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Gayathri R. Devi, PhD

Associate Director, Research Education
Associate Professor in Surgery
Associate Professor in Pathology
Office: 477 Med.sci.res.bldg. (msrb1), 2606 DUMC, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Dr. Devi’s research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer.

The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models.

Education and Training

  • Ph.D., University of Nebraska College of Medicine, 1998

Publications

Evans, MK, Brown, MC, Geradts, J, Bao, X, Robinson, TJ, Jolly, MK, Vermeulen, P, Palmer, GM, Gromeier, M, Levine, H, Morse, MA, Van Laere, S, and Devi, GR. "XIAP regulation by MNK links MAPK and NFκB signaling to determine an aggressive breast cancer phenotype." Cancer research (January 19, 2018).

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Oladapo, HO, Tarpley, M, Sauer, SJ, Addo, KA, Ingram, SM, Strepay, D, Ehe, BK, Chdid, L, Trinkler, M, Roques, JR, Darr, DB, Fleming, JM, Devi, GR, and Williams, KP. "Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells." Cancer letters 411 (December 2017): 136-149.

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Samy, KP, Davis, RP, Gao, Q, Martin, BM, Song, M, Cano, J, Farris, AB, McDonald, A, Gall, EK, Dove, CR, Leopardi, FV, How, T, Williams, KD, Devi, GR, Collins, BH, and Kirk, AD. "Early barriers to neonatal porcine islet engraftment in a dual transplant model." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (November 25, 2017).

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Arora, J, Sauer, SJ, Tarpley, M, Vermeulen, P, Rypens, C, Van Laere, S, Williams, KP, Devi, GR, and Dewhirst, MW. "Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies." ONCOTARGET 8, no. 16 (April 18, 2017): 25848-25863.

Scholars@Duke

Shammas, RL, Fales, AM, Crawford, BM, Wisdom, AJ, Devi, GR, Brown, DA, Vo-Dinh, T, and Hollenbeck, ST. "Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation." Plastic and reconstructive surgery 139, no. 4 (April 2017): 900e-910e.

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Arora, J, Sauer, SJ, Tarpley, M, Vermeulen, P, Rypens, C, Van Laere, S, Williams, KP, Devi, GR, and Dewhirst, MW. "Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies." Oncotarget 8, no. 16 (April 2017): 25848-25863.

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Sauer, SJ, Tarpley, M, Shah, I, Save, AV, Lyerly, HK, Patierno, SR, Williams, KP, and Devi, GR. "Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells." Carcinogenesis 38, no. 3 (March 2017): 252-260.

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Shammas, R, Fales, A, Crawford, B, Hollenbeck, S, Vo-Dinh, T, and Devi, G. "Abstract P3-16-02: Nanotheranostics using plasmonic gold nanostars to target inflammatory breast cancer cells and tumor emboli." February 15, 2017.

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Crawford, BM, Shammas, RL, Fales, AM, Brown, DA, Hollenbeck, ST, Vo-Dinh, T, and Devi, GR. "Photothermal ablation of inflammatory breast cancer tumor emboli using plasmonic gold nanostars." International Journal of Nanomedicine 12 (January 2017): 6259-6272.

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Woodward, WA, Cristofanilli, M, Merajver, SD, Van Laere, S, Pusztai, L, Bertucci, F, Berditchevski, F, Polyak, K, Overmoyer, B, Devi, GR, Sterneck, E, Schneider, R, Debeb, BG, Wang, X, van Golen, KL, El-Zein, R, Rahal, OM, Alexander, A, Reuben, JM, Krishnamurthy, S, Lucci, A, and Ueno, NT. "Scientific Summary from the Morgan Welch MD Anderson Cancer Center Inflammatory Breast Cancer (IBC) Program 10 th Anniversary Conference." Journal of Cancer 8, no. 17 (2017): 3607-3614.

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