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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Gulack, Brian C., Chi-Fu Jeffrey Yang, Paul J. Speicher, Babatunde A. Yerokun, Betty C. Tong, Mark W. Onaitis, Thomas A. D’Amico, David H. Harpole, Matthew G. Hartwig, and Mark F. Berry. “A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer.” Ann Thorac Surg 102, no. 6 (December 2016): 1814–20. https://doi.org/10.1016/j.athoracsur.2016.06.032.

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Yang, Chi-Fu Jeffrey, Brandon W. Yan, Robert Ryan Meyerhoff, Shakir M. Saud, Brian C. Gulack, Paul J. Speicher, Matthew G. Hartwig, Thomas A. D’Amico, David H. Harpole, and Mark F. Berry. “Impact of Age on Long-Term Outcomes of Surgery for Malignant Pleural Mesothelioma.” Clin Lung Cancer 17, no. 5 (September 2016): 419–26. https://doi.org/10.1016/j.cllc.2016.03.002.

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Speicher, Paul J., Zachary W. Fitch, Brian C. Gulack, Chi-Fu J. Yang, Betty C. Tong, David H. Harpole, Thomas A. D’Amico, Mark F. Berry, and Matthew G. Hartwig. “Induction Chemotherapy is Not Superior to a Surgery-First Strategy for Clinical N1 Non-Small Cell Lung Cancer.” Ann Thorac Surg 102, no. 3 (September 2016): 884–94. https://doi.org/10.1016/j.athoracsur.2016.05.065.

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Yang, Chi-Fu Jeffrey, Nicholas R. Mayne, Hanghang Wang, Ryan R. Meyerhoff, Sameer Hirji, Betty C. Tong, Matthew Hartwig, David Harpole, Thomas A. D’Amico, and Mark Berry. “Outcomes of Major Lung Resection After Induction Therapy for Non-Small Cell Lung Cancer in Elderly Patients.” Ann Thorac Surg 102, no. 3 (September 2016): 962–70. https://doi.org/10.1016/j.athoracsur.2016.03.088.

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Yerokun, Babatunde A., Zhifei Sun, Chi-Fu Jeffrey Yang, Brian C. Gulack, Paul J. Speicher, Mohamed A. Adam, Thomas A. D’Amico, et al. “Minimally Invasive Versus Open Esophagectomy for Esophageal Cancer: A Population-Based Analysis.” Ann Thorac Surg 102, no. 2 (August 2016): 416–23. https://doi.org/10.1016/j.athoracsur.2016.02.078.

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Yang, Chi-Fu Jeffrey, Syed M. Adil, Kevin L. Anderson, Robert Ryan Meyerhoff, Ryan S. Turley, Matthew G. Hartwig, David H. Harpole, et al. “Impact of patient selection and treatment strategies on outcomes after lobectomy for biopsy-proven stage IIIA pN2 non-small cell lung cancer.” Eur J Cardiothorac Surg 49, no. 6 (June 2016): 1607–13. https://doi.org/10.1093/ejcts/ezv431.

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Yang, Chi-Fu Jeffrey, Robert Ryan Meyerhoff, Nicholas Ryan Mayne, Terry Singhapricha, Christopher B. Toomey, Paul J. Speicher, Matthew G. Hartwig, et al. “Long-term survival following open versus thoracoscopic lobectomy after preoperative chemotherapy for non-small cell lung cancer.” Eur J Cardiothorac Surg 49, no. 6 (June 2016): 1615–23. https://doi.org/10.1093/ejcts/ezv428.

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Yang, Chi-Fu Jeffrey, Derek Y. Chan, Paul J. Speicher, Brian C. Gulack, Xiaofei Wang, Matthew G. Hartwig, Mark W. Onaitis, et al. “Role of Adjuvant Therapy in a Population-Based Cohort of Patients With Early-Stage Small-Cell Lung Cancer.” J Clin Oncol 34, no. 10 (April 1, 2016): 1057–64. https://doi.org/10.1200/JCO.2015.63.8171.

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Yang, Chi-Fu Jeffrey, Zhifei Sun, Paul J. Speicher, Shakir M. Saud, Brian C. Gulack, Matthew G. Hartwig, David H. Harpole, et al. “Use and Outcomes of Minimally Invasive Lobectomy for Stage I Non-Small Cell Lung Cancer in the National Cancer Data Base.” Ann Thorac Surg 101, no. 3 (March 2016): 1037–42. https://doi.org/10.1016/j.athoracsur.2015.11.018.

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