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David Charles Montefiori, PhD

Professor of Surgery
Office: Surgical Oncology Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

Dr. Montefiori is Professor and Director of the Laboratory for AIDS Vaccine Research and Development in the Department of Surgery, Division of Surgical Sciences, Duke University Medical Center. His major research interests are viral immunology and AIDS vaccine development, with a special emphasis on neutralizing antibodies. One of his highest priorities is to identify immunogens that generate broadly cross-reactive neutralizing antibodies for inclusion in HIV vaccines.  Many aspects of the neutralizing antibody response are studied in his laboratory, including mechanisms of neutralization and escape, epitope diversity among genetic subtypes and geographic origins, ontogeny of broadly neutralizing antibody responses and computationally-assisted vaccine design. Over the years he has explored multiple types of assays for neutralizing antibodies and other potential antiviral antibodies, focusing on assay optimization, standardization, validation and high throughput. The scope of research covers HIV-infected individuals and nonhuman primate models of simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) infection.  Dr. Montefiori also directs a large AIDS vaccine immune monitoring program, which operates in compliance with Good Clinical Laboratory Practice and has served as a national and international resource for standardized assessments of neutralizing antibody responses in preclinical and clinical trials of candidate AIDS vaccines since 1988. In 2002 he chaired the Antibody Laboratory Standardization Working Group that assisted in the design of the Global HIV Vaccine Enterprise Strategic Plan for HIV vaccines. He currently directs the Core Neutralizing Antibody Laboratories for the HIV Vaccine Clinical Trials Network (HVTN), the NIH Preclinical HIV-1 Vaccine Program and the Center for HIV/AIDS Vaccine Immunology- Immunogen Design (CHAVI-ID). He also directs a large Comprehensive Antibody Vaccine Immune Monitoring Consortium (CAVIMC) as part of the Bill and Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery (CAVD). He has published over 500 original research papers that have helped shape the scientific rationale for antibody-based HIV-1 vaccines.

Education and Training

  • Ph.D., Clemson University, 1982

Publications

Yates, NL, deCamp, AC, Korber, BT, Liao, H-X, Irene, C, Pinter, A, Peacock, J, Harris, LJ, Sawant, S, Hraber, P, Shen, X, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Berman, PW, Robb, ML, Pantaleo, G, Zolla-Pazner, S, Haynes, BF, Alam, SM, Montefiori, DC, and Tomaras, GD. "HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees." Journal of virology 92, no. 8 (April 2018).

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Wills, S, Hwang, K-K, Liu, P, Dennison, SM, Tay, MZ, Shen, X, Pollara, J, Lucas, JT, Parks, R, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Thomas, R, Kim, JH, Michael, NL, Robb, ML, McRaven, M, Montefiori, DC, Hope, TJ, Liao, H-X, Moody, MA, Ferrari, G, Haynes, BF, Alam, SM, Bonsignori, M, and Tomaras, GD. "HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis." Journal of virology 92, no. 7 (April 2018).

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Torrents de la Peña, A, de Taeye, SW, Sliepen, K, LaBranche, CC, Burger, JA, Schermer, EE, Montefiori, DC, Moore, JP, Klasse, PJ, and Sanders, RW. "Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination." Journal of virology 92, no. 8 (April 2018).

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Saunders, KO, Santra, S, Parks, R, Yates, NL, Sutherland, LL, Scearce, RM, Balachandran, H, Bradley, T, Goodman, D, Eaton, A, Stanfield-Oakley, SA, Tartaglia, J, Phogat, S, Pantaleo, G, Esteban, M, Gomez, CE, Perdiguero, B, Jacobs, B, Kibler, K, Korber, B, Montefiori, DC, Ferrari, G, Vandergrift, N, Liao, H-X, Tomaras, GD, and Haynes, BF. "Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates." Journal of virology 92, no. 8 (April 2018).

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Wagh, K, Seaman, MS, Zingg, M, Fitzsimons, T, Barouch, DH, Burton, DR, Connors, M, Ho, DD, Mascola, JR, Nussenzweig, MC, Ravetch, J, Gautam, R, Martin, MA, Montefiori, DC, and Korber, B. "Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections." PLoS pathogens 14, no. 3 (March 5, 2018): e1006860-.

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Jones, AT, Chamcha, V, Kesavardhana, S, Shen, X, Beaumont, D, Das, R, Wyatt, LS, LaBranche, CC, Stanfield-Oakley, S, Ferrari, G, Montefiori, DC, Moss, B, Tomaras, GD, Varadarajan, R, and Amara, RR. "A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques." Journal of virology 92, no. 5 (March 2018).

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Montefiori, DC, Roederer, M, Morris, L, and Seaman, MS. "Neutralization tiers of HIV-1." Current opinion in HIV and AIDS 13, no. 2 (March 2018): 128-136.

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Cohen, YZ, Lorenzi, JCC, Seaman, MS, Nogueira, L, Schoofs, T, Krassnig, L, Butler, A, Millard, K, Fitzsimons, T, Daniell, X, Dizon, JP, Shimeliovich, I, Montefiori, DC, Caskey, M, and Nussenzweig, MC. "Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells." Journal of virology 92, no. 5 (March 2018).

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Klasse, PJ, Ketas, TJ, Cottrell, CA, Ozorowski, G, Debnath, G, Camara, D, Francomano, E, Pugach, P, Ringe, RP, LaBranche, CC, van Gils, MJ, Bricault, CA, Barouch, DH, Crotty, S, Silvestri, G, Kasturi, S, Pulendran, B, Wilson, IA, Montefiori, DC, Sanders, RW, Ward, AB, and Moore, JP. "Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques." PLoS pathogens 14, no. 2 (February 23, 2018): e1006913-.

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de Taeye, SW, de la Peña, AT, Vecchione, A, Scutigliani, E, Sliepen, K, Burger, JA, van der Woude, P, Schorcht, A, Schermer, EE, van Gils, MJ, LaBranche, CC, Montefiori, DC, Wilson, IA, Moore, JP, Ward, AB, and Sanders, RW. "Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers." The Journal of biological chemistry 293, no. 5 (February 2018): 1688-1701.

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