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Gayathri R. Devi, PhD

Associate Director, Research Education
Associate Professor in Surgery
Associate Professor in Pathology
Office: 477 Med.Sci.Res.Bldg. (Msrb1), 2606 DUMC, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Dr. Devi’s research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer.

The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models.

Education and Training

  • Ph.D., University of Nebraska College of Medicine, 1998

Publications

Bocci, F, Gearhart-Serna, L, Boareto, M, Ribeiro, M, Ben-Jacob, E, Devi, GR, Levine, H, Onuchic, JN, and Jolly, MK. "Toward understanding cancer stem cell heterogeneity in the tumor microenvironment." Proceedings of the National Academy of Sciences of the United States of America 116, no. 1 (January 2019): 148-157.

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Oladapo, H, Ji, X, Shehata, H, Tarpley, M, Chdid, L, Lamson, D, Bao, X, Sauer, S, Devi, GR, and Williams, KP. "Efficacy of GLI antagonists in triple-negative inflammatory breast cancer 2D and 3D models." 10th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. Atlanta, GA. September 25, 2017 - September 28, 2017.: AMER ASSOC CANCER RESEARCH, July 1, 2018.

Scholars@Duke

Samy, KP, Davis, RP, Gao, Q, Martin, BM, Song, M, Cano, J, Farris, AB, McDonald, A, Gall, EK, Dove, CR, Leopardi, FV, How, T, Williams, KD, Devi, GR, Collins, BH, and Kirk, AD. "Early barriers to neonatal porcine islet engraftment in a dual transplant model." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 18, no. 4 (April 2018): 998-1006.

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Evans, MK, Brown, MC, Geradts, J, Bao, X, Robinson, TJ, Jolly, MK, Vermeulen, PB, Palmer, GM, Gromeier, M, Levine, H, Morse, MA, Van Laere, SJ, and Devi, GR. "XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype." Cancer Research 78, no. 7 (April 2018): 1726-1738.

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Gearhart-Serna, LM, Jayasundara, N, Tacam, M, Di Giulio, R, and Devi, GR. "Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations." Journal of Environmental and Public Health 2018 (January 2018): 5610462-null.

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Oladapo, HO, Tarpley, M, Sauer, SJ, Addo, KA, Ingram, SM, Strepay, D, Ehe, BK, Chdid, L, Trinkler, M, Roques, JR, Darr, DB, Fleming, JM, Devi, GR, and Williams, KP. "Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells." Cancer Letters 411 (December 2017): 136-149.

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Arora, J, Sauer, SJ, Tarpley, M, Vermeulen, P, Rypens, C, Van Laere, S, Williams, KP, Devi, GR, and Dewhirst, MW. "Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies." Oncotarget 8, no. 16 (April 18, 2017): 25848-25863. (Academic Article)

Scholars@Duke

Shammas, RL, Fales, AM, Crawford, BM, Wisdom, AJ, Devi, GR, Brown, DA, Vo-Dinh, T, and Hollenbeck, ST. "Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation." Plastic and Reconstructive Surgery 139, no. 4 (April 2017): 900e-910e.

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Arora, J, Sauer, SJ, Tarpley, M, Vermeulen, P, Rypens, C, Van Laere, S, Williams, KP, Devi, GR, and Dewhirst, MW. "Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies." Oncotarget 8, no. 16 (April 2017): 25848-25863.

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Sauer, SJ, Tarpley, M, Shah, I, Save, AV, Lyerly, HK, Patierno, SR, Williams, KP, and Devi, GR. "Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells." Carcinogenesis 38, no. 3 (March 2017): 252-260.

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