumont, Raksha Das, Linda S. Wyatt, et al. “A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques..” J Virol 92, no. 5 (March 1, 2018). https://doi.org/10.1128/JVI.01796-17.

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Viegas, Edna Omar, Nelson Tembe, Charlotta Nilsson, Bindiya Meggi, Cremildo Maueia, Orvalho Augusto, Richard Stout, et al. “Intradermal HIV-1 DNA Immunization Using Needle-Free Zetajet Injection Followed by HIV-Modified Vaccinia Virus Ankara Vaccination Is Safe and Immunogenic in Mozambican Young Adults: A Phase I Randomized Controlled Trial..” Aids Res Hum Retroviruses 34, no. 2 (February 2018): 193–205. https://doi.org/10.1089/AID.2017.0121.

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Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells..” Commun Biol 1 (2018). https://doi.org/10.1038/s42003-018-0131-6.

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Eudailey, Joshua A., Maria L. Dennis, Morgan E. Parker, Bonnie L. Phillips, Tori N. Huffman, Camden P. Bay, Michael G. Hudgens, et al. “Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques..” Msphere 3, no. 1 (January 2018). https://doi.org/10.1128/mSphere.00505-17.

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Shen, Xiaoying, Rahul Basu, Sheetal Sawant, David Beaumont, Sue Fen Kwa, Celia LaBranche, Kelly E. Seaton, et al. “HIV-1 gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine..” J Virol 91, no. 24 (December 15, 2017). https://doi.org/10.1128/JVI.01077-17.

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