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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Tomaras, G. D., S. F. Lacey, C. B. McDanal, G. Ferrari, K. J. Weinhold, and M. L. Greenberg. “CD8+ T cell-mediated suppressive activity inhibits HIV-1 after virus entry with kinetics indicating effects on virus gene expression..” Proc Natl Acad Sci U S A 97, no. 7 (March 28, 2000): 3503–8. https://doi.org/10.1073/pnas.070521097.

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Markert, M. L., C. B. Hicks, J. A. Bartlett, J. L. Harmon, L. P. Hale, M. L. Greenberg, G. Ferrari, et al. “Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection..” Aids Res Hum Retroviruses 16, no. 5 (March 20, 2000): 403–13. https://doi.org/10.1089/088922200309061.

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Falk, Lydia A., Karen L. Goldenthal, Jose Esparza, M Teresa Aguado, Saladin Osmanov, and W Ripley Ballou. “Recombinant Bacillus Calmette-Guerin as a Potential Vector for Preventive HIV Type 1 Vaccines.” Aids Research and Human Retroviruses 16, no. 2 (January 20, 2000): 91–98. https://doi.org/10.1089/088922200309421.

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Demarest, J. F., S. B. Jones, G. Ferrari, C. J. Johnson, M. Greenberg, T. O. O’Brien, W. Blattner, et al. “Natural history of HIV-specific CTL activity during acute HIV infection: envelope CTL impact subsequent plasma viremia..” In Faseb Journal, 13:A294–A294. FEDERATION AMER SOC EXP BIOL, 1999.

Scholars@Duke

Stranford, S. A., J. Skurnick, D. Louria, D. Osmond, S. Y. Chang, J. Sninsky, G. Ferrari, K. Weinhold, C. Lindquist, and J. A. Levy. “Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response..” Proc Natl Acad Sci U S A 96, no. 3 (February 2, 1999): 1030–35. https://doi.org/10.1073/pnas.96.3.1030.

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Weinhold, K. J., W. Humphrey, K. Corr, J. Johnson, M. West, C. Wiggins, S. Jones, J. Ottinger, M. Blanks, and G. Ferrari. “Cellular immune responses to candidate AIDS vaccines.” In 11e Colloque Des Cent Gardes, edited by M. Girard and B. Dodet, 167–75. EDITIONS SCIENTIFIQUES ET MEDICALES ELSEVIER, 1998.

Scholars@Duke

Stranford, S., J. Skurnick, D. Louria, D. Osmond, S. Y. Chang, J. Sninsky, G. Ferrari, K. Weinhold, C. Lindquist, and J. Levy. “The CD8+ cell non-cytotoxic, anti-HIV response is associated with protection in HIV-exposed, uninfected individuals.” In Faseb Journal, Vol. 12, 1998.

Scholars@Duke

Ferrari, G., C. Berend, J. Ottinger, R. Dodge, J. Bartlett, J. Toso, D. Moody, et al. “Replication-defective canarypox (ALVAC) vectors effectively activate anti-human immunodeficiency virus-1 cytotoxic T lymphocytes present in infected patients: implications for antigen-specific immunotherapy..” Blood 90, no. 6 (September 15, 1997): 2406–16.

Scholars@Duke

Ferrari, G., W. Humphrey, M. J. McElrath, J. L. Excler, A. M. Duliege, M. L. Clements, L. C. Corey, D. P. Bolognesi, and K. J. Weinhold. “Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers..” Proc Natl Acad Sci U S A 94, no. 4 (February 18, 1997): 1396–1401. https://doi.org/10.1073/pnas.94.4.1396.

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Laughlin, M. J., J. Kurtzberg, K. Weinhold, G. Ferrari, A. Pilgrim, C. Gelber, S. Nair, et al. “Generation of T lymphocyte clones specific for acute lymphoblastic leukemia (ALL) via dendritic cell (DC) presentation..” In Blood, 88:1487–1487. W B SAUNDERS CO, 1996.

Scholars@Duke

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