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David Charles Montefiori, PhD

Professor of Surgery
Office: Surgical Oncology Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

Dr. Montefiori is Professor and Director of the Laboratory for AIDS Vaccine Research and Development in the Department of Surgery, Division of Surgical Sciences, Duke University Medical Center. His major research interests are viral immunology and AIDS vaccine development, with a special emphasis on neutralizing antibodies. One of his highest priorities is to identify immunogens that generate broadly cross-reactive neutralizing antibodies for inclusion in HIV vaccines.  Many aspects of the neutralizing antibody response are studied in his laboratory, including mechanisms of neutralization and escape, epitope diversity among genetic subtypes and geographic origins, ontogeny of broadly neutralizing antibody responses and computationally-assisted vaccine design. Over the years he has explored multiple types of assays for neutralizing antibodies and other potential antiviral antibodies, focusing on assay optimization, standardization, validation and high throughput. The scope of research covers HIV-infected individuals and nonhuman primate models of simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) infection.  Dr. Montefiori also directs a large AIDS vaccine immune monitoring program, which operates in compliance with Good Clinical Laboratory Practice and has served as a national and international resource for standardized assessments of neutralizing antibody responses in preclinical and clinical trials of candidate AIDS vaccines since 1988. In 2002 he chaired the Antibody Laboratory Standardization Working Group that assisted in the design of the Global HIV Vaccine Enterprise Strategic Plan for HIV vaccines. He currently directs the Core Neutralizing Antibody Laboratories for the HIV Vaccine Clinical Trials Network (HVTN), the NIH Preclinical HIV-1 Vaccine Program and the Center for HIV/AIDS Vaccine Immunology- Immunogen Design (CHAVI-ID). He also directs a large Comprehensive Antibody Vaccine Immune Monitoring Consortium (CAVIMC) as part of the Bill and Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery (CAVD). He has published over 500 original research papers that have helped shape the scientific rationale for antibody-based HIV-1 vaccines.

Education and Training

  • Ph.D., Clemson University, 1982

Publications

Montefiori, DC, Roederer, M, Morris, L, and Seaman, MS. "Neutralization tiers of HIV-1. (Accepted)" Current opinion in HIV and AIDS 13, no. 2 (March 2018): 128-136.

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de Taeye, SW, de la Peña, AT, Vecchione, A, Scutigliani, E, Sliepen, K, Burger, JA, van der Woude, P, Schorcht, A, Schermer, EE, van Gils, MJ, LaBranche, CC, Montefiori, DC, Wilson, IA, Moore, JP, Ward, AB, and Sanders, RW. "Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers." The Journal of biological chemistry 293, no. 5 (February 2018): 1688-1701.

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Yates, NL, deCamp, AC, Korber, BT, Liao, H-X, Irene, C, Pinter, A, Peacock, J, Harris, LJ, Sawant, S, Hraber, P, Shen, X, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Berman, PW, Robb, ML, Pantaleo, G, Zolla-Pazner, S, Haynes, BF, Alam, SM, Montefiori, DC, and Tomaras, GD. "HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees." Journal of virology (January 31, 2018).

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Torrents de la Peña, A, de Taeye, SW, Sliepen, K, LaBranche, CC, Burger, JA, Schermer, EE, Montefiori, DC, Moore, JP, Klasse, PJ, and Sanders, RW. "Immunogenicity in rabbits of SOSIP trimers from clades A, B and C, given individually, sequentially or in combinations." Journal of virology (January 24, 2018).

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Wills, S, Hwang, K-K, Liu, P, Dennison, SM, Zirui Tay, M, Shen, X, Pollara, J, Lucas, JT, Parks, R, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Thomas, R, Kim, JH, Michael, NL, Robb, ML, McRaven, M, Montefiori, DC, Hope, TJ, Liao, H-X, Moody, MA, Ferrari, G, Haynes, BF, Alam, SM, Bonsignori, M, and Tomaras, GD. "HIV-1 specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galcer Blocking and Phagocytosis." Journal of virology (January 10, 2018).

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Schultz, A, Germann, A, Fuss, M, Sarzotti-Kelsoe, M, Ozaki, DA, Montefiori, DC, Zimmermann, H, and von Briesen, H. "Validation of an automated system for aliquoting of HIV-1 Env-pseudotyped virus stocks." PloS one 13, no. 1 (January 4, 2018): e0190669-.

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Malherbe, DC, Mendy, J, Vang, L, Barnette, PT, Reed, J, Lakhashe, SK, Owuor, J, Gach, JS, Legasse, AW, Axthelm, MK, LaBranche, CC, Montefiori, D, Forthal, DN, Park, B, Wilson, JM, McLinden, JH, Xiang, J, Stapleton, JT, Sacha, JB, Haynes, BF, Liao, H-X, Ruprecht, RM, Smith, J, Gurwith, M, Haigwood, NL, and Alexander, J. "Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge." Journal of virology 92, no. 2 (January 2018).

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Hraber, P, Rademeyer, C, Williamson, C, Seaman, MS, Gottardo, R, Tang, H, Greene, K, Gao, H, LaBranche, C, Mascola, JR, Morris, L, Montefiori, DC, and Korber, B. "Correction for Hraber et al., "Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments"." Journal of virology 92, no. 1 (January 2018).

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Hogan, MJ, Conde-Motter, A, Jordan, APO, Yang, L, Cleveland, B, Guo, W, Romano, J, Ni, H, Pardi, N, LaBranche, CC, Montefiori, DC, Hu, S-L, Hoxie, JA, and Weissman, D. "Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization." Virology 514 (January 2018): 106-117.

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Jones, AT, Chamcha, V, Kesavardhana, S, Shen, X, Beaumont, D, Das, R, Wyatt, LS, LaBranche, CC, Stanfield-Oakley, S, Ferrari, G, Montefiori, DC, Moss, B, Tomaras, GD, Varadarajan, R, and Amara, RR. "A trimeric HIV-1 envelope gp120 immunogen induces potent and broad anti-V1V2 loop antibodies against HIV-1 in rabbits and rhesus macaques." Journal of Virology (December 13, 2017).

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