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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

FLEMING, B. P., B. KLITZMAN, and W. O. JOHNSON. “A PERIODIC DIFFERENTIAL DETECTOR FOR MICROVASCULAR VELOCIMETRY.” International Journal of Microcirculation Clinical and Experimental. KARGER, January 1, 1984.

Scholars@Duke

FLEMING, B. P., B. KLITZMAN, and W. O. JOHNSON. “A PERIODIC DIFFERENTIAL DETECTOR FOR MICROVASCULAR VELOCIMETRY.” Microvascular Research. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, January 1, 1984.

Scholars@Duke

KLITZMAN, B. “RELATIVE VELOCITY OF RED-CELLS AND SUB-MICRON PARTICLES IN MUSCLE CAPILLARIES.” International Journal of Microcirculation Clinical and Experimental. KARGER, January 1, 1984.

Scholars@Duke

KLITZMAN, B. “EFFECT OF FLUORESCENT LABELING OF RED-CELLS ON FLOW THROUGH CAPILLARIES.” Microvascular Research. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, January 1, 1983.

Scholars@Duke

Klitzman, B., A. S. Popel, and B. R. Duling. “Oxygen transport in resting and contracting hamster cremaster muscles: experimental and theoretical microvascular studies.” Microvasc Res 25, no. 1 (January 1983): 108–31. https://doi.org/10.1016/0026-2862(83)90047-x.

Full Text

Klitzman, B., D. N. Damon, R. J. Gorczynski, and B. R. Duling. “Augmented tissue oxygen supply during striated muscle contraction in the hamster. Relative contributions of capillary recruitment, functional dilation, and reduced tissue PO2.” Circ Res 51, no. 6 (December 1982): 711–21. https://doi.org/10.1161/01.res.51.6.711.

Full Text

KLITZMAN, B., J. MYERS, R. P. WATTS, and P. C. JOHNSON. “MEASUREMENT OF MICRO-VASCULAR HEMATOCRIT AND RED-CELL VELOCITY USING STROBOSCOPIC EPI-FLUORESCENCE MICROSCOPY.” In Federation Proceedings, 41:1759–1759. FEDERATION AMER SOC EXP BIOL, 1982.

Scholars@Duke

KLITZMAN, B., and P. C. JOHNSON. “FACTORS AFFECTING THE DISTRIBUTION OF RED-BLOOD-CELLS AT CAPILLARY BIFURCATIONS.” Microvascular Research. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, January 1, 1981.

Scholars@Duke

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