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Gayathri R. Devi, PhD

Associate Director, Research Education
Associate Professor in Surgery
Associate Professor in Pathology
Office: 477 Med.Sci.Res.Bldg. (Msrb1), 2606 DUMC, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Dr. Devi’s research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer.

The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models.

Education and Training

  • Ph.D., University of Nebraska College of Medicine, 1998

Publications

Ding, X., A. B. Mohd, Z. Huang, T. Baba, M. Q. Bernardini, H. K. Lyerly, A. Berchuck, S. K. Murphy, A. B. Buermeyer, and G. R. Devi. “MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition..” Br J Cancer 101, no. 2 (July 21, 2009): 269–77. https://doi.org/10.1038/sj.bjc.6605180.

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Mavropoulos, John C., W Cooper Buschemeyer, Alok K. Tewari, Dmitriy Rokhfeld, Michael Pollak, Yunhua Zhao, Phillip G. Febbo, et al. “The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model..” Cancer Prev Res (Phila) 2, no. 6 (June 2009): 557–65. https://doi.org/10.1158/1940-6207.CAPR-08-0188.

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Sekhon, Harmanjatinder S., Carla A. London, Mypinder Sekhon, Patrick L. Iversen, and Gayathri R. Devi. “c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model..” Lung Cancer 60, no. 3 (June 2008): 347–54. https://doi.org/10.1016/j.lungcan.2007.10.028.

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Aird, Katherine M., Xiuyun Ding, Aris Baras, Junping Wei, Michael A. Morse, Timothy Clay, Herbert K. Lyerly, and Gayathri R. Devi. “Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression..” Mol Cancer Ther 7, no. 1 (January 2008): 38–47. https://doi.org/10.1158/1535-7163.MCT-07-0370.

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Morse, Michael A., Amy Hobeika, Takuya Osada, Donna Niedzwiecki, Paul Kelly Marcom, Kimberly L. Blackwell, Carey Anders, Gayathri R. Devi, H Kim Lyerly, and Timothy M. Clay. “Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2..” J Transl Med 5 (September 6, 2007). https://doi.org/10.1186/1479-5876-5-42.

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Baras, Aris I., Ian Cushman, Yiting Cao, Herbert K. Lyerly, Mark Dewhirst, Patrick Casey, and Gayathri R. Devi. “Development of cellular models and small GTPases-targeted therapeutics for inflammatory breast cancer.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.

Scholars@Duke

Devi, Gayathri R., Tomasz M. Beer, Christopher L. Corless, Vikram Arora, Doreen L. Weller, and Patrick L. Iversen. “In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors..” Clin Cancer Res 11, no. 10 (May 15, 2005): 3930–38. https://doi.org/10.1158/1078-0432.CCR-04-2091.

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Devi, G. R. “Genomics-based anti-cancer drug discovery - Preface.” Current Pharmaceutical Biotechnology. BENTHAM SCIENCE PUBL LTD, October 1, 2004.

Scholars@Duke

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