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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Yerokun, Babatunde A., Chi-Fu Jeffrey Yang, Brian C. Gulack, Xuechan Li, Michael S. Mulvihill, Lin Gu, Xiaofei Wang, et al. “A national analysis of wedge resection versus stereotactic body radiation therapy for stage IA non-small cell lung cancer.” J Thorac Cardiovasc Surg 154, no. 2 (August 2017): 675-686.e4. https://doi.org/10.1016/j.jtcvs.2017.02.065.

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Yao, Xiaoxin I., Xiaofei Wang, Paul J. Speicher, E Shelley Hwang, Perry Cheng, David H. Harpole, Mark F. Berry, Deborah Schrag, and Herbert H. Pang. “Reporting and Guidelines in Propensity Score Analysis: A Systematic Review of Cancer and Cancer Surgical Studies.” J Natl Cancer Inst 109, no. 8 (August 1, 2017). https://doi.org/10.1093/jnci/djw323.

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Yang, Chi-Fu Jeffrey, Derek Y. Chan, Paul J. Speicher, Brian C. Gulack, Betty C. Tong, Matthew G. Hartwig, Christopher R. Kelsey, Thomas A. D’Amico, Mark F. Berry, and David H. Harpole. “Surgery Versus Optimal Medical Management for N1 Small Cell Lung Cancer.” Ann Thorac Surg 103, no. 6 (June 2017): 1767–72. https://doi.org/10.1016/j.athoracsur.2017.01.043.

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Borer, Elizabeth T., James B. Grace, W Stanley Harpole, Andrew S. MacDougall, and Eric W. Seabloom. “A decade of insights into grassland ecosystem responses to global environmental change.” Nat Ecol Evol 1, no. 5 (April 20, 2017): 118. https://doi.org/10.1038/s41559-017-0118.

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Cox, Morgan L., Chi-Fu Jeffrey Yang, Paul J. Speicher, Kevin L. Anderson, Zachary W. Fitch, Lin Gu, Robert Patrick Davis, et al. “The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients.” J Thorac Oncol 12, no. 4 (April 2017): 689–96. https://doi.org/10.1016/j.jtho.2017.01.003.

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Giattino, Charles M., Jacob E. Gardner, Faris M. Sbahi, Kenneth C. Roberts, Mary Cooter, Eugene Moretti, Jeffrey N. Browndyke, et al. “Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.” Front Syst Neurosci 11 (2017): 24. https://doi.org/10.3389/fnsys.2017.00024.

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Torok, Jordan A., Lin Gu, Daniel J. Tandberg, Xiaofei Wang, David H. Harpole, Chris R. Kelsey, and Joseph K. Salama. “Patterns of Distant Metastases After Surgical Management of Non-Small-cell Lung Cancer.” Clin Lung Cancer 18, no. 1 (January 2017): e57–70. https://doi.org/10.1016/j.cllc.2016.06.011.

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