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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Prichard, Heather L., Thies Schroeder, William M. Reichert, and Bruce Klitzman. “Bioluminescence imaging of glucose in tissue surrounding polyurethane and glucose sensor implants.” J Diabetes Sci Technol 4, no. 5 (September 1, 2010): 1055–62. https://doi.org/10.1177/193229681000400504.

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Yang, Jun, Detlev Erdmann, J. C. Chang, Issei Komatsu, YiXin Zhang, DanRu Wang, Michael S. Hodavance, et al. “A model of sequential heart and composite tissue allotransplant in rats.” Plast Reconstr Surg 126, no. 1 (July 2010): 80–86. https://doi.org/10.1097/PRS.0b013e3181dbbb64.

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Koschwanez, H. E., W. M. Reichert, and B. Klitzman. “Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance.” J Biomed Mater Res A 93, no. 4 (June 15, 2010): 1348–57. https://doi.org/10.1002/jbm.a.32630.

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Huang, Xin, Stefan Zauscher, Bruce Klitzman, George A. Truskey, William M. Reichert, Daniel J. Kenan, and Mark W. Grinstaff. “Peptide interfacial biomaterials improve endothelial cell adhesion and spreading on synthetic polyglycolic acid materials.” Ann Biomed Eng 38, no. 6 (June 2010): 1965–76. https://doi.org/10.1007/s10439-010-9986-5.

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Schroeder, Thies, Natalie Wisniewski, Alina Boico, Nga Le, Eugenia Cho, Kristen Helton, Rebecca Gant, and Bruce Klitzman. “Long-term tissue integration of porous biopolymers as a material platform for metabolic biosensor.” In Faseb Journal, Vol. 24, 2010.

Scholars@Duke

Talaat, W. M., T. A. McGraw, and B. Klitzman. “Relationship between the canthal-tragus distance and the puncture point in temporomandibular joint arthroscopy.” Int J Oral Maxillofac Surg 39, no. 1 (January 2010): 57–60. https://doi.org/10.1016/j.ijom.2009.11.016.

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DeCroos, Francis Char, Sameer Ahmad, Yuji Kondo, Jessica Chow, Daniel Mordes, Maria Regina Lee, Sanjay Asrani, R Rand Allingham, Kevin C. Olbrich, and Bruce Klitzman. “Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve.” Curr Eye Res 34, no. 7 (July 2009): 562–67. https://doi.org/10.1080/02713680902963167.

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Pradka, S. P., Y. S. Ong, Y. Zhang, S. J. Davis, A. Baccarani, C. Messmer, T. A. Fields, D. Erdmann, B. Klitzman, and L. S. Levin. “Increased signs of acute rejection with ischemic time in a rat musculocutaneous allotransplant model.” Transplant Proc 41, no. 2 (March 2009): 531–36. https://doi.org/10.1016/j.transproceed.2009.01.021.

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Prichard, H. L., W. M. Reichert, and B. Klitzman. “Adipose stem cell attachment to glucose sensors.” In 8th World Biomaterials Congress 2008, 4:2099, 2008.

Scholars@Duke

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