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Bruce Klitzman, PhD

Associate Professor in Surgery
Assistant Research Professor in Cell Biology
Associate Research Professor of Biomedical Engineering
Office: 0112 Baker House, Trent Dr, Durham, NC 27710
Campus Mail: DUMC Plastic Surgery, Duke University Medical Center, Durham, NC 27710

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education and Training

  • Ph.D., University of Virginia, 1979

In the News

Publications

Ibrahim, Mohamed M., Jennifer S. Chien, Mahmoud M. Mohammed, Timothy King, and Bruce Klitzman. “RAPID DETECTION OF ACUTE VASCULAR OCCLUSION USING OXYGEN MONITORING IN A RAT MYOCUTANEOUS FLAP MODEL.” In Wound Repair and Regeneration, 25:A40–A40. WILEY, 2017.

Scholars@Duke

Schweller, Ryan M., Zi Jun Wu, Bruce Klitzman, and Jennifer L. West. “Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo.” Ann Biomed Eng 45, no. 6 (June 2017): 1387–98. https://doi.org/10.1007/s10439-017-1822-8.

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Chien, J., M. Mohammed, H. Eldik, M. Ibrahim, S. Nichols, and B. Klitzman. “Implantable Oxygen Biosensors Reveals Post-occlusion Tissue Reactive Hyperoxia.” In Journal of Vascular Research, 54:37–38. KARGER, 2017.

Scholars@Duke

Kasili, P. M., and T. Vo-Dinh. “Monitoring apoptosis and anticancer drug activity in single cells using nanosensors.” In Nanotechnology in Biology and Medicine: Methods, Devices, and Applications, Second Edition, 423–38, 2017. https://doi.org/10.4324/9781315374581.

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Wisniewski, Natalie A., Scott P. Nichols, Soya J. Gamsey, Steve Pullins, Kit Y. Au-Yeung, Bruce Klitzman, and Kristen L. Helton. “Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.” Adv Exp Med Biol 977 (2017): 377–83. https://doi.org/10.1007/978-3-319-55231-6_49.

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Shammas, Ronnie L., Andrew M. Fales, Bridget M. Crawford, Bruce Klitzman, Scott T. Hollenbeck, and Tuan VoDinh. “Plasmonic Gold-Nanostars for Tracking of Adult Stem Cells and for Selective Photothermal Ablation.” In Journal of the American College of Surgeons, 223:S100–S100. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.1016/j.jamcollsurg.2016.06.204.

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Eldik, H., B. Klitzman, M. Ibrahim, J. Martinez, S. Nichols, and N. Wisniewksi. “548 Real-time continuous monitoring of subcutaneous tissue oxygenation.” In Journal of Investigative Dermatology, 136:S254–S254. Elsevier BV, 2016. https://doi.org/10.1016/j.jid.2016.06.572.

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Eldik, H., M. Mohamed, J. Martinez, N. Wisiniewski, S. Nichols, and B. Klitzman. “LB823 Real-time continuous monitoring of tissue oxygenation: Quantifying critically ischemic flap regions.” In Journal of Investigative Dermatology, 136:B13–B13. Elsevier BV, 2016. https://doi.org/10.1016/j.jid.2016.05.082.

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Ibrahim, Mohamed, Vrad Levering, Eileen Lanham, James Parra, Harold Leraas, Gabriel Lopez, Bruce Klitzman, Andrew Peterson, and Howard Levinson. “MP24-17 PERVASIVE BIOFILM COVERAGE: AN ANALYSIS OF BIOFILM FORMATION IN INDWELLING URINARY CATHETERS.” In Journal of Urology, Vol. 195. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.1016/j.juro.2016.02.773.

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Ibrahim, M. M., M. A. Medina, J. Bond, L. Chen, C. Quiles, G. Kokosis, L. Bashirov, A. Selim, B. Klitzman, and H. Levinson. “FOREIGN BODY REACTION TO COMMONLY USED SURGICAL BIOMATERIALS.” Wound Repair and Regeneration 24, no. 2 (March 1, 2016): A12–13.

Scholars@Duke

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