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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Division: 
Surgical Sciences
Faculty Lab: 
Innate and Adaptive Cellular Cytotoxicity Laboratory
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

In the News

Selected Grants

Publications

Francica, Joseph R., Daniel E. Zak, Caitlyn Linde, Emilio Siena, Carrie Johnson, Michal Juraska, Nicole L. Yates, et al. “Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs..” Blood Adv 1, no. 25 (November 28, 2017): 2329–42. https://doi.org/10.1182/bloodadvances.2017011411.

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Mayer, Kenneth H., Kelly E. Seaton, Yunda Huang, Nicole Grunenberg, Abby Isaacs, Mary Allen, Julie E. Ledgerwood, et al. “Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial..” Plos Med 14, no. 11 (November 2017). https://doi.org/10.1371/journal.pmed.1002435.

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Liu, Donglai, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, et al. “A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies..” Retrovirology 14, no. 1 (October 10, 2017). https://doi.org/10.1186/s12977-017-0371-4.

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Shen, Xiaoying, Willy M. Bogers, Nicole L. Yates, Guido Ferrari, Antu K. Dey, William T. Williams, Frederick H. Jaeger, et al. “Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques..” J Virol 91, no. 19 (October 1, 2017). https://doi.org/10.1128/JVI.00401-17.

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Phillips, Bonnie, Genevieve G. Fouda, Josh Eudailey, Justin Pollara, Alan D. Curtis, Erika Kunz, Maria Dennis, et al. “Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques..” Clin Vaccine Immunol 24, no. 10 (October 2017). https://doi.org/10.1128/CVI.00231-17.

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Bogers, Willy M. J. M., Susan W. Barnett, Herman Oostermeijer, Ivonne G. Nieuwenhuis, Niels Beenhakker, Daniella Mortier, Petra Mooij, et al. “Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site..” J Virol 91, no. 19 (October 1, 2017). https://doi.org/10.1128/JVI.00811-17.

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Lewis, George K., Marzena Pazgier, David T. Evans, Guido Ferrari, Stylianos Bournazos, Matthew S. Parsons, Nicole F. Bernard, and Andrés Finzi. “Beyond Viral Neutralization..” Aids Res Hum Retroviruses 33, no. 8 (August 2017): 760–64. https://doi.org/10.1089/AID.2016.0299.

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Meyerhoff, R Ryan, Richard M. Scearce, Damon F. Ogburn, Brad Lockwood, Joy Pickeral, Masa Kuraoka, Kara Anasti, et al. “HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies..” Aids Res Hum Retroviruses 33, no. 8 (August 2017): 859–68. https://doi.org/10.1089/AID.2016.0294.

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Joachim, Agricola, Patricia J. Munseri, Charlotta Nilsson, Muhammad Bakari, Said Aboud, Eligius F. Lyamuya, Teghesti Tecleab, et al. “Three-Year Durability of Immune Responses Induced by HIV-DNA and HIV-Modified Vaccinia Virus Ankara and Effect of a Late HIV-Modified Vaccinia Virus Ankara Boost in Tanzanian Volunteers..” Aids Res Hum Retroviruses 33, no. 8 (August 2017): 880–88. https://doi.org/10.1089/AID.2016.0251.

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Bradley, Todd, Justin Pollara, Sampa Santra, Nathan Vandergrift, Srivamshi Pittala, Chris Bailey-Kellogg, Xiaoying Shen, et al. “Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge..” Nat Commun 8 (June 8, 2017). https://doi.org/10.1038/ncomms15711.

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